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Items: 1 to 20 of 69

1.

Three-Year Follow-Up of Phase 1 and 2a rAAV.sFLT-1 Subretinal Gene Therapy Trials for Exudative Age-Related Macular Degeneration.

Rakoczy EP, Magno AL, Lai CM, Pierce CM, Degli-Esposti MA, Blumenkranz MS, Constable IJ.

Am J Ophthalmol. 2019 Aug;204:113-123. doi: 10.1016/j.ajo.2019.03.006. Epub 2019 Mar 13.

PMID:
30878487
2.

Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy.

Herat LY, Matthews VB, Rakoczy PE, Carnagarin R, Schlaich M.

Int J Endocrinol. 2018 Jul 5;2018:9254126. doi: 10.1155/2018/9254126. eCollection 2018. Review.

3.

Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas.

Mugisho OO, Green CR, Zhang J, Binz N, Acosta ML, Rakoczy E, Rupenthal ID.

Int J Mol Sci. 2017 Nov 29;18(12). pii: E2567. doi: 10.3390/ijms18122567.

4.

Gene therapy for the long term treatment of wet AMD.

Rakoczy EP.

Lancet. 2017 Jul 1;390(10089):6-7. doi: 10.1016/S0140-6736(17)31262-X. Epub 2017 May 16. No abstract available.

PMID:
28526492
5.

Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial.

Constable IJ, Lai CM, Magno AL, French MA, Barone SB, Schwartz SD, Blumenkranz MS, Degli-Esposti MA, Rakoczy EP.

Am J Ophthalmol. 2017 May;177:150-158. doi: 10.1016/j.ajo.2017.02.018. Epub 2017 Feb 27.

PMID:
28245970
6.

Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration.

Constable IJ, Pierce CM, Lai CM, Magno AL, Degli-Esposti MA, French MA, McAllister IL, Butler S, Barone SB, Schwartz SD, Blumenkranz MS, Rakoczy EP.

EBioMedicine. 2016 Dec;14:168-175. doi: 10.1016/j.ebiom.2016.11.016. Epub 2016 Nov 10.

7.

Gene Therapy for Age-Related Macular Degeneration.

Constable IJ, Blumenkranz MS, Schwartz SD, Barone S, Lai CM, Rakoczy EP.

Asia Pac J Ophthalmol (Phila). 2016 Jul-Aug;5(4):300-3. doi: 10.1097/APO.0000000000000222.

PMID:
27488071
8.

Biomarkers for Diabetic Retinopathy - Could Endothelin 2 Be Part of the Answer?

Binz N, Rakoczy EP, Ali Rahman IS, Vagaja NN, Lai CM.

PLoS One. 2016 Aug 2;11(8):e0160442. doi: 10.1371/journal.pone.0160442. eCollection 2016.

9.

Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial.

Rakoczy EP, Lai CM, Magno AL, Wikstrom ME, French MA, Pierce CM, Schwartz SD, Blumenkranz MS, Chalberg TW, Degli-Esposti MA, Constable IJ.

Lancet. 2015 Dec 12;386(10011):2395-403. doi: 10.1016/S0140-6736(15)00345-1. Epub 2015 Sep 30.

PMID:
26431823
10.

Angiography reveals novel features of the retinal vasculature in healthy and diabetic mice.

McLenachan S, Magno AL, Ramos D, Catita J, McMenamin PG, Chen FK, Rakoczy EP, Ruberte J.

Exp Eye Res. 2015 Sep;138:6-21. doi: 10.1016/j.exer.2015.06.023. Epub 2015 Jun 26.

PMID:
26122048
11.

Gene therapy for eye as regenerative medicine? Lessons from RPE65 gene therapy for Leber's Congenital Amaurosis.

Rakoczy EP, Narfström K.

Int J Biochem Cell Biol. 2014 Nov;56:153-7. doi: 10.1016/j.biocel.2014.09.022. Epub 2014 Oct 5.

PMID:
25286304
12.

Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy.

Wisniewska-Kruk J, Klaassen I, Vogels IM, Magno AL, Lai CM, Van Noorden CJ, Schlingemann RO, Rakoczy EP.

Exp Eye Res. 2014 May;122:123-31. doi: 10.1016/j.exer.2014.03.005. Epub 2014 Apr 3.

PMID:
24703908
13.

Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa.

McKeone R, Wikstrom M, Kiel C, Rakoczy PE.

Mol Vis. 2014 Feb 7;20:183-99. eCollection 2014.

14.

Influence of endotoxin-mediated retinal inflammation on phenotype of diabetic retinopathy in Ins2 Akita mice.

Vagaja NN, Binz N, McLenachan S, Rakoczy EP, McMenamin PG.

Br J Ophthalmol. 2013 Oct;97(10):1343-50. doi: 10.1136/bjophthalmol-2013-303201. Epub 2013 Aug 2.

15.

Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy.

Mendel TA, Clabough EB, Kao DS, Demidova-Rice TN, Durham JT, Zotter BC, Seaman SA, Cronk SM, Rakoczy EP, Katz AJ, Herman IM, Peirce SM, Yates PA.

PLoS One. 2013 May 31;8(5):e65691. doi: 10.1371/journal.pone.0065691. Print 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/679017bf-abd5-44ce-9e20-5e7af1cd3468.

16.

Absence of clinical correlates of diabetic retinopathy in the Ins2Akita retina.

McLenachan S, Chen X, McMenamin PG, Rakoczy EP.

Clin Exp Ophthalmol. 2013 Aug;41(6):582-92. doi: 10.1111/ceo.12084. Epub 2013 May 21.

PMID:
23433122
17.

The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse.

Kezic JM, Chen X, Rakoczy EP, McMenamin PG.

Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):854-63. doi: 10.1167/iovs.12-10876.

18.

Effect of vascular endothelial growth factor upregulation on retinal gene expression in the Kimba mouse.

Binz N, Ali Rahman IS, Chinnery HR, McKeone R, Simpson KM, Speed TP, Lai CM, Rakoczy PE.

Clin Exp Ophthalmol. 2013 Apr;41(3):251-62. doi: 10.1111/j.1442-9071.2012.02845.x. Epub 2012 Oct 17.

PMID:
22788671
19.

Changes in murine hyalocytes are valuable early indicators of ocular disease.

Vagaja NN, Chinnery HR, Binz N, Kezic JM, Rakoczy EP, McMenamin PG.

Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1445-51. doi: 10.1167/iovs.11-8601.

PMID:
22297487
20.

In vivo monitoring of VEGF-induced retinal damage in the Kimba mouse model of retinal neovascularization.

Ali Rahman IS, Li CR, Lai CM, Rakoczy EP.

Curr Eye Res. 2011 Jul;36(7):654-62. doi: 10.3109/02713683.2010.551172.

PMID:
21657827

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