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Items: 18

1.

Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.

Sánchez-Fernández EM, García-Moreno MI, Arroba AI, Aguilar-Diosdado M, Padrón JM, García-Hernández R, Gamarro F, Fustero S, Sánchez-Aparicio JE, Masgrau L, García Fernández JM, Ortiz Mellet C.

Eur J Med Chem. 2019 Aug 8;182:111604. doi: 10.1016/j.ejmech.2019.111604. [Epub ahead of print]

PMID:
31425910
2.

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids.

Sánchez-Fernández EM, García-Moreno MI, García-Hernández R, Padrón JM, García Fernández JM, Gamarro F, Ortiz Mellet C.

Molecules. 2019 Aug 8;24(16). pii: E2882. doi: 10.3390/molecules24162882.

3.

sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo.

Schaeffer E, Sánchez-Fernández EM, Gonçalves-Pereira R, Flacher V, Lamon D, Duval M, Fauny JD, García Fernández JM, Mueller CG, Ortiz Mellet C.

Eur J Med Chem. 2019 May 1;169:111-120. doi: 10.1016/j.ejmech.2019.02.078. Epub 2019 Mar 5.

PMID:
30870792
4.

The sp2-iminosugar glycolipid 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants.

Alcalde-Estévez E, Arroba AI, Sánchez-Fernández EM, Mellet CO, García Fernández JM, Masgrau L, Valverde ÁM.

Food Chem Toxicol. 2018 Jan;111:454-466. doi: 10.1016/j.fct.2017.11.050. Epub 2017 Nov 27.

PMID:
29191728
5.

Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.

García-Moreno MI, de la Mata M, Sánchez-Fernández EM, Benito JM, Díaz-Quintana A, Fustero S, Nanba E, Higaki K, Sánchez-Alcázar JA, García Fernández JM, Ortiz Mellet C.

J Med Chem. 2017 Mar 9;60(5):1829-1842. doi: 10.1021/acs.jmedchem.6b01550. Epub 2017 Feb 22.

PMID:
28171725
6.

sp2 -Iminosugar α-glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways.

Gueder N, Allan G, Telliez MS, Hague F, Fernandez JM, Sanchez-Fernandez EM, Ortiz-Mellet C, Ahidouch A, Ouadid-Ahidouch H.

J Cell Physiol. 2017 Dec;232(12):3631-3640. doi: 10.1002/jcp.25832. Epub 2017 Apr 25.

PMID:
28145580
7.

Correction to "Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics".

Sánchez-Fernández EM, Rísquez-Cuadro R, Aguilar-Moncayo M, García-Moreno MI, Ortiz Mellet C, García Fernández JM.

Org Lett. 2016 Oct 7;18(19):5188. Epub 2016 Sep 14. No abstract available.

PMID:
27627670
8.

Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody.

Fernández EM, Navo CD, Martínez-Sáez N, Gonçalves-Pereira R, Somovilla VJ, Avenoza A, Busto JH, Bernardes GJ, Jiménez-Osés G, Corzana F, Fernández JM, Mellet CO, Peregrina JM.

Org Lett. 2016 Aug 5;18(15):3890-3. doi: 10.1021/acs.orglett.6b01899. Epub 2016 Jul 25.

PMID:
27453399
9.

Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice.

Arroba AI, Alcalde-Estevez E, García-Ramírez M, Cazzoni D, de la Villa P, Sánchez-Fernández EM, Mellet CO, García Fernández JM, Hernández C, Simó R, Valverde ÁM.

Biochim Biophys Acta. 2016 Sep;1862(9):1663-74. doi: 10.1016/j.bbadis.2016.05.024. Epub 2016 Jun 4. No abstract available.

10.

Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases.

Sánchez-Fernández EM, García Fernández JM, Mellet CO.

Chem Commun (Camb). 2016 Apr 25;52(32):5497-515. doi: 10.1039/c6cc01564f.

PMID:
27043200
11.

Influence of the configurational pattern of sp(2)-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties.

Sánchez-Fernández EM, Gonçalves-Pereira R, Rísquez-Cuadro R, Plata GB, Padrón JM, García Fernández JM, Ortiz Mellet C.

Carbohydr Res. 2016 Jun 24;429:113-22. doi: 10.1016/j.carres.2016.01.006. Epub 2016 Jan 21.

PMID:
26850915
12.

Synthesis of multibranched australine derivatives from reducing castanospermine analogues through the Amadori rearrangement of gem-diamine intermediates: selective inhibitors of β-glucosidase.

Sánchez-Fernández EM, Álvarez E, Ortiz Mellet C, García Fernández JM.

J Org Chem. 2014 Dec 5;79(23):11722-8. doi: 10.1021/jo5025283. Epub 2014 Nov 20.

PMID:
25390345
13.

New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells.

Allan G, Ouadid-Ahidouch H, Sanchez-Fernandez EM, Risquez-Cuadro R, Fernandez JM, Ortiz-Mellet C, Ahidouch A.

PLoS One. 2013 Oct 4;8(10):e76411. doi: 10.1371/journal.pone.0076411. eCollection 2013.

14.

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.

Sánchez-Fernández EM, Tarhonskaya H, Al-Qahtani K, Hopkinson RJ, McCullagh JS, Schofield CJ, Flashman E.

Biochem J. 2013 Jan 15;449(2):491-6. doi: 10.1042/BJ20121155.

15.

sp2-Iminosugar O-, S-, and N-glycosides as conformational mimics of α-linked disaccharides; implications for glycosidase inhibition.

Sánchez-Fernández EM, Rísquez-Cuadro R, Ortiz Mellet C, García Fernández JM, Nieto PM, Angulo J.

Chemistry. 2012 Jul 2;18(27):8527-39. doi: 10.1002/chem.201200279. Epub 2012 Jun 4.

PMID:
22674827
16.

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.

Sánchez-Fernández EM, Rísquez-Cuadro R, Chasseraud M, Ahidouch A, Ortiz Mellet C, Ouadid-Ahidouch H, García Fernández JM.

Chem Commun (Camb). 2010 Aug 7;46(29):5328-30. doi: 10.1039/c0cc00446d. Epub 2010 Jun 15.

PMID:
20552113
17.

Generalized anomeric effect in gem-diamines: stereoselective synthesis of alpha-N-linked disaccharide mimics.

Sánchez-Fernández EM, Rísquez-Cuadro R, Aguilar-Moncayo M, García-Moreno MI, Ortiz Mellet C, García Fernández JM.

Org Lett. 2009 Aug 6;11(15):3306-9. doi: 10.1021/ol901125n. Erratum in: Org Lett. 2016 Oct 7;18(19):5188.

PMID:
19606851
18.

Asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition.

Abraham E, Brock EA, Candela-Lena JI, Davies SG, Georgiou M, Nicholson RL, Perkins JH, Roberts PM, Russell AJ, Sánchez-Fernández EM, Scott PM, Smith AD, Thomson JE.

Org Biomol Chem. 2008 May 7;6(9):1665-73. doi: 10.1039/b801671b. Epub 2008 Mar 19.

PMID:
18421401

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