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Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes.

Koedoot E, Fokkelman M, Rogkoti VM, Smid M, van de Sandt I, de Bont H, Pont C, Klip JE, Wink S, Timmermans MA, Wiemer EAC, Stoilov P, Foekens JA, Le Dévédec SE, Martens JWM, van de Water B.

Nat Commun. 2019 Jul 5;10(1):2983. doi: 10.1038/s41467-019-11020-3.


Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAs.

Amirnasr A, Gits CMM, van Kuijk PF, Smid M, Vriends ALM, Rutkowski P, Sciot R, Schöffski P, Debiec-Rychter M, Sleijfer S, Wiemer EAC.

Cancers (Basel). 2019 Jun 24;11(6). pii: E882. doi: 10.3390/cancers11060882.


Aberrant MicroRNA Expression and Its Implications for Uveal Melanoma Metastasis.

Smit KN, Chang J, Derks K, Vaarwater J, Brands T, Verdijk RM, Wiemer EAC, Mensink HW, Pothof J, de Klein A, Kilic E.

Cancers (Basel). 2019 Jun 12;11(6). pii: E815. doi: 10.3390/cancers11060815.


Activated Signaling Pathways and Targeted Therapies in Desmoid-Type Fibromatosis: A Literature Review.

Timbergen MJM, Smits R, Grünhagen DJ, Verhoef C, Sleijfer S, Wiemer EAC.

Front Oncol. 2019 May 17;9:397. doi: 10.3389/fonc.2019.00397. eCollection 2019. Review.


MicroRNAs as possible indicators of drug sensitivity in breast cancer cell lines.

Uhr K, Prager-van der Smissen WJC, Heine AAJ, Ozturk B, van Jaarsveld MTM, Boersma AWM, Jager A, Wiemer EAC, Smid M, Foekens JA, Martens JWM.

PLoS One. 2019 May 7;14(5):e0216400. doi: 10.1371/journal.pone.0216400. eCollection 2019.


Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.

Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, Tong X, Chen L, Liu X, Zhang Y, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Xu Y, Chen Q.

Nat Commun. 2019 Apr 17;10(1):1801. doi: 10.1038/s41467-019-09588-x.


Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21.

van Jaarsveld MTM, Deng D, Wiemer EAC, Zi Z.

iScience. 2019 Feb 22;12:27-40. doi: 10.1016/j.isci.2019.01.001. Epub 2019 Jan 5.


Wnt targets genes are not differentially expressed in desmoid tumors bearing different activating β-catenin mutations.

Timbergen MJM, Janssen ML, Verhoef C, Grünhagen DJ, Chibon F, Smid M, Sleijfer S, Wiemer EAC.

Eur J Surg Oncol. 2019 Apr;45(4):691-698. doi: 10.1016/j.ejso.2018.09.019. Epub 2018 Oct 18.


The versatile nature of miR-9/9* in human cancer.

Nowek K, Wiemer EAC, Jongen-Lavrencic M.

Oncotarget. 2018 Apr 17;9(29):20838-20854. doi: 10.18632/oncotarget.24889. eCollection 2018 Apr 17. Review.


Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity.

Ip JPK, Nagakura I, Petravicz J, Li K, Wiemer EAC, Sur M.

J Neurosci. 2018 Apr 18;38(16):3890-3900. doi: 10.1523/JNEUROSCI.2034-17.2018. Epub 2018 Mar 14.


Prognostic Circulating MicroRNA Biomarkers in Early-Stage Non-Small Cell Lung Cancer: A Role for miR-150.

Wiemer EAC.

Clin Pharmacol Ther. 2018 Jun;103(6):968-970. doi: 10.1002/cpt.972. Epub 2017 Dec 29.


Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors.

Amirnasr A, Verdijk RM, van Kuijk PF, Taal W, Sleijfer S, Wiemer EAC.

PLoS One. 2017 Aug 15;12(8):e0183155. doi: 10.1371/journal.pone.0183155. eCollection 2017.


Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: Translational results of the EORTC 62052 trial.

Wiemer EAC, Wozniak A, Burger H, Smid M, Floris G, Nzokirantevye A, Sciot R, Sleijfer S, Schöffski P.

Eur J Cancer. 2017 Apr;75:33-40. doi: 10.1016/j.ejca.2016.12.018. Epub 2017 Feb 16.


MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells.

Nyhan MJ, O'Donovan TR, Boersma AW, Wiemer EA, McKenna SL.

BMC Cancer. 2016 Feb 15;16:101. doi: 10.1186/s12885-016-2123-6.


Inducible Major Vault Protein Plays a Pivotal Role in Double-Stranded RNA- or Virus-Induced Proinflammatory Response.

Peng N, Liu S, Xia Z, Ren S, Feng J, Jing M, Gao X, Wiemer EA, Zhu Y.

J Immunol. 2016 Mar 15;196(6):2753-66. doi: 10.4049/jimmunol.1501481. Epub 2016 Feb 3.


Macrocytosis as a potential parameter associated with survival after tyrosine kinase inhibitor treatment.

Kloth JSL, Hamberg P, Mendelaar PAJ, Dulfer RR, van der Holt B, Eechoute K, Wiemer EAC, Kruit WHJ, Sleijfer S, Mathijssen RHJ.

Eur J Cancer. 2016 Mar;56:101-106. doi: 10.1016/j.ejca.2015.12.019. Epub 2016 Feb 1.


miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway.

van Jaarsveld MT, van Kuijk PF, Boersma AW, Helleman J, van IJcken WF, Mathijssen RH, Pothof J, Berns EM, Verweij J, Wiemer EA.

Mol Cancer. 2015 Nov 17;14:196. doi: 10.1186/s12943-015-0464-4.


Fasting protects against the side effects of irinotecan treatment but does not affect anti-tumour activity in mice.

Huisman SA, de Bruijn P, Ghobadi Moghaddam-Helmantel IM, IJzermans JN, Wiemer EA, Mathijssen RH, de Bruin RW.

Br J Pharmacol. 2016 Mar;173(5):804-14. doi: 10.1111/bph.13317. Epub 2016 Feb 8.


4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes.

de Graan AJ, Sparreboom A, de Bruijn P, de Jonge E, van der Holt B, Wiemer EA, Verweij J, Mathijssen RH, van Schaik RH.

Br J Clin Pharmacol. 2015 Sep;80(3):560-8. doi: 10.1111/bcp.12707. Epub 2015 Aug 12.

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