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Items: 1 to 20 of 347

1.

Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child.

Wijeyesekera A, Wagner J, De Goffau M, Thurston S, Rodrigues Sabino A, Zaher S, White D, Ridout J, Peters MJ, Ramnarayan P, Branco RG, Torok ME, Valla F, Meyer R, Klein N, Frost G, Parkhill J, Holmes E, Pathan N.

Crit Care Med. 2019 Jun 4. doi: 10.1097/CCM.0000000000003841. [Epub ahead of print]

PMID:
31169619
2.

Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function.

Alkandari A, Ashrafian H, Sathyapalan T, Darzi A, Holmes E, Athanasiou T, Atkin SL, Gooderham NJ.

Front Endocrinol (Lausanne). 2019 May 21;10:319. doi: 10.3389/fendo.2019.00319. eCollection 2019.

3.

Characterization of the urinary metabolic profile of cholangiocarcinoma in a United Kingdom population.

Alsaleh M, Barbera TA, Reeves HL, Cramp ME, Ryder S, Gabra H, Nash K, Shen YL, Holmes E, Williams R, Taylor-Robinson SD.

Hepat Med. 2019 May 3;11:47-67. doi: 10.2147/HMER.S193996. eCollection 2019.

4.

Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease.

Tzoulaki I, Castagné R, Boulangé CL, Karaman I, Chekmeneva E, Evangelou E, Ebbels TMD, Kaluarachchi MR, Chadeau-Hyam M, Mosen D, Dehghan A, Moayyeri A, Ferreira DLS, Guo X, Rotter JI, Taylor KD, Kavousi M, de Vries PS, Lehne B, Loh M, Hofman A, Nicholson JK, Chambers J, Gieger C, Holmes E, Tracy R, Kooner J, Greenland P, Franco OH, Herrington D, Lindon JC, Elliott P.

Eur Heart J. 2019 May 18. pii: ehz235. doi: 10.1093/eurheartj/ehz235. [Epub ahead of print]

5.

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Byrne CS, Chambers ES, Preston T, Tedford C, Brignardello J, Garcia-Perez I, Holmes E, Wallis GA, Morrison DJ, Frost GS.

Nutrients. 2019 Apr 16;11(4). pii: E861. doi: 10.3390/nu11040861.

6.

Enhanced Microbial Bile Acid Deconjugation and Impaired Ileal Uptake in Pregnancy Repress Intestinal Regulation of Bile Acid Synthesis.

Ovadia C, Perdones-Montero A, Spagou K, Smith A, Sarafian MH, Gomez-Romero M, Bellafante E, Clarke LCD, Sadiq F, Nikolova V, Mitchell A, Dixon PH, Santa-Pinter N, Wahlström A, Abu-Hayyeh S, Walters JRF, Marschall HU, Holmes E, Marchesi JR, Williamson C.

Hepatology. 2019 Apr 15. doi: 10.1002/hep.30661. [Epub ahead of print]

PMID:
30983011
7.

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS.

Gut. 2019 Apr 10. pii: gutjnl-2019-318424. doi: 10.1136/gutjnl-2019-318424. [Epub ahead of print]

8.

Obesity and Cage Environment Modulate Metabolism in the Zucker Rat: A Multiple Biological Matrix Approach to Characterizing Metabolic Phenomena.

Lees HJ, Swann JR, Poucher S, Holmes E, Wilson ID, Nicholson JK.

J Proteome Res. 2019 May 3;18(5):2160-2174. doi: 10.1021/acs.jproteome.9b00040. Epub 2019 Apr 18.

PMID:
30939873
9.

Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.

Whiley L, Nye LC, Grant I, Andreas N, Chappell KE, Sarafian MH, Misra R, Plumb RS, Lewis MR, Nicholson JK, Holmes E, Swann JR, Wilson ID.

Anal Chem. 2019 Apr 16;91(8):5207-5216. doi: 10.1021/acs.analchem.8b05884. Epub 2019 Mar 25.

10.

Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection.

Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR.

Gut. 2019 Feb 11. pii: gutjnl-2018-317842. doi: 10.1136/gutjnl-2018-317842. [Epub ahead of print]

11.

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus.

Hegade VS, Pechlivanis A, McDonald JAK, Rees D, Corrigan M, Hirschfield GM, Taylor-Robinson SD, Holmes E, Marchesi JR, Kendrick S, Jones DE.

Liver Int. 2019 May;39(5):967-975. doi: 10.1111/liv.14069. Epub 2019 Feb 25.

PMID:
30735608
12.

NMR and MS urinary metabolic phenotyping in kidney diseases is fit-for-purpose in the presence of a protease inhibitor.

Boulangé CL, Rood IM, Posma JM, Lindon JC, Holmes E, Wetzels JFM, Deegens JKJ, Kaluarachchi MR.

Mol Omics. 2019 Feb 11;15(1):39-49. doi: 10.1039/c8mo00190a.

PMID:
30672550
13.

The metabolic fate and effects of 2-Bromophenol in male Sprague-Dawley rats.

Adesina-Georgiadis KN, Gray N, Plumb RS, Thompson DF, Holmes E, Nicholson JK, Wilson ID.

Xenobiotica. 2018 Dec 17:1-8. doi: 10.1080/00498254.2018.1559376. [Epub ahead of print]

PMID:
30557119
14.

Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial.

Walsh K, Calder N, Olupot-Olupot P, Ssenyondo T, Okiror W, Okalebo CB, Muhindo R, Mpoya A, Holmes E, Marchesi J, Delamare de la Villenaise de Chenevarin G, Frost G, Maitland K.

Wellcome Open Res. 2018 Aug 2;3:95. doi: 10.12688/wellcomeopenres.14706.1. eCollection 2018.

15.

Profiling inflammatory markers in patients with pneumonia on intensive care.

Antcliffe DB, Wolfer AM, O'Dea KP, Takata M, Holmes E, Gordon AC.

Sci Rep. 2018 Oct 3;8(1):14736. doi: 10.1038/s41598-018-32938-6.

16.

Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by 1H NMR Spectroscopy in a Multilaboratory Trial.

Jiménez B, Holmes E, Heude C, Tolson RF, Harvey N, Lodge SL, Chetwynd AJ, Cannet C, Fang F, Pearce JTM, Lewis MR, Viant MR, Lindon JC, Spraul M, Schäfer H, Nicholson JK.

Anal Chem. 2018 Oct 16;90(20):11962-11971. doi: 10.1021/acs.analchem.8b02412. Epub 2018 Sep 27.

PMID:
30211542
17.

Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Direct Infusion-High-Resolution Mass Spectrometry for Combined Exploratory and Targeted Metabolic Profiling of Human Urine.

Chekmeneva E, Dos Santos Correia G, Gómez-Romero M, Stamler J, Chan Q, Elliott P, Nicholson JK, Holmes E.

J Proteome Res. 2018 Oct 5;17(10):3492-3502. doi: 10.1021/acs.jproteome.8b00413. Epub 2018 Sep 19.

18.

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism.

Liu Z, Xia B, Saric J, Utzinger J, Holmes E, Keiser J, Li JV.

J Proteome Res. 2018 Oct 5;17(10):3565-3573. doi: 10.1021/acs.jproteome.8b00583. Epub 2018 Sep 20.

PMID:
30183313
19.

Publisher Correction: Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.

Hoyles L, Fernández-Real JM, Federici M, Serino M, Abbott J, Charpentier J, Heymes C, Luque JL, Anthony E, Barton RH, Chilloux J, Myridakis A, Martinez-Gili L, Moreno-Navarrete JM, Benhamed F, Azalbert V, Blasco-Baque V, Puig J, Xifra G, Ricart W, Tomlinson C, Woodbridge M, Cardellini M, Davato F, Cardolini I, Porzio O, Gentileschi P, Lopez F, Foufelle F, Butcher SA, Holmes E, Nicholson JK, Postic C, Burcelin R, Dumas ME.

Nat Med. 2018 Oct;24(10):1628. doi: 10.1038/s41591-018-0169-5.

PMID:
30093731
20.

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota.

McDonald JAK, Mullish BH, Pechlivanis A, Liu Z, Brignardello J, Kao D, Holmes E, Li JV, Clarke TB, Thursz MR, Marchesi JR.

Gastroenterology. 2018 Nov;155(5):1495-1507.e15. doi: 10.1053/j.gastro.2018.07.014. Epub 2018 Jul 17.

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