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Items: 1 to 20 of 29

1.

New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole.

Dos Santos Nascimento MVP, Mattar Munhoz AC, De Campos Facchin BM, Fratoni E, Rossa TA, Mandolesi Sá M, Campa CC, Ciraolo E, Hirsch E, Dalmarco EM.

Biomed Pharmacother. 2019 Mar;111:1399-1407. doi: 10.1016/j.biopha.2019.01.052. Epub 2019 Jan 19.

2.

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.

3.

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR.

Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3.

4.

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

Duarte LJ, Chaves VC, Nascimento MVPDS, Calvete E, Li M, Ciraolo E, Ghigo A, Hirsch E, Simões CMO, Reginatto FH, Dalmarco EM.

Food Chem. 2018 May 1;247:56-65. doi: 10.1016/j.foodchem.2017.12.015. Epub 2017 Dec 7.

PMID:
29277228
5.

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

Gulluni F, Martini M, De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Fan F, Meraldi P, Marchiò C, Pece S, Sapino A, Chiarle R, Di Fiore PP, Hirsch E.

Cancer Cell. 2017 Oct 9;32(4):444-459.e7. doi: 10.1016/j.ccell.2017.09.002.

6.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

7.

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E.

Sci Signal. 2016 Dec 20;9(459):ra124. doi: 10.1126/scisignal.aah5882.

PMID:
27999173
8.

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.

Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR.

Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877.

9.

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Galli U, Ciraolo E, Massarotti A, Margaria JP, Sorba G, Hirsch E, Tron GC.

Molecules. 2015 Sep 18;20(9):17275-87. doi: 10.3390/molecules200917275.

10.

Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.

Galluzzo M, Ciraolo E, Lucattelli M, Hoxha E, Ulrich M, Campa CC, Lungarella G, Doring G, Zhou-Suckow Z, Mall M, Hirsch E, De Rose V.

Mediators Inflamm. 2015;2015:545417. doi: 10.1155/2015/545417. Epub 2015 Jun 21.

11.

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E.

Nat Commun. 2015 Jun 23;6:7400. doi: 10.1038/ncomms8400.

12.

Crossroads of PI3K and Rac pathways.

Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E.

Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. Review.

13.

Methods to measure the enzymatic activity of PI3Ks.

Ciraolo E, Gulluni F, Hirsch E.

Methods Enzymol. 2014;543:115-40. doi: 10.1016/B978-0-12-801329-8.00006-4.

PMID:
24924130
14.

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.

Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E.

Dev Cell. 2014 Mar 31;28(6):647-58. doi: 10.1016/j.devcel.2014.01.022.

15.

Targeting PI3K in Cancer: Any Good News?

Martini M, Ciraolo E, Gulluni F, Hirsch E.

Front Oncol. 2013 May 8;3:108. doi: 10.3389/fonc.2013.00108. eCollection 2013.

16.

Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.

Consonni A, Cipolla L, Guidetti G, Canobbio I, Ciraolo E, Hirsch E, Falasca M, Okigaki M, Balduini C, Torti M.

Blood. 2012 Jan 19;119(3):847-56. doi: 10.1182/blood-2011-07-364992. Epub 2011 Nov 21.

PMID:
22106345
17.

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.

Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, Landolfi A, Selvetella G, Grieco P, Damato A, Franco E, Haase H, Maffei A, Ciraolo E, Fucile S, Frati G, Mazzoni O, Hirsch E, Lembo G.

Cardiovasc Res. 2012 Jan 1;93(1):200-9. doi: 10.1093/cvr/cvr288. Epub 2011 Oct 27.

PMID:
22038741
18.

Measuring PI3K lipid kinase activity.

Ciraolo E, Perino A, Hirsch E.

Methods Mol Biol. 2012;795:55-67. doi: 10.1007/978-1-61779-337-0_4.

PMID:
21960215
19.

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

Guasconi M, Lu X, Massarotti A, Caldarelli A, Ciraolo E, Tron GC, Hirsch E, Sorba G, Pirali T.

Org Biomol Chem. 2011 Jun 7;9(11):4144-9. doi: 10.1039/c1ob05336a. Epub 2011 Apr 14.

PMID:
21494711
20.

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines.

Lu XY, Ciraolo E, Stefenia R, Chen GQ, Zhang Y, Hirsch E.

Appl Microbiol Biotechnol. 2011 Mar;89(5):1423-33. doi: 10.1007/s00253-011-3101-1. Epub 2011 Feb 1.

PMID:
21286711

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