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Mar Drugs. 2018 Jan 1;16(1). pii: E6. doi: 10.3390/md16010006.

Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products.

Author information

1
Department of Pharmaceutical Sciences, Medicinal Chemistry Section, Pharmacy Faculty, CIETUS, IBSAL, University of Salamanca, E-37007 Salamanca, Spain. pabloagg@usal.es.
2
Department of Pharmaceutical Sciences, Medicinal Chemistry Section, Pharmacy Faculty, CIETUS, IBSAL, University of Salamanca, E-37007 Salamanca, Spain. elenitavm@usal.es.
3
Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, E-37008 Salamanca, Spain. ddm@usal.es.
4
Department of Pharmaceutical Sciences, Medicinal Chemistry Section, Pharmacy Faculty, CIETUS, IBSAL, University of Salamanca, E-37007 Salamanca, Spain. macg@usal.es.

Abstract

Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and biological properties are considered together with synthetic approaches towards the natural products and bioactive analogues. This review contributes to studies of structure-activity relationships for these metabolites and highlights the potential of the sea as a source of new lead compounds in diverse therapeutic fields.

KEYWORDS:

alkylpurines; antimicrobial activity; cytotoxicity; marine natural products; methylpurines; purines; terpenylpurines

PMID:
29301246
PMCID:
PMC5793054
DOI:
10.3390/md16010006
[Indexed for MEDLINE]
Free PMC Article

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