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Items: 1 to 20 of 50

1.

A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival.

de Jong Y, Bennani F, van Oosterwijk JG, Alberti G, Baranski Z, Wijers-Koster P, Venneker S, Briaire-de Bruij IH, van de Akker BE, Baelde H, Cleton-Jansen AM, van de Water B, Danen EHJ, Bovée JVMG.

J Bone Oncol. 2019 Nov 17;19:100268. doi: 10.1016/j.jbo.2019.100268. eCollection 2019 Dec.

2.

Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.

Venneker S, Kruisselbrink AB, Briaire-de Bruijn IH, de Jong Y, van Wijnen AJ, Danen EHJ, Bovée JVMG.

Cancers (Basel). 2019 Dec 2;11(12). pii: E1918. doi: 10.3390/cancers11121918.

3.

3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis.

Booij TH, Price LS, Danen EHJ.

SLAS Discov. 2019 Jul;24(6):615-627. doi: 10.1177/2472555219830087. Epub 2019 Feb 28.

4.

Cytoskeletal Anisotropy Controls Geometry and Forces of Adherent Cells.

Pomp W, Schakenraad K, Balcıoğlu HE, van Hoorn H, Danen EHJ, Merks RMH, Schmidt T, Giomi L.

Phys Rev Lett. 2018 Oct 26;121(17):178101. doi: 10.1103/PhysRevLett.121.178101.

PMID:
30411958
5.

IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer.

Zhang Y, Wester L, He J, Geiger T, Moerkens M, Siddappa R, Helmijr JA, Timmermans MM, Look MP, van Deurzen CHM, Martens JWM, Pont C, de Graauw M, Danen EHJ, Berns EMJJ, Meerman JHN, Jansen MPHM, van de Water B.

Oncogene. 2018 Apr;37(14):1869-1884. doi: 10.1038/s41388-017-0027-9. Epub 2018 Jan 22.

PMID:
29353882
6.

A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer.

Coppola S, Carnevale I, Danen EHJ, Peters GJ, Schmidt T, Assaraf YG, Giovannetti E.

Drug Resist Updat. 2017 Mar;31:43-51. doi: 10.1016/j.drup.2017.07.001. Epub 2017 Jul 24. Review.

PMID:
28867243
7.

NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.

Peterse EFP, van den Akker BEWM, Niessen B, Oosting J, Suijker J, de Jong Y, Danen EHJ, Cleton-Jansen AM, Bovée JVMG.

Mol Cancer Res. 2017 Dec;15(12):1714-1721. doi: 10.1158/1541-7786.MCR-17-0293. Epub 2017 Aug 31.

8.

Deciphering Epithelial-Mesenchymal Transition Regulatory Networks in Cancer through Computational Approaches.

Burger GA, Danen EHJ, Beltman JB.

Front Oncol. 2017 Aug 3;7:162. doi: 10.3389/fonc.2017.00162. eCollection 2017. Review.

9.

Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype.

Hillger JM, le Roy B, Wang Z, Mulder-Krieger T, Boomsma DI, Slagboom PE, Danen EHJ, IJzerman AP, Heitman LH.

Biochem Pharmacol. 2017 Apr 15;130:60-70. doi: 10.1016/j.bcp.2017.01.014. Epub 2017 Jan 31.

10.

Cellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour.

Fokkelman M, Balcıoğlu HE, Klip JE, Yan K, Verbeek FJ, Danen EH, van de Water B.

Sci Rep. 2016 Aug 17;6:31707. doi: 10.1038/srep31707.

11.

No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone.

Peterse EF, Cleven AH, De Jong Y, Briaire-de Bruijn I, Fletcher JA, Danen EH, Cleton-Jansen AM, Bovée JV.

BMC Cancer. 2016 Jul 14;16:475. doi: 10.1186/s12885-016-2522-8.

12.

Tumor-induced remote ECM network orientation steers angiogenesis.

Balcioglu HE, van de Water B, Danen EH.

Sci Rep. 2016 Mar 2;6:22580. doi: 10.1038/srep22580.

13.

MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation.

Baranski Z, Booij TH, Kuijjer ML, de Jong Y, Cleton-Jansen AM, Price LS, van de Water B, Bovée JV, Hogendoorn PC, Danen EH.

Genes Cancer. 2015 Nov;6(11-12):503-12.

14.

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin.

Baranski Z, de Jong Y, Ilkova T, Peterse EF, Cleton-Jansen AM, van de Water B, Hogendoorn PC, Bovée JV, Danen EH.

Oncotarget. 2015 Nov 3;6(34):36113-25. doi: 10.18632/oncotarget.5333.

15.

A guide to mechanobiology: Where biology and physics meet.

Jansen KA, Donato DM, Balcioglu HE, Schmidt T, Danen EH, Koenderink GH.

Biochim Biophys Acta. 2015 Nov;1853(11 Pt B):3043-52. doi: 10.1016/j.bbamcr.2015.05.007. Epub 2015 May 18. Review.

16.

Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.

Baranski Z, Booij TH, Cleton-Jansen AM, Price LS, van de Water B, Bovée JV, Hogendoorn PC, Danen EH.

J Pathol. 2015 Jul;236(3):348-59. doi: 10.1002/path.4528. Epub 2015 Mar 30.

PMID:
25757065
17.

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.

Heslop JA, Hammond TG, Santeramo I, Tort Piella A, Hopp I, Zhou J, Baty R, Graziano EI, Proto Marco B, Caron A, Sköld P, Andrews PW, Baxter MA, Hay DC, Hamdam J, Sharpe ME, Patel S, Jones DR, Reinhardt J, Danen EH, Ben-David U, Stacey G, Björquist P, Piner J, Mills J, Rowe C, Pellegrini G, Sethu S, Antoine DJ, Cross MJ, Murray P, Williams DP, Kitteringham NR, Goldring CE, Park BK.

Stem Cells Transl Med. 2015 Apr;4(4):389-400. doi: 10.5966/sctm.2014-0110. Epub 2015 Feb 26. Review.

18.

The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions.

Balcioglu HE, van Hoorn H, Donato DM, Schmidt T, Danen EH.

J Cell Sci. 2015 Apr 1;128(7):1316-26. doi: 10.1242/jcs.156950. Epub 2015 Feb 6.

19.

The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.

von Stechow L, Typas D, Carreras Puigvert J, Oort L, Siddappa R, Pines A, Vrieling H, van de Water B, Mullenders LH, Danen EH.

Mol Cell Biol. 2015 Apr;35(7):1254-68. doi: 10.1128/MCB.01152-14. Epub 2015 Jan 26.

20.

SYK is a candidate kinase target for the treatment of advanced prostate cancer.

Ghotra VP, He S, van der Horst G, Nijhoff S, de Bont H, Lekkerkerker A, Janssen R, Jenster G, van Leenders GJ, Hoogland AM, Verhoef EI, Baranski Z, Xiong J, van de Water B, van der Pluijm G, Snaar-Jagalska BE, Danen EH.

Cancer Res. 2015 Jan 1;75(1):230-40. doi: 10.1158/0008-5472.CAN-14-0629. Epub 2014 Nov 11.

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