Format

Send to

Choose Destination
Nutrients. 2015 Aug 5;7(8):6520-8. doi: 10.3390/nu7085294.

Effects of a Low Dose of Fish Oil on Inflammatory Markers of Brazilian HIV-Infected Adults on Antiretroviral Therapy: A Randomized, Parallel, Placebo-Controlled Trial.

Author information

1
School of Applied Sciences, University of Campinas, Sao Paulo, 13484-350, Brazil. julicristie.oliveira@fca.unicamp.br.
2
Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, 01246-904, Brazil. phcrondo@usp.br.
3
Laboratory of Immunology, Adolfo Lutz Institute, Sao Paulo, 13036-225, Brazil. lourlima@uol.com.br.
4
University College London, London WC1H 0EG, UK. j.yudkin@ucl.ac.uk.

Abstract

BACKGROUND:

The benefits of antiretroviral therapy for HIV-infected subjects have been limited by an increased risk of metabolic and cardiovascular diseases. The objective of this study was to assess the effects of a low dose of marine omega-3 fatty acids on inflammatory marker concentrations in HIV-infected subjects under antiretroviral therapy (ART).

METHODS:

This was a randomized, parallel, placebo-controlled trial that investigated the effects of 3 g fish oil/day (540 mg of eicosapentaenoic acid-EPA plus 360 mg of docosahexaenoic acid-DHA) or 3 g soy oil/day (placebo) for 24 weeks in 83 male and non-pregnant female HIV-infected adults on ART.

RESULTS:

There were no differences between groups for the measures at baseline. Multilevel analyses revealed no statistically significant relationship between the longitudinal changes in high sensitivity-C reactive protein (hs-CRP) (Wald Chi2 = 0.17, p = 0.918), fibrinogen (Wald Chi2 = 3.82, p = 0.148), and factor VIII (Wald Chi2 = 5.25, p = 0.073) with fish oil. No significant changes in interleukin-6 (IL6), interleukin-1 beta (IL1-beta) and tumor necrosis factor-alpha (TNF-alpha) serum concentrations were observed with fish oil supplements for 12 weeks.

CONCLUSIONS:

Compared to placebo, a low dose of 900 mg omega-3 fatty acids (EPA plus DHA) in fish oil capsules did not change hs-CRP, fibrinogen, factor VIII, IL6, IL1-beta and TNF-alpha serum concentrations in HIV-infected subjects on ART. Further investigations should consider the assessment of more sensitive inflammatory markers or higher doses to evaluate the effects of marine omega-3 fatty acids in this population. Registered at the Nederlands Trial Register, Identifier no. NTR1798.

KEYWORDS:

AIDS; C reactive protein; HIV infection; factor VIII; fibrinogen; inflammation; interleukin 1-beta; interleukin 6; metabolic syndrome; tumor necrosis factor-alpha

PMID:
26251920
PMCID:
PMC4555133
DOI:
10.3390/nu7085294
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center