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Items: 5

1.

Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities.

Lafayette EA, de Almeida SMV, Cavalcanti Santos RV, de Oliveira JF, Amorim CADC, da Silva RMF, Pitta MGDR, Pitta IDR, de Moura RO, de Carvalho Júnior LB, de Melo Rêgo MJB, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:511-522. doi: 10.1016/j.ejmech.2017.05.012. Epub 2017 May 4.

PMID:
28531811
2.

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.

de Oliveira JF, Lima TS, Vendramini-Costa DB, de Lacerda Pedrosa SCB, Lafayette EA, da Silva RMF, de Almeida SMV, de Moura RO, Ruiz ALTG, de Carvalho JE, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:305-314. doi: 10.1016/j.ejmech.2017.05.023. Epub 2017 May 8.

PMID:
28505535
3.

New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases.

Almeida SM, Lafayette EA, Silva WL, Lima Serafim V, Menezes TM, Neves JL, Ruiz AL, Carvalho JE, Moura RO, Beltrão EI, Carvalho Júnior LB, Lima MD.

Int J Biol Macromol. 2016 Nov;92:467-475. doi: 10.1016/j.ijbiomac.2016.07.057. Epub 2016 Jul 18.

PMID:
27435006
4.

Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives.

de Almeida SM, Lafayette EA, da Silva LP, Amorim CA, de Oliveira TB, Ruiz AL, de Carvalho JE, de Moura RO, Beltrão EI, de Lima Mdo C, de Carvalho Júnior LB.

Int J Mol Sci. 2015 Jun 9;16(6):13023-42. doi: 10.3390/ijms160613023.

5.

Synthesis, DNA binding and topoisomerase I inhibition activity of thiazacridine and imidazacridine derivatives.

Lafayette EA, Vitalino de Almeida SM, Pitta MG, Carneiro Beltrão EI, da Silva TG, Olímpio de Moura R, Pitta Ida R, de Carvalho LB Jr, de Lima Mdo C.

Molecules. 2013 Dec 6;18(12):15035-50. doi: 10.3390/molecules181215035.

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