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Items: 18


Ring Finger Protein 11 (RNF11) acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.

Mattioni A, Boldt K, Auciello G, Komada M, Rappoport JZ, Ueffing M, Castagnoli L, Cesareni G, Santonico E.

FEBS J. 2020 Jan 27. doi: 10.1111/febs.15226. [Epub ahead of print]


Erratum: Nepravishta, R., et al. CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1. Biomolecules 2019, 9, 284.

Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E.

Biomolecules. 2019 Nov 28;9(12). pii: E803. doi: 10.3390/biom9120803.


CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1.

Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E.

Biomolecules. 2019 Jul 17;9(7). pii: E284. doi: 10.3390/biom9070284. Erratum in: Biomolecules. 2019 Nov 28;9(12):.


CUBAN, a Case Study of Selective Binding: Structural Details of the Discrimination between Ubiquitin and NEDD8.

Santonico E, Nepravishta R, Mandaliti W, Castagnoli L, Cesareni G, Paci M.

Int J Mol Sci. 2019 Mar 8;20(5). pii: E1185. doi: 10.3390/ijms20051185.


Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8.

Castagnoli L, Mandaliti W, Nepravishta R, Valentini E, Mattioni A, Procopio R, Iannuccelli M, Polo S, Paci M, Cesareni G, Santonico E.

FEBS J. 2019 Feb;286(4):653-677. doi: 10.1111/febs.14752. Epub 2019 Feb 5.


Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases.

Palma A, Tinti M, Paoluzi S, Santonico E, Brandt BW, Hooft van Huijsduijnen R, Masch A, Heringa J, Schutkowski M, Castagnoli L, Cesareni G.

J Biol Chem. 2017 Mar 24;292(12):4942-4952. doi: 10.1074/jbc.M116.757518. Epub 2017 Feb 3.


A subset of RAB proteins modulates PP2A phosphatase activity.

Sacco F, Mattioni A, Boldt K, Panni S, Santonico E, Castagnoli L, Ueffing M, Cesareni G.

Sci Rep. 2016 Sep 9;6:32857. doi: 10.1038/srep32857.


SIGNOR: a database of causal relationships between biological entities.

Perfetto L, Briganti L, Calderone A, Cerquone Perpetuini A, Iannuccelli M, Langone F, Licata L, Marinkovic M, Mattioni A, Pavlidou T, Peluso D, Petrilli LL, PirrĂ² S, Posca D, Santonico E, Silvestri A, Spada F, Castagnoli L, Cesareni G.

Nucleic Acids Res. 2016 Jan 4;44(D1):D548-54. doi: 10.1093/nar/gkv1048. Epub 2015 Oct 13.


The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R.

Panni S, Salvioli S, Santonico E, Langone F, Storino F, Altilia S, Franceschi C, Cesareni G, Castagnoli L.

J Biochem. 2015 Feb;157(2):101-11. doi: 10.1093/jb/mvu059. Epub 2014 Sep 26.


HuPho: the human phosphatase portal.

Liberti S, Sacco F, Calderone A, Perfetto L, Iannuccelli M, Panni S, Santonico E, Palma A, Nardozza AP, Castagnoli L, Cesareni G.

FEBS J. 2013 Jan;280(2):379-87. doi: 10.1111/j.1742-4658.2012.08712.x. Epub 2012 Aug 24.


MINT, the molecular interaction database: 2012 update.

Licata L, Briganti L, Peluso D, Perfetto L, Iannuccelli M, Galeota E, Sacco F, Palma A, Nardozza AP, Santonico E, Castagnoli L, Cesareni G.

Nucleic Acids Res. 2012 Jan;40(Database issue):D857-61. doi: 10.1093/nar/gkr930. Epub 2011 Nov 16.


Combining peptide recognition specificity and context information for the prediction of the 14-3-3-mediated interactome in S. cerevisiae and H. sapiens.

Panni S, Montecchi-Palazzi L, Kiemer L, Cabibbo A, Paoluzi S, Santonico E, Landgraf C, Volkmer-Engert R, Bachi A, Castagnoli L, Cesareni G.

Proteomics. 2011 Jan;11(1):128-43. doi: 10.1002/pmic.201000030. Epub 2010 Dec 6.


The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.

Tomassi L, Costantini A, Corallino S, Santonico E, Carducci M, Cesareni G, Castagnoli L.

BMC Biochem. 2008 Jul 22;9:21. doi: 10.1186/1471-2091-9-21.


Binding to DPF-motif by the POB1 EH domain is responsible for POB1-Eps15 interaction.

Santonico E, Panni S, Falconi M, Castagnoli L, Cesareni G.

BMC Biochem. 2007 Dec 21;8:29.


DOMINO: a database of domain-peptide interactions.

Ceol A, Chatr-aryamontri A, Santonico E, Sacco R, Castagnoli L, Cesareni G.

Nucleic Acids Res. 2007 Jan;35(Database issue):D557-60. Epub 2006 Nov 29.


Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.

Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, Marmor MD, Kochupurakkal BS, Katz M, Lavi S, Cesareni G, Yarden Y.

J Biol Chem. 2006 Aug 4;281(31):21640-51. Epub 2006 May 30.


Methods to reveal domain networks.

Santonico E, Castagnoli L, Cesareni G.

Drug Discov Today. 2005 Aug 15;10(16):1111-7. Review.


Selectivity and promiscuity in the interaction network mediated by protein recognition modules.

Castagnoli L, Costantini A, Dall'Armi C, Gonfloni S, Montecchi-Palazzi L, Panni S, Paoluzi S, Santonico E, Cesareni G.

FEBS Lett. 2004 Jun 1;567(1):74-9. Review.

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