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Pharmaceutics. 2018 Nov 8;10(4). pii: E221. doi: 10.3390/pharmaceutics10040221.

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs.

Wong AL1,2, Xiang X3, Ong PS4, Mitchell EQY5, Syn N6,7, Wee I8,9, Kumar AP10,11, Yong WP12,13, Sethi G14, Goh BC15,16,17, Ho PC18, Wang L19,20.

Author information

1
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. andrea_la_wong@nuhs.edu.sg.
2
Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore. andrea_la_wong@nuhs.edu.sg.
3
School of Pharmacy, Fudan University, Shanghai 201203, China. xiangxq@fudan.edu.cn.
4
Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore. phaops@nus.edu.sg.
5
Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore. mitchell.ee.q.y@sgh.com.sg.
6
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. nicholassyn@gmail.com.
7
Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore. nicholassyn@gmail.com.
8
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. ianwee180894@outlook.com.
9
Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore. ianwee180894@outlook.com.
10
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. csiapk@nus.edu.sg.
11
Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore 117597, Singapore. csiapk@nus.edu.sg.
12
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. wei_peng_yong@nuhs.edu.sg.
13
Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore. wei_peng_yong@nuhs.edu.sg.
14
Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore 117597, Singapore. phcgs@nus.edu.sg.
15
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. phcgbc@nus.edu.sg.
16
Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore. phcgbc@nus.edu.sg.
17
Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore 117597, Singapore. phcgbc@nus.edu.sg.
18
Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore. phahocl@nus.edu.sg.
19
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. csiwl@nus.edu.sg.
20
Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore 117597, Singapore. csiwl@nus.edu.sg.

Abstract

In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation.

KEYWORDS:

LC-MS/MS; oncology drugs; quantification; rapid

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