Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 220

1.

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.

Lima BHF, Marques PE, Gomides LF, Mattos MS, Kraemer L, Queiroz-Junior CM, Lennon M, Hirsch E, Russo RC, Menezes GB, Hessel EM, Amour A, Teixeira MM.

Sci Rep. 2019 Dec 13;9(1):19085. doi: 10.1038/s41598-019-55504-0.

PMID:
31836766
2.

Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth.

Cisse O, Quraishi M, Gulluni F, Guffanti F, Mavrommati I, Suthanthirakumaran M, Oh LCR, Schlatter JN, Sarvananthan A, Broggini M, Hirsch E, Falasca M, Maffucci T.

J Exp Clin Cancer Res. 2019 Nov 21;38(1):472. doi: 10.1186/s13046-019-1472-9.

3.

The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium.

Margaria JP, Campa CC, De Santis MC, Hirsch E, Franco I.

Cell Signal. 2019 Nov 9;66:109468. doi: 10.1016/j.cellsig.2019.109468. [Epub ahead of print]

PMID:
31715259
4.

DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls.

Brites-Anselmi G, Azevedo AMM, Miyazaki AHL, Pinheiro LC, Coeli-Lacchini FB, de Andrade MF, Molina CAF, Tucci S Jr, Hirsch E, Tanus-Santos JE, Lacchini R.

Nitric Oxide. 2019 Nov 1;92:11-17. doi: 10.1016/j.niox.2019.08.001. Epub 2019 Aug 5.

PMID:
31394201
5.

Mechanisms underlying the cross-talk between heart and cancer.

Brancaccio M, Pirozzi F, Hirsch E, Ghigo A.

J Physiol. 2019 Jul 6. doi: 10.1113/JP276746. [Epub ahead of print]

PMID:
31278748
6.

p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.

Torres C, Mancinelli G, Cordoba-Chacon J, Viswakarma N, Castellanos K, Grimaldo S, Kumar S, Principe D, Dorman MJ, McKinney R, Hirsch E, Dawson D, Munshi HG, Rana A, Grippo PJ.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14724-14733. doi: 10.1073/pnas.1813012116. Epub 2019 Jul 2.

PMID:
31266893
7.

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response.

Lupieri A, Smirnova NF, Solinhac R, Malet N, Benamar M, Saoudi A, Santos-Zas I, Zeboudj L, Ait-Oufella H, Hirsch E, Ohayon P, Lhermusier T, Carrié D, Arnal JF, Ramel D, Gayral S, Laffargue M.

Cardiovasc Res. 2019 May 20. pii: cvz122. doi: 10.1093/cvr/cvz122. [Epub ahead of print]

PMID:
31106375
8.

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction.

Tiosano D, Baris HN, Chen A, Hitzert MM, Schueler M, Gulluni F, Wiesener A, Bergua A, Mory A, Copeland B, Gleeson JG, Rump P, van Meer H, Sival DA, Haucke V, Kriwinsky J, Knaup KX, Reis A, Hauer NN, Hirsch E, Roepman R, Pfundt R, Thiel CT, Wiesener MS, Aslanyan MG, Buchner DA.

PLoS Genet. 2019 Apr 29;15(4):e1008088. doi: 10.1371/journal.pgen.1008088. eCollection 2019 Apr.

9.

Targeting PI3K signaling in cancer: Challenges and advances.

De Santis MC, Gulluni F, Campa CC, Martini M, Hirsch E.

Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):361-366. doi: 10.1016/j.bbcan.2019.03.003. Epub 2019 Apr 1. Review.

PMID:
30946868
10.

Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking.

Margaria JP, Ratto E, Gozzelino L, Li H, Hirsch E.

Biomolecules. 2019 Mar 15;9(3). pii: E104. doi: 10.3390/biom9030104. Review.

11.

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity.

Russo M, Guida F, Paparo L, Trinchese G, Aitoro R, Avagliano C, Fiordelisi A, Napolitano F, Mercurio V, Sala V, Li M, Sorriento D, Ciccarelli M, Ghigo A, Hirsch E, Bianco R, Iaccarino G, Abete P, Bonaduce D, Calignano A, Berni Canani R, Tocchetti CG.

Eur J Heart Fail. 2019 Apr;21(4):519-528. doi: 10.1002/ejhf.1439. Epub 2019 Mar 6.

PMID:
30843309
12.

New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole.

Dos Santos Nascimento MVP, Mattar Munhoz AC, De Campos Facchin BM, Fratoni E, Rossa TA, Mandolesi Sá M, Campa CC, Ciraolo E, Hirsch E, Dalmarco EM.

Biomed Pharmacother. 2019 Mar;111:1399-1407. doi: 10.1016/j.biopha.2019.01.052. Epub 2019 Jan 19.

13.

Late onset heart failure after childhood chemotherapy.

Hilfiker-Kleiner D, Ardehali H, Fischmeister R, Burridge P, Hirsch E, Lyon AR.

Eur Heart J. 2019 Mar 7;40(10):798-800. doi: 10.1093/eurheartj/ehz046. No abstract available.

PMID:
30753420
14.

Class II PI3K Functions in Cell Biology and Disease.

Gulluni F, De Santis MC, Margaria JP, Martini M, Hirsch E.

Trends Cell Biol. 2019 Apr;29(4):339-359. doi: 10.1016/j.tcb.2019.01.001. Epub 2019 Jan 25. Review.

PMID:
30691999
15.

The Inhibition of Phosphoinositide-3 Kinases Induce Resolution of Inflammation in a Gout Model.

Galvão I, Queiroz-Junior CM, de Oliveira VLS, Pinho V, Hirsch E, Teixeira MM.

Front Pharmacol. 2019 Jan 7;9:1505. doi: 10.3389/fphar.2018.01505. eCollection 2018.

16.

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.

17.

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE.

Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z.

18.

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.

Zamboni V, Jones R, Umbach A, Ammoni A, Passafaro M, Hirsch E, Merlo GR.

Int J Mol Sci. 2018 Jun 20;19(6). pii: E1821. doi: 10.3390/ijms19061821. Review.

19.

Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.

Campa CC, Margaria JP, Derle A, Del Giudice M, De Santis MC, Gozzelino L, Copperi F, Bosia C, Hirsch E.

Nat Chem Biol. 2018 Aug;14(8):801-810. doi: 10.1038/s41589-018-0086-4. Epub 2018 Jun 18.

PMID:
29915378
20.

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR.

Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3.

Supplemental Content

Loading ...
Support Center