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Items: 1 to 20 of 30

1.

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.

Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL, Pitkänen A.

Int J Mol Sci. 2019 Oct 29;20(21). pii: E5395. doi: 10.3390/ijms20215395.

2.

Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.

Jobbagy S, Vitturi DA, Salvatore SR, Turell L, Pires MF, Kansanen E, Batthyany C, Lancaster JR Jr, Freeman BA, Schopfer FJ.

Redox Biol. 2019 Feb;21:101050. doi: 10.1016/j.redox.2018.11.008. Epub 2018 Nov 22.

3.

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells.

Kuosmanen SM, Sihvola V, Kansanen E, Kaikkonen MU, Levonen AL.

Redox Biol. 2018 Sep;18:77-83. doi: 10.1016/j.redox.2018.06.007. Epub 2018 Jun 22.

4.

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice.

Ruotsalainen AK, Lappalainen JP, Heiskanen E, Merentie M, Sihvola V, Näpänkangas J, Lottonen-Raikaslehto L, Kansanen E, Adinolfi S, Kaarniranta K, Ylä-Herttuala S, Jauhiainen M, Pirinen E, Levonen AL.

Cardiovasc Res. 2019 Jan 1;115(1):243-254. doi: 10.1093/cvr/cvy143.

PMID:
29917052
5.

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation.

Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen HK, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokki H, Tavi P, Heikkinen S, Levonen AL.

Nucleic Acids Res. 2018 Feb 16;46(3):1124-1138. doi: 10.1093/nar/gkx1155.

6.

MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells.

Kuosmanen SM, Kansanen E, Sihvola V, Levonen AL.

Sci Rep. 2017 Sep 8;7(1):10943. doi: 10.1038/s41598-017-11487-4.

7.

Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells.

Kansanen E, Kuosmanen SM, Ruotsalainen AK, Hynynen H, Levonen AL.

Mol Pharmacol. 2017 Oct;92(4):481-490. doi: 10.1124/mol.117.109751. Epub 2017 Aug 4.

PMID:
28778983
8.

The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs.

Kuosmanen SM, Viitala S, Laitinen T, Peräkylä M, Pölönen P, Kansanen E, Leinonen H, Raju S, Wienecke-Baldacchino A, Närvänen A, Poso A, Heinäniemi M, Heikkinen S, Levonen AL.

Nucleic Acids Res. 2016 Feb 29;44(4):1760-75. doi: 10.1093/nar/gkw052. Epub 2016 Jan 29.

9.

Dysregulation of the Keap1-Nrf2 pathway in cancer.

Leinonen HM, Kansanen E, Pölönen P, Heinäniemi M, Levonen AL.

Biochem Soc Trans. 2015 Aug;43(4):645-9. doi: 10.1042/BST20150048. Epub 2015 Aug 3. Review.

PMID:
26551706
10.

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization.

Kaikkonen MU, Niskanen H, Romanoski CE, Kansanen E, Kivelä AM, Laitalainen J, Heinz S, Benner C, Glass CK, Ylä-Herttuala S.

Nucleic Acids Res. 2014 Nov 10;42(20):12570-84. doi: 10.1093/nar/gku1036. Epub 2014 Oct 28.

11.

HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.

Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, Rissanen TT, André H, Pereira T, Poellinger L, Alitalo K, Ylä-Herttuala S.

Eur J Clin Invest. 2014 Oct;44(10):989-99. doi: 10.1111/eci.12333.

PMID:
25208310
12.

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT.

Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19.

PMID:
25140003
13.

Role of the Keap1-Nrf2 pathway in cancer.

Leinonen HM, Kansanen E, Pölönen P, Heinäniemi M, Levonen AL.

Adv Cancer Res. 2014;122:281-320. doi: 10.1016/B978-0-12-420117-0.00008-6. Review.

PMID:
24974185
14.

Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.

Levonen AL, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM.

Free Radic Biol Med. 2014 Jun;71:196-207. doi: 10.1016/j.freeradbiomed.2014.03.025. Epub 2014 Mar 26. Review.

15.

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.

Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL.

Redox Biol. 2013 Jan 18;1:45-9. doi: 10.1016/j.redox.2012.10.001. Review.

16.

The absence of macrophage Nrf2 promotes early atherogenesis.

Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL.

Cardiovasc Res. 2013 Apr 1;98(1):107-15. doi: 10.1093/cvr/cvt008. Epub 2013 Jan 22.

PMID:
23341579
17.

Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.

Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB.

J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11.

18.

Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.

Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL.

Cancer Res. 2012 Dec 1;72(23):6227-35. doi: 10.1158/0008-5472.CAN-12-1166. Epub 2012 Oct 4.

19.

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids.

Kansanen E, Jyrkkänen HK, Levonen AL.

Free Radic Biol Med. 2012 Mar 15;52(6):973-82. doi: 10.1016/j.freeradbiomed.2011.11.038. Epub 2011 Dec 13. Review.

PMID:
22198184
20.

Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2.

Jyrkkänen HK, Kuosmanen S, Heinäniemi M, Laitinen H, Kansanen E, Mella-Aho E, Leinonen H, Ylä-Herttuala S, Levonen AL.

Biochem J. 2011 Dec 1;440(2):167-74. doi: 10.1042/BJ20110526.

PMID:
21812759

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