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Items: 1 to 20 of 46

1.

Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals.

Cummins EP, Strowitzki MJ, Taylor CT.

Physiol Rev. 2020 Jan 1;100(1):463-488. doi: 10.1152/physrev.00003.2019. Epub 2019 Sep 20.

PMID:
31539306
2.

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Strowitzki MJ, Cummins EP, Taylor CT.

Cells. 2019 Apr 26;8(5). pii: E384. doi: 10.3390/cells8050384. Review.

3.

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes.

Crifo B, Schaible B, Brown E, Halligan DN, Scholz CC, Fitzpatrick SF, Kirwan A, Roche HM, Criscuoli M, Naldini A, Giffney H, Crean D, Blanco A, Cavadas MA, Cummins EP, Fabian Z, Taylor CT.

J Immunol. 2019 Mar 1;202(5):1521-1530. doi: 10.4049/jimmunol.1800912. Epub 2019 Jan 30.

PMID:
30700584
4.

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.

Keogh CE, Scholz CC, Rodriguez J, Selfridge AC, von Kriegsheim A, Cummins EP.

J Biol Chem. 2017 Jul 7;292(27):11561-11571. doi: 10.1074/jbc.M116.755090. Epub 2017 May 15.

5.

Physiological gases in health and disease - key regulatory factors, not just a lot of hot air.

Cummins EP.

J Physiol. 2017 Apr 15;595(8):2421-2422. doi: 10.1113/JP274042. No abstract available.

6.

NR4A Receptors Differentially Regulate NF-κB Signaling in Myeloid Cells.

McEvoy C, de Gaetano M, Giffney HE, Bahar B, Cummins EP, Brennan EP, Barry M, Belton O, Godson CG, Murphy EP, Crean D.

Front Immunol. 2017 Jan 23;8:7. doi: 10.3389/fimmu.2017.00007. eCollection 2017.

7.

Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7778-E7787. Epub 2016 Nov 15.

8.

Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected].

Manresa MC, Tambuwala MM, Radhakrishnan P, Harnoss JM, Brown E, Cavadas MA, Keogh CE, Cheong A, Barrett KE, Cummins EP, Schneider M, Taylor CT.

Am J Physiol Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1076-G1090. doi: 10.1152/ajpgi.00229.2016. Epub 2016 Oct 27. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2017 Apr 1;312(4):G405.

9.

Hypoxia and inflammatory bowel disease.

Cummins EP, Crean D.

Microbes Infect. 2017 Mar;19(3):210-221. doi: 10.1016/j.micinf.2016.09.004. Epub 2016 Sep 20. Review.

PMID:
27664046
10.

REST is a hypoxia-responsive transcriptional repressor.

Cavadas MA, Mesnieres M, Crifo B, Manresa MC, Selfridge AC, Keogh CE, Fabian Z, Scholz CC, Nolan KA, Rocha LM, Tambuwala MM, Brown S, Wdowicz A, Corbett D, Murphy KJ, Godson C, Cummins EP, Taylor CT, Cheong A.

Sci Rep. 2016 Aug 17;6:31355. doi: 10.1038/srep31355.

11.

Respiratory gases and the regulation of transcription.

Cummins EP, Keogh CE.

Exp Physiol. 2016 Aug 1;101(8):986-1002. doi: 10.1113/EP085715. Review.

12.

Hypoxia-dependent regulation of inflammatory pathways in immune cells.

Taylor CT, Doherty G, Fallon PG, Cummins EP.

J Clin Invest. 2016 Oct 3;126(10):3716-3724. doi: 10.1172/JCI84433. Epub 2016 Jul 25. Review.

13.

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.

Fitzpatrick SF, Fábián Z, Schaible B, Lenihan CR, Schwarzl T, Rodriguez J, Zheng X, Li Z, Tambuwala MM, Higgins DG, O'Meara Y, Slattery C, Manresa MC, Fraisl P, Bruning U, Baes M, Carmeliet P, Doherty G, von Kriegsheim A, Cummins EP, Taylor CT.

Biochem Biophys Res Commun. 2016 Jun 3;474(3):579-586. doi: 10.1016/j.bbrc.2016.04.085. Epub 2016 Apr 27.

14.

Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.

Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45. doi: 10.1152/ajprenal.00136.2016. Epub 2016 Apr 27.

15.

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.

Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT.

J Biol Chem. 2016 May 27;291(22):11800-8. doi: 10.1074/jbc.M116.713941. Epub 2016 Apr 4.

16.

The role of HIF in immunity and inflammation.

Cummins EP, Keogh CE, Crean D, Taylor CT.

Mol Aspects Med. 2016 Feb-Mar;47-48:24-34. doi: 10.1016/j.mam.2015.12.004. Epub 2016 Jan 6. Review.

PMID:
26768963
17.

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

Scholz CC, Rodriguez J, Pickel C, Burr S, Fabrizio JA, Nolan KA, Spielmann P, Cavadas MA, Crifo B, Halligan DN, Nathan JA, Peet DJ, Wenger RH, Von Kriegsheim A, Cummins EP, Taylor CT.

PLoS Biol. 2016 Jan 11;14(1):e1002347. doi: 10.1371/journal.pbio.1002347. eCollection 2016 Jan.

18.

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.

Cavadas MA, Mesnieres M, Crifo B, Manresa MC, Selfridge AC, Scholz CC, Cummins EP, Cheong A, Taylor CT.

Sci Rep. 2015 Dec 9;5:17851. doi: 10.1038/srep17851.

19.

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis.

Tambuwala MM, Manresa MC, Cummins EP, Aversa V, Coulter IS, Taylor CT.

J Control Release. 2015 Nov 10;217:221-7. doi: 10.1016/j.jconrel.2015.09.022. Epub 2015 Sep 16.

PMID:
26385165
20.

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells.

Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP.

J Immunol. 2015 Aug 15;195(4):1436-48. doi: 10.4049/jimmunol.1402039. Epub 2015 Jul 6.

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