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Items: 1 to 20 of 28


HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models.

Torresi J, Tran BM, Christiansen D, Earnest-Silveira L, Schwab RHM, Vincan E.

BMC Cancer. 2019 Jul 18;19(1):707. doi: 10.1186/s12885-019-5916-6. Review.


The Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo.

Flanagan D, Barker N, Ernst M, Vincan E, Phesse T.

Biomedicines. 2019 Jul 8;7(3). pii: E50. doi: 10.3390/biomedicines7030050.


Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations.

Flanagan DJ, Barker N, Costanzo NSD, Mason EA, Gurney A, Meniel VS, Koushyar S, Austin CR, Ernst M, Pearson HB, Boussioutas A, Clevers H, Phesse TJ, Vincan E.

Cancer Res. 2019 Mar 1;79(5):970-981. doi: 10.1158/0008-5472.CAN-18-2095. Epub 2019 Jan 8.


PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein.

Daniel PM, Filiz G, Brown DV, Christie M, Waring PM, Zhang Y, Haynes JM, Pouton C, Flanagan D, Vincan E, Johns TG, Montgomery K, Phillips WA, Mantamadiotis T.

Neuro Oncol. 2018 Sep 3;20(10):1344-1355. doi: 10.1093/neuonc/noy068.


Wnt Signalling in Gastrointestinal Epithelial Stem Cells.

Flanagan DJ, Austin CR, Vincan E, Phesse TJ.

Genes (Basel). 2018 Mar 23;9(4). pii: E178. doi: 10.3390/genes9040178. Review.


The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy.

Vincan E, Schwab RHM, Flanagan DJ, Moselen JM, Tran BM, Barker N, Phesse TJ.

Prog Mol Biol Transl Sci. 2018 Jan;153:299-319. doi: 10.1016/bs.pmbts.2017.11.009. Epub 2017 Dec 21. Review.


Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.

Flanagan DJ, Barker N, Nowell C, Clevers H, Ernst M, Phesse TJ, Vincan E.

Dis Model Mech. 2017 Aug 1;10(8):971-980. doi: 10.1242/dmm.029876. Epub 2017 Jun 9.


Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers.

Flanagan DJ, Vincan E, Phesse TJ.

Br J Pharmacol. 2017 Dec;174(24):4666-4683. doi: 10.1111/bph.13890. Epub 2017 Jul 5. Review.


Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.

Schwab RHM, Amin N, Flanagan DJ, Johanson TM, Phesse TJ, Vincan E.

Dev Dyn. 2018 Mar;247(3):521-530. doi: 10.1002/dvdy.24527. Epub 2017 Jun 22.


Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion.

Flanagan DJ, Schwab RH, Tran BM, Phesse TJ, Vincan E.

Methods Mol Biol. 2016 Oct 5. [Epub ahead of print]


Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer.

Phesse T, Flanagan D, Vincan E.

Cancers (Basel). 2016 May 17;8(5). pii: E50. doi: 10.3390/cancers8050050. Review.


Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model.

Thiem S, Eissmann MF, Elzer J, Jonas A, Putoczki TL, Poh A, Nguyen P, Preaudet A, Flanagan D, Vincan E, Waring P, Buchert M, Jarnicki A, Ernst M.

Cancer Res. 2016 Apr 15;76(8):2277-87. doi: 10.1158/0008-5472.CAN-15-3089. Epub 2016 Feb 2.


Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E.

Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16.


Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M.

Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411.


The Wnt signaling pathways and cell adhesion.

Amin N, Vincan E.

Front Biosci (Landmark Ed). 2012 Jan 1;17:784-804. Review.


Myb controls intestinal stem cell genes and self-renewal.

Cheasley D, Pereira L, Lightowler S, Vincan E, Malaterre J, Ramsay RG.

Stem Cells. 2011 Dec;29(12):2042-50. doi: 10.1002/stem.761.


Intestinal epithelial-specific PTEN inactivation results in tumor formation.

Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G856-64. doi: 10.1152/ajpgi.00178.2011. Epub 2011 Aug 11.


PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM.

Cancer Res. 2011 May 15;71(10):3709-19. doi: 10.1158/0008-5472.CAN-10-2342. Epub 2011 May 10.


Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment.

Vincan E, Flanagan DJ, Pouliot N, Brabletz T, Spaderna S.

Dev Dyn. 2010 Jan;239(1):311-7. doi: 10.1002/dvdy.22045.


Analysis of Wnt/FZD-mediated signalling in a cell line model of colorectal cancer morphogenesis.

Vincan E, Whitehead RH, Faux MC.

Methods Mol Biol. 2008;468:263-73. doi: 10.1007/978-1-59745-249-6_21.


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