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Items: 1 to 20 of 134


Heavy metal protease takes a tiki torch to HIV assembly.

O'Doherty U, Freed EO.

Nat Immunol. 2019 Jun;20(6):668-669. doi: 10.1038/s41590-019-0387-0. No abstract available.


Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle.

Novikova M, Zhang Y, Freed EO, Peng K.

Virol Sin. 2019 Apr;34(2):119-134. doi: 10.1007/s12250-019-00095-3. Epub 2019 Apr 26. Review.


Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle.

Van Duyne R, Kuo LS, Pham P, Fujii K, Freed EO.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9040-9049. doi: 10.1073/pnas.1820333116. Epub 2019 Apr 11.


TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins.

Li M, Waheed AA, Yu J, Zeng C, Chen HY, Zheng YM, Feizpour A, Reinhard BM, Gummuluru S, Lin S, Freed EO, Liu SL.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5705-5714. doi: 10.1073/pnas.1819475116. Epub 2019 Mar 6.


Resistance to Second-Generation HIV-1 Maturation Inhibitors.

Urano E, Timilsina U, Kaplan JA, Ablan S, Ghimire D, Pham P, Kuruppu N, Mandt R, Durell SR, Nitz TJ, Martin DE, Wild CT, Gaur R, Freed EO.

J Virol. 2019 Mar 5;93(6). pii: e02017-18. doi: 10.1128/JVI.02017-18. Print 2019 Mar 15.


Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes.

Uhl J, Gujarathi S, Waheed AA, Gordon A, Freed EO, Gousset K.

J Cell Commun Signal. 2019 Jun;13(2):209-224. doi: 10.1007/s12079-018-0493-z. Epub 2018 Nov 15.


Meeting Review: 2018 International Workshop on Structure and Function of the Lentiviral gp41 Cytoplasmic Tail.

Fernandez MV, Freed EO.

Viruses. 2018 Nov 7;10(11). pii: E613. doi: 10.3390/v10110613.


Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.

Novikova M, Adams LJ, Fontana J, Gres AT, Balasubramaniam M, Winkler DC, Kudchodkar SB, Soheilian F, Sarafianos SG, Steven AC, Freed EO.

MBio. 2018 Oct 16;9(5). pii: e01567-18. doi: 10.1128/mBio.01567-18.


HIV-1 packs in PACSIN2 for cell-to-cell spread.

Van Duyne R, Freed EO.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):6885-6887. doi: 10.1073/pnas.1808821115. Epub 2018 Jun 20. No abstract available.


Single molecule fate of HIV-1 envelope reveals late-stage viral lattice incorporation.

Buttler CA, Pezeshkian N, Fernandez MV, Aaron J, Norman S, Freed EO, van Engelenburg SB.

Nat Commun. 2018 May 10;9(1):1861. doi: 10.1038/s41467-018-04220-w.


High-Mannose But Not Complex-Type Glycosylation of Tetherin Is Required for Restriction of HIV-1 Release.

Waheed AA, Gitzen A, Swiderski M, Freed EO.

Viruses. 2018 Jan 5;10(1). pii: E26. doi: 10.3390/v10010026.


Quenching protein dynamics interferes with HIV capsid maturation.

Wang M, Quinn CM, Perilla JR, Zhang H, Shirra R Jr, Hou G, Byeon IJ, Suiter CL, Ablan S, Urano E, Nitz TJ, Aiken C, Freed EO, Zhang P, Schulten K, Gronenborn AM, Polenova T.

Nat Commun. 2017 Nov 24;8(1):1779. doi: 10.1038/s41467-017-01856-y.


Intracellular Reassociation of RNA-DNA Hybrids that Activates RNAi in HIV-Infected Cells.

Martins AN, Ke W, Jawahar V, Striplin M, Striplin C, Freed EO, Afonin KA.

Methods Mol Biol. 2017;1632:269-283. doi: 10.1007/978-1-4939-7138-1_18.


"Expand and Click": A New Method for Labeling HIV-1 Envelope Glycoproteins.

Fernandez MV, Freed EO.

Cell Chem Biol. 2017 May 18;24(5):548-550. doi: 10.1016/j.chembiol.2017.05.006.


A Triazinone Derivative Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity.

Urano E, Miyauchi K, Kojima Y, Hamatake M, Ablan SD, Fudo S, Freed EO, Hoshino T, Komano J.

ChemMedChem. 2016 Oct 19;11(20):2320-2326. doi: 10.1002/cmdc.201600375. Epub 2016 Sep 16.


Getting IN on Viral RNA Condensation and Virion Maturation.

Freed EO.

Cell. 2016 Aug 25;166(5):1082-1083. doi: 10.1016/j.cell.2016.08.013.


Identification of potent maturation inhibitors against HIV-1 clade C.

Timilsina U, Ghimire D, Timalsina B, Nitz TJ, Wild CT, Freed EO, Gaur R.

Sci Rep. 2016 Jun 6;6:27403. doi: 10.1038/srep27403.


The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species.

Waheed AA, MacDonald S, Khan M, Mounts M, Swiderski M, Xu Y, Ye Y, Freed EO.

Sci Rep. 2016 Apr 22;6:24934. doi: 10.1038/srep24934.


Trimer Enhancement Mutation Effects on HIV-1 Matrix Protein Binding Activities.

Alfadhli A, Mack A, Ritchie C, Cylinder I, Harper L, Tedbury PR, Freed EO, Barklis E.

J Virol. 2016 May 27;90(12):5657-5664. doi: 10.1128/JVI.00509-16. Print 2016 Jun 15.


Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein.

Mercredi PY, Bucca N, Loeliger B, Gaines CR, Mehta M, Bhargava P, Tedbury PR, Charlier L, Floquet N, Muriaux D, Favard C, Sanders CR, Freed EO, Marchant J, Summers MF.

J Mol Biol. 2016 Apr 24;428(8):1637-55. doi: 10.1016/j.jmb.2016.03.005. Epub 2016 Mar 16.

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