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Future Med Chem. 2019 May;11(10):1157-1175. doi: 10.4155/fmc-2018-0463.

Fluorinated MRI contrast agents and their versatile applications in the biomedical field.

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General, Organic & Biomedical Chemistry Unit, Nuclear Magnetic Resonance (NMR) & Molecular Imaging Laboratory, University of Mons (UMONS), Avenue Victor Maistriau 19, 7000 Mons, Belgium.
CMMI (UMONS) - Center for Microscopy & Molecular Imaging, MRI, Optoacoustic and Optical Imaging, Rue Adrienne Bolland 8, 6041 Gosselies, Belgium.


MRI has been recognized as one of the most applied medical imaging techniques in clinical practice. However, the presence of background signal coming from water protons in surrounding tissues makes sometimes the visualization of local contrast agents difficult. To remedy this, fluorine has been introduced as a reliable perspective, thanks to its magnetic properties being relatively close to those of protons. In this review, we aim to give an overall description of fluorine incorporation in contrast agents for MRI. The different kinds of fluorinated probes such as perfluorocarbons, fluorinated dendrimers, polymers and paramagnetic probes will be described, as will their imaging applications such as chemical exchange saturation transfer (CEST) imaging, physico-chemical changes detection, drug delivery, cell tracking and inflammation or tumors detection.


MRI; PFC; cell tracking; contrast agents; drug delivery; fluorine; gadolinium complexes; medical imaging; paramagnetic compounds

[Indexed for MEDLINE]

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