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Discovery of a Highly Selective MC1R Agonists Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging Properties.

Jackson E, Heidl M, Imfeld D, Meeus L, Schuetz R, Campiche R.

Int J Mol Sci. 2019 Dec 5;20(24). pii: E6143. doi: 10.3390/ijms20246143.


A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.

Borsari C, Rageot D, Dall'Asen A, Bohnacker T, Melone A, Sele AM, Jackson E, Langlois JB, Beaufils F, Hebeisen P, Fabbro D, Hillmann P, Wymann MP.

J Med Chem. 2019 Sep 26;62(18):8609-8630. doi: 10.1021/acs.jmedchem.9b00972. Epub 2019 Sep 11.


Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1.

Boudon S, Heidl M, Vuorinen A, Wandeler E, Campiche R, Odermatt A, Jackson E.

Bioorg Med Chem. 2018 Oct 1;26(18):5128-5139. doi: 10.1016/j.bmc.2018.09.009. Epub 2018 Sep 12.


5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.

Beaufils F, Cmiljanovic N, Cmiljanovic V, Bohnacker T, Melone A, Marone R, Jackson E, Zhang X, Sele A, Borsari C, Mestan J, Hebeisen P, Hillmann P, Giese B, Zvelebil M, Fabbro D, Williams RL, Rageot D, Wymann MP.

J Med Chem. 2017 Sep 14;60(17):7524-7538. doi: 10.1021/acs.jmedchem.7b00930. Epub 2017 Sep 1.


Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV.

Boudon SM, Vuorinen A, Geotti-Bianchini P, Wandeler E, Kratschmar DV, Heidl M, Campiche R, Jackson E, Odermatt A.

PLoS One. 2017 Feb 2;12(2):e0171079. doi: 10.1371/journal.pone.0171079. eCollection 2017.

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