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Items: 1 to 20 of 43

1.

Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.

Cheng Z, Valença WO, Dias GG, Scott J, Barth ND, de Moliner F, Souza GBP, Mellanby RJ, Vendrell M, da Silva Júnior EN.

Bioorg Med Chem. 2019 Jul 15. pii: S0968-0896(19)30827-2. doi: 10.1016/j.bmc.2019.07.017. [Epub ahead of print]

PMID:
31327676
2.

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones.

da Silva Júnior EN, Jardim GAM, Jacob C, Dhawa U, Ackermann L, de Castro SL.

Eur J Med Chem. 2019 Jun 25;179:863-915. doi: 10.1016/j.ejmech.2019.06.056. [Epub ahead of print] Review.

PMID:
31306817
3.

Dynamics of aggregated states resolved by gated fluorescence in films of room temperature phosphorescent emitters.

Dos Santos PL, Silveira OJ, Huang R, Jardim GAM, Matos MJS, da Silva Júnior EN, Monkman AP, Dias FB, Cury LA.

Phys Chem Chem Phys. 2019 Feb 13;21(7):3814-3821. doi: 10.1039/c8cp07005a.

PMID:
30698176
4.

Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles.

Bombaça ACS, Viana PG, Santos ACC, Silva TL, Rodrigues ABM, Guimarães ACR, Goulart MOF, da Silva Júnior EN, Menna-Barreto RFS.

Free Radic Biol Med. 2019 Jan;130:408-418. doi: 10.1016/j.freeradbiomed.2018.11.012. Epub 2018 Nov 14.

PMID:
30445126
5.

Ruthenium-catalyzed C-H oxygenation of quinones by weak O-coordination for potent trypanocidal agents.

Dias GG, Rogge T, Kuniyil R, Jacob C, Menna-Barreto RFS, da Silva Júnior EN, Ackermann L.

Chem Commun (Camb). 2018 Nov 13;54(91):12840-12843. doi: 10.1039/c8cc07572g.

PMID:
30374498
6.

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor.

Rodrigues T, Werner M, Roth J, da Cruz EHG, Marques MC, Akkapeddi P, Lobo SA, Koeberle A, Corzana F, da Silva Júnior EN, Werz O, Bernardes GJL.

Chem Sci. 2018 Jul 17;9(34):6899-6903. doi: 10.1039/c8sc02634c. eCollection 2018 Sep 14.

7.

Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets.

de Moliner F, King A, Dias GG, de Lima GF, de Simone CA, da Silva Júnior EN, Vendrell M.

Front Chem. 2018 Aug 13;6:339. doi: 10.3389/fchem.2018.00339. eCollection 2018.

8.

Encapsulation of nor-β-lapachone into poly(d,l)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines.

Costa MP, Feitosa ACS, Oliveira FCE, Cavalcanti BC, Dias GG, Caetano EWS, Sales FAM, Freire VN, Di Fiore S, Fischer R, Ladeira LO, da Silva Júnior EN, Pessoa C.

Medchemcomm. 2017 Sep 7;8(10):1993-2002. doi: 10.1039/c7md00196g. eCollection 2017 Oct 1.

9.

Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon-Nanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones.

de Carvalho RL, Jardim GAM, Santos ACC, Araujo MH, Oliveira WXC, Bombaça ACS, Menna-Barreto RFS, Gopi E, Gravel E, Doris E, da Silva Júnior EN.

Chemistry. 2018 Oct 12;24(57):15227-15235. doi: 10.1002/chem.201802773. Epub 2018 Sep 6.

PMID:
29904959
10.

Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C-H activation: the case of A-ring functionalization.

da Silva Júnior EN, Jardim GAM, Gomes RS, Liang YF, Ackermann L.

Chem Commun (Camb). 2018 Jul 3;54(54):7398-7411. doi: 10.1039/c8cc03147a.

PMID:
29863215
11.

Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells.

Baiju TV, Almeida RG, Sivanandan ST, de Simone CA, Brito LM, Cavalcanti BC, Pessoa C, Namboothiri INN, da Silva Júnior EN.

Eur J Med Chem. 2018 May 10;151:686-704. doi: 10.1016/j.ejmech.2018.03.079. Epub 2018 Apr 5.

PMID:
29660689
12.

A UBI 31-38 Peptide-coumarin Conjugate: Photophysical Features, Imaging Tracking and Synergism with Amphotericin B Against Cryptococcus.

Ferreira SMZMD, Carneiro HC, Alves RB, Batista ACS, da Silva Junior EN, Dias GG, Resende JM, Santos DA, Oliveira DL, Rodrigues ML, Freitas RP.

Curr Top Med Chem. 2018;18(2):157-163. doi: 10.2174/1568026618666180221113137.

PMID:
29473511
13.

Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones.

Jardim GAM, Oliveira WXC, de Freitas RP, Menna-Barreto RFS, Silva TL, Goulart MOF, da Silva Júnior EN.

Org Biomol Chem. 2018 Mar 7;16(10):1686-1691. doi: 10.1039/c8ob00196k.

PMID:
29450434
14.

Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions.

Jardim GAM, Lima DJB, Valença WO, Lima DJB, Cavalcanti BC, Pessoa C, Rafique J, Braga AL, Jacob C, da Silva Júnior EN, da Cruz EHG.

Molecules. 2017 Dec 30;23(1). pii: E83. doi: 10.3390/molecules23010083.

15.

Quinone-based fluorophores for imaging biological processes.

Dias GG, King A, de Moliner F, Vendrell M, da Silva Júnior EN.

Chem Soc Rev. 2018 Jan 2;47(1):12-27. doi: 10.1039/c7cs00553a. Review.

PMID:
29099127
16.

On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells.

Gontijo TB, de Freitas RP, Emery FS, Pedrosa LF, Vieira Neto JB, Cavalcanti BC, Pessoa C, King A, de Moliner F, Vendrell M, da Silva Júnior EN.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4446-4456. doi: 10.1016/j.bmcl.2017.08.007. Epub 2017 Aug 4.

PMID:
28818447
17.

Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones.

Jardim GAM, Silva TL, Goulart MOF, de Simone CA, Barbosa JMC, Salomão K, de Castro SL, Bower JF, da Silva Júnior EN.

Eur J Med Chem. 2017 Aug 18;136:406-419. doi: 10.1016/j.ejmech.2017.05.011. Epub 2017 May 4.

PMID:
28521262
18.

Indirect consequences of exciplex states on the phosphorescence lifetime of phenazine-based 1,2,3-triazole luminescent probes.

Costa BB, Jardim GA, Santos PL, Calado HD, Monkman AP, Dias FB, da Silva Júnior EN, Cury LA.

Phys Chem Chem Phys. 2017 Feb 1;19(5):3473-3479. doi: 10.1039/c6cp06134f.

PMID:
27824176
19.

Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone.

Gontijo TB, de Freitas RP, de Lima GF, de Rezende LC, Pedrosa LF, Silva TL, F Goulart MO, Cavalcanti BC, Pessoa C, Bruno MP, Corrêa JR, Emery FS, da Silva Júnior EN.

Chem Commun (Camb). 2016 Nov 3;52(90):13281-13284.

PMID:
27775736
20.

Rh-Catalyzed Reactions of 1,4-Benzoquinones with Electrophiles: C-H Iodination, Bromination, and Phenylselenation.

Jardim GA, Bower JF, da Silva Júnior EN.

Org Lett. 2016 Sep 16;18(18):4454-7. doi: 10.1021/acs.orglett.6b01586. Epub 2016 Sep 7.

PMID:
27599589

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