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Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment.

Busquets O, Ettcheto M, Cano A, R Manzine P, Sánchez-Lopez E, Espinosa-Jiménez T, Verdaguer E, Dario Castro-Torres R, Beas-Zarate C, X Sureda F, Olloquequi J, Auladell C, Folch J, Camins A.

Int J Mol Sci. 2019 Dec 30;21(1). pii: E255. doi: 10.3390/ijms21010255. Review.


Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice.

Ettcheto M, Cano A, Manzine PR, Busquets O, Verdaguer E, Castro-Torres RD, García ML, Beas-Zarate C, Olloquequi J, Auladell C, Folch J, Camins A.

Mol Neurobiol. 2019 Dec 14. doi: 10.1007/s12035-019-01849-6. [Epub ahead of print]


c-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments.

Busquets O, Ettcheto M, Eritja À, Espinosa-Jiménez T, Verdaguer E, Olloquequi J, Beas-Zarate C, Castro-Torres RD, Casadesús G, Auladell C, Bulló M, Folch J, Camins A.

J Mol Med (Berl). 2019 Dec;97(12):1723-1733. doi: 10.1007/s00109-019-01856-z. Epub 2019 Dec 3.


A metabolic perspective of late onset Alzheimer's disease.

Ettcheto M, Cano A, Busquets O, Manzine PR, Sánchez-López E, Castro-Torres RD, Beas-Zarate C, Verdaguer E, García ML, Olloquequi J, Auladell C, Folch J, Camins A.

Pharmacol Res. 2019 Jul;145:104255. doi: 10.1016/j.phrs.2019.104255. Epub 2019 May 7. Review.


Role of brain c-Jun N-terminal kinase 2 in the control of the insulin receptor and its relationship with cognitive performance in a high-fat diet pre-clinical model.

Busquets O, Eritja À, López BM, Ettcheto M, Manzine PR, Castro-Torres RD, Verdaguer E, Olloquequi J, Vázquez-Carrera M, Auladell C, Folch J, Camins A.

J Neurochem. 2019 Apr;149(2):255-268. doi: 10.1111/jnc.14682. Epub 2019 Mar 27.


JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy.

Castro-Torres RD, Landa J, Rabaza M, Busquets O, Olloquequi J, Ettcheto M, Beas-Zarate C, Folch J, Camins A, Auladell C, Verdaguer E.

Mol Neurobiol. 2019 Aug;56(8):5856-5865. doi: 10.1007/s12035-019-1476-7. Epub 2019 Jan 26.


Triple GLP-1/GIP/glucagon receptor agonists, a potential novel treatment strategy in Alzheimer's disease.

Camins A, Ettcheto M, Busquets O, Manzine PR, Castro-Torres RD, Beas-Zarate C, Verdaguer E, Sureda FX, Bulló M, Olloquequi J, Auladell C, Folch J.

Expert Opin Investig Drugs. 2019 Jan;28(1):93-97. doi: 10.1080/13543784.2019.1552677. Epub 2018 Dec 1. No abstract available.


The Ethyl Acetate Extract of Leaves of Ugni molinae Turcz. Improves Neuropathological Hallmarks of Alzheimer's Disease in Female APPswe/PS1dE9 Mice Fed with a High Fat Diet.

Jara-Moreno D, Castro-Torres RD, Ettcheto M, Auladell C, Kogan MJ, Folch J, Verdaguer E, Cano A, Busquets O, Delporte C, Camins A.

J Alzheimers Dis. 2018;66(3):1175-1191. doi: 10.3233/JAD-180174.


Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications.

Olloquequi J, Cornejo-Córdova E, Verdaguer E, Soriano FX, Binvignat O, Auladell C, Camins A.

J Psychopharmacol. 2018 Mar;32(3):265-275. doi: 10.1177/0269881118754680. Epub 2018 Feb 15. Review.


The Implication of the Brain Insulin Receptor in Late Onset Alzheimer's Disease Dementia.

Folch J, Ettcheto M, Busquets O, Sánchez-López E, Castro-Torres RD, Verdaguer E, Manzine PR, Poor SR, García ML, Olloquequi J, Beas-Zarate C, Auladell C, Camins A.

Pharmaceuticals (Basel). 2018 Jan 29;11(1). pii: E11. doi: 10.3390/ph11010011. Review.


Memantine for the Treatment of Dementia: A Review on its Current and Future Applications.

Folch J, Busquets O, Ettcheto M, Sánchez-López E, Castro-Torres RD, Verdaguer E, Garcia ML, Olloquequi J, Casadesús G, Beas-Zarate C, Pelegri C, Vilaplana J, Auladell C, Camins A.

J Alzheimers Dis. 2018;62(3):1223-1240. doi: 10.3233/JAD-170672. Review.


JNK1 inhibition by Licochalcone A leads to neuronal protection against excitotoxic insults derived of kainic acid.

Busquets O, Ettcheto M, Verdaguer E, Castro-Torres RD, Auladell C, Beas-Zarate C, Folch J, Camins A.

Neuropharmacology. 2018 Mar 15;131:440-452. doi: 10.1016/j.neuropharm.2017.10.030. Epub 2017 Oct 28.


Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms.

de Lemos L, Junyent F, Camins A, Castro-Torres RD, Folch J, Olloquequi J, Beas-Zarate C, Verdaguer E, Auladell C.

Mol Neurobiol. 2018 May;55(5):4437-4452. doi: 10.1007/s12035-017-0669-1. Epub 2017 Jun 29.


Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's disease.

Busquets O, Ettcheto M, Pallàs M, Beas-Zarate C, Verdaguer E, Auladell C, Folch J, Camins A.

Mech Ageing Dev. 2017 Mar;162:38-45. doi: 10.1016/j.mad.2016.11.002. Epub 2016 Nov 15.


Role of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration.

Auladell C, de Lemos L, Verdaguer E, Ettcheto M, Busquets O, Lazarowski A, Beas-Zarate C, Olloquequi J, Folch J, Camins A.

Front Biosci (Landmark Ed). 2017 Jan 1;22:795-814. Review.


Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer's Disease.

Petrov D, Luque M, Pedrós I, Ettcheto M, Abad S, Pallàs M, Verdaguer E, Auladell C, Folch J, Camins A.

Mol Neurobiol. 2016 Nov;53(9):6183-6193. doi: 10.1007/s12035-015-9522-6. Epub 2015 Nov 12.


Vulnerability of calbindin, calretinin and parvalbumin in a transgenic/knock-in APPswe/PS1dE9 mouse model of Alzheimer disease together with disruption of hippocampal neurogenesis.

Verdaguer E, Brox S, Petrov D, Olloquequi J, Romero R, de Lemos ML, Camins A, Auladell C.

Exp Gerontol. 2015 Sep;69:176-88. doi: 10.1016/j.exger.2015.06.013. Epub 2015 Jun 20.


Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus.

Ettcheto M, Junyent F, de Lemos L, Pallas M, Folch J, Beas-Zarate C, Verdaguer E, Gómez-Sintes R, Lucas JJ, Auladell C, Camins A.

Mol Neurobiol. 2015 Aug;52(1):120-9. doi: 10.1007/s12035-014-8836-0. Epub 2014 Aug 15.


Glutamate excitotoxicity activates the MAPK/ERK signaling pathway and induces the survival of rat hippocampal neurons in vivo.

Ortuño-Sahagún D, González RM, Verdaguer E, Huerta VC, Torres-Mendoza BM, Lemus L, Rivera-Cervantes MC, Camins A, Zárate CB.

J Mol Neurosci. 2014 Mar;52(3):366-77. doi: 10.1007/s12031-013-0157-7. Epub 2013 Nov 5.


PI3 k/akt inhibition induces apoptosis through p38 activation in neurons.

Vázquez de la Torre A, Junyent F, Folch J, Pelegrí C, Vilaplana J, Auladell C, Beas-Zarate C, Pallàs M, Verdaguer E, Camins A.

Pharmacol Res. 2013 Apr;70(1):116-25. doi: 10.1016/j.phrs.2013.01.007. Epub 2013 Feb 1.


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