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Items: 1 to 20 of 58


A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation.

Martínez-Burgo B, Cobb SL, Pohl E, Kashanin D, Paul T, Kirby JA, Sheerin NS, Ali S.

Immunology. 2019 Jun;157(2):173-184. doi: 10.1111/imm.13063.


Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds.

Tatum NJ, Duarte F, Kamerlin SCL, Pohl E.

J Phys Chem Lett. 2019 May 2;10(9):2244-2249. doi: 10.1021/acs.jpclett.9b00741. Epub 2019 Apr 23.


A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii.

Melatti C, Pieperhoff M, Lemgruber L, Pohl E, Sheiner L, Meissner M.

PLoS Pathog. 2019 Apr 4;15(4):e1007512. doi: 10.1371/journal.ppat.1007512. eCollection 2019 Apr.


How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project.

Bruce D, Cardew E, Freitag-Pohl S, Pohl E.

J Vis Exp. 2019 Feb 11;(144). doi: 10.3791/58666.


Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways.

Chisholm DR, Tomlinson CWE, Zhou GL, Holden C, Affleck V, Lamb R, Newling K, Ashton P, Valentine R, Redfern C, Erostyák J, Makkai G, Ambler CA, Whiting A, Pohl E.

ACS Chem Biol. 2019 Mar 15;14(3):369-377. doi: 10.1021/acschembio.8b00916. Epub 2019 Feb 13.


Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins.

Tomlinson CWE, Chisholm DR, Valentine R, Whiting A, Pohl E.

ACS Med Chem Lett. 2018 Nov 9;9(12):1297-1300. doi: 10.1021/acsmedchemlett.8b00420. eCollection 2018 Dec 13.


Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii.

Mbekeani AJ, Stanley WA, Kalel VC, Dahan N, Zalckvar E, Sheiner L, Schliebs W, Erdmann R, Pohl E, Denny PW.

Genes (Basel). 2018 Aug 29;9(9). pii: E434. doi: 10.3390/genes9090434.


Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.

Haffez H, Chisholm DR, Tatum NJ, Valentine R, Redfern C, Pohl E, Whiting A, Przyborski S.

Bioorg Med Chem. 2018 May 1;26(8):1560-1572. doi: 10.1016/j.bmc.2018.02.002. Epub 2018 Feb 10.


The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.

Cardew EM, Verlinde CLMJ, Pohl E.

Parasitology. 2018 Feb;145(2):210-218. doi: 10.1017/S0031182017001901. Epub 2017 Dec 1. Review.


New active leads for tuberculosis booster drugs by structure-based drug discovery.

Tatum NJ, Liebeschuetz JW, Cole JC, Frita R, Herledan A, Baulard AR, Willand N, Pohl E.

Org Biomol Chem. 2017 Dec 13;15(48):10245-10255. doi: 10.1039/c7ob00910k.


Air/Liquid Interfacial Nanoassembly of Molecular Building Blocks into Preferentially Oriented Porous Organic Nanosheet Crystals via Hydrogen Bonding.

Makiura R, Tsuchiyama K, Pohl E, Prassides K, Sakata O, Tajiri H, Konovalov O.

ACS Nano. 2017 Nov 28;11(11):10875-10882. doi: 10.1021/acsnano.7b04447. Epub 2017 Oct 24.


Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites.

Mina JG, Thye JK, Alqaisi AQI, Bird LE, Dods RH, Grøftehauge MK, Mosely JA, Pratt S, Shams-Eldin H, Schwarz RT, Pohl E, Denny PW.

J Biol Chem. 2017 Jul 21;292(29):12208-12219. doi: 10.1074/jbc.M117.792374. Epub 2017 Jun 2.


A tight tunable range for Ni(II) sensing and buffering in cells.

Foster AW, Pernil R, Patterson CJ, Scott AJP, Pålsson LO, Pal R, Cummins I, Chivers PT, Pohl E, Robinson NJ.

Nat Chem Biol. 2017 Apr;13(4):409-414. doi: 10.1038/nchembio.2310. Epub 2017 Feb 6.


Mutantelec: An In Silico mutation simulation platform for comparative electrostatic potential profiling of proteins.

Valdebenito-Maturana B, Reyes-Suarez JA, Henriquez J, Holmes DS, Quatrini R, Pohl E, Arenas-Salinas M.

J Comput Chem. 2017 Mar 15;38(7):467-474. doi: 10.1002/jcc.24712.


The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors.

Haffez H, Chisholm DR, Valentine R, Pohl E, Redfern C, Whiting A.

Medchemcomm. 2017 Jan 20;8(3):578-592. doi: 10.1039/c6md00680a. eCollection 2017 Mar 1.


Practical synthetic strategies towards lipophilic 6-iodotetrahydroquinolines and -dihydroquinolines.

Chisholm DR, Zhou GL, Pohl E, Valentine R, Whiting A.

Beilstein J Org Chem. 2016 Aug 16;12:1851-1862. eCollection 2016.


The Effectors and Sensory Sites of Formaldehyde-responsive Regulator FrmR and Metal-sensing Variant.

Osman D, Piergentili C, Chen J, Sayer LN, Usón I, Huggins TG, Robinson NJ, Pohl E.

J Biol Chem. 2016 Sep 9;291(37):19502-16. doi: 10.1074/jbc.M116.745174. Epub 2016 Jul 29.


Conjugate Addition of 3-Buytn-2-one to Anilines in Ethanol: Alkene Geometric Insights through In Situ FTIR Monitoring.

Chisholm DR, Valentine R, Pohl E, Whiting A.

J Org Chem. 2016 Sep 2;81(17):7557-65. doi: 10.1021/acs.joc.6b01110. Epub 2016 Aug 10.


The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein.

Townsend PD, Rodgers TL, Glover LC, Korhonen HJ, Richards SA, Colwell LJ, Pohl E, Wilson MR, Hodgson DR, McLeish TC, Cann MJ.

J Biol Chem. 2015 Sep 4;290(36):22225-35. doi: 10.1074/jbc.M115.669267. Epub 2015 Jul 16.


Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct.

Grøftehauge MK, Truan D, Vasil A, Denny PW, Vasil ML, Pohl E.

Int J Mol Sci. 2015 Jul 14;16(7):15971-84. doi: 10.3390/ijms160715971.

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