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Fast and highly efficient affinity enrichment of Azide-A-DSBSO cross-linked peptides.

Matzinger M, Kandioller W, Doppler P, Heiss EH, Mechtler K.

J Proteome Res. 2020 Apr 6. doi: 10.1021/acs.jproteome.0c00003. [Epub ahead of print]


AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes.

Matzinger M, Fischhuber K, Pölöske D, Mechtler K, Heiss EH.

Redox Biol. 2020 Jan;29:101393. doi: 10.1016/j.redox.2019.101393. Epub 2019 Nov 27.


Impact of natural products on the cholesterol transporter ABCA1.

Wang D, Hiebl V, Xu T, Ladurner A, Atanasov AG, Heiss EH, Dirsch VM.

J Ethnopharmacol. 2020 Mar 1;249:112444. doi: 10.1016/j.jep.2019.112444. Epub 2019 Dec 2. Review.


Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture.

Joa H, Blažević T, Grojer C, Zeller I, Heiss EH, Atanasov AG, Feldler I, Gruzdaitis P, Czaloun C, Proksch P, Messner B, Bernhard D, Dirsch VM.

Phytomedicine. 2019 Jul;60:152938. doi: 10.1016/j.phymed.2019.152938. Epub 2019 Apr 23.


Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells.

Woelflingseder L, Del Favero G, Blažević T, Heiss EH, Haider M, Warth B, Adam G, Marko D.

Toxicol Lett. 2018 Dec 15;299:104-117. doi: 10.1016/j.toxlet.2018.09.007. Epub 2018 Sep 20.


Dihydrochalcone Glucosides from the Subaerial Parts of Thonningia sanguinea and Their in Vitro PTP1B Inhibitory Activities.

Pompermaier L, Heiss EH, Alilou M, Mayr F, Monizi M, Lautenschlaeger T, Schuster D, Schwaiger S, Stuppner H.

J Nat Prod. 2018 Sep 28;81(9):2091-2100. doi: 10.1021/acs.jnatprod.8b00450. Epub 2018 Sep 12.


Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.

Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG.

Sci Rep. 2018 Jul 23;8(1):11061. doi: 10.1038/s41598-018-29281-1.


6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

Wang D, Hiebl V, Ladurner A, Latkolik SL, Bucar F, Heiß EH, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2018 May 26:e1800011. doi: 10.1002/mnfr.201800011. [Epub ahead of print]


Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor.

Liu R, Heiss EH, Waltenberger B, Blažević T, Schachner D, Jiang B, Krystof V, Liu W, Schwaiger S, Peña-Rodríguez LM, Breuss JM, Stuppner H, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2018 Apr;62(7):e1700860. doi: 10.1002/mnfr.201700860. Epub 2018 Mar 30.


Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Matzinger M, Fischhuber K, Heiss EH.

Biotechnol Adv. 2018 Nov 1;36(6):1738-1767. doi: 10.1016/j.biotechadv.2017.12.015. Epub 2017 Dec 28. Review.


Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level.

Malainer C, Schachner D, Sangiovanni E, Atanasov AG, Schwaiger S, Stuppner H, Heiss EH, Dirsch VM.

J Nat Prod. 2017 Dec 22;80(12):3186-3193. doi: 10.1021/acs.jnatprod.7b00503. Epub 2017 Nov 17.


Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation.

Dreier D, Latkolik S, Rycek L, Schnürch M, Dymáková A, Atanasov AG, Ladurner A, Heiss EH, Stuppner H, Schuster D, Mihovilovic MD, Dirsch VM.

Sci Rep. 2017 Oct 20;7(1):13002. doi: 10.1038/s41598-017-12628-5.


An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages.

Boakye YD, Groyer L, Heiss EH.

Biochim Biophys Acta Gen Subj. 2018 Jan;1862(1):61-70. doi: 10.1016/j.bbagen.2017.10.006. Epub 2017 Oct 12.


The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability.

Wang L, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Bauer R, Dirsch VM, Atanasov AG.

Front Pharmacol. 2017 Sep 1;8:596. doi: 10.3389/fphar.2017.00596. eCollection 2017.


Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF-κB Inhibitors.

Liu X, Latkolik S, Atanasov AG, Kunert O, Pferschy-Wenzig EM, Heiss EH, Malainer C, Schinkovitz A, Kollroser M, Dirsch VM, Bauer R.

Planta Med. 2017 Oct;83(14-15):1242-1250. doi: 10.1055/s-0043-118226. Epub 2017 Sep 8.


Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

Wang L, Wesemann S, Krenn L, Ladurner A, Heiss EH, Dirsch VM, Atanasov AG.

Front Pharmacol. 2017 Jun 13;8:375. doi: 10.3389/fphar.2017.00375. eCollection 2017.


Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo.

Liu R, Heiss EH, Schachner D, Jiang B, Liu W, Breuss JM, Dirsch VM, Atanasov AG.

J Nat Prod. 2017 Jul 28;80(7):2146-2150. doi: 10.1021/acs.jnatprod.7b00268. Epub 2017 Jun 19.


Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.

Wang D, Tosevska A, Heiß EH, Ladurner A, Mölzer C, Wallner M, Bulmer A, Wagner KH, Dirsch VM, Atanasov AG.

J Am Heart Assoc. 2017 Apr 28;6(5). pii: e005520. doi: 10.1161/JAHA.117.005520.


Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.

Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201500960. Epub 2016 Dec 23.

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