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CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.

Flores-Toro JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Singh R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1129-1138. doi: 10.1073/pnas.1910856117. Epub 2019 Dec 26.


Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging.

Grippin AJ, Wummer B, Wildes T, Dyson K, Trivedi V, Yang C, Sebastian M, Mendez-Gomez HR, Padala S, Grubb M, Fillingim M, Monsalve A, Sayour EJ, Dobson J, Mitchell DA.

ACS Nano. 2019 Dec 24;13(12):13884-13898. doi: 10.1021/acsnano.9b05037. Epub 2019 Dec 2.


Dysregulation of glutamate transport enhances Treg function that promotes VEGF blockade resistance in glioblastoma.

Long Y, Tao H, Karachi A, Grippin AJ, Jin L, Chang YE, Zhang W, Dyson KA, Hou AY, Na M, Deleyrolle LP, Sayour EJ, Rahman M, Mitchell DA, Lin Z, Huang J.

Cancer Res. 2019 Nov 13. pii: canres.1577.2019. doi: 10.1158/0008-5472.CAN-19-1577. [Epub ahead of print]


CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors.

Jin L, Tao H, Karachi A, Long Y, Hou AY, Na M, Dyson KA, Grippin AJ, Deleyrolle LP, Zhang W, Rajon DA, Wang QJ, Yang JC, Kresak JL, Sayour EJ, Rahman M, Bova FJ, Lin Z, Mitchell DA, Huang J.

Nat Commun. 2019 Sep 5;10(1):4016. doi: 10.1038/s41467-019-11869-4.


Emerging trends in immunotherapy for pediatric sarcomas.

Dyson KA, Stover BD, Grippin A, Mendez-Gomez HR, Lagmay J, Mitchell DA, Sayour EJ.

J Hematol Oncol. 2019 Jul 16;12(1):78. doi: 10.1186/s13045-019-0756-z. Review.


Quantitative characterization of 3D bioprinted structural elements under cell generated forces.

Morley CD, Ellison ST, Bhattacharjee T, O'Bryan CS, Zhang Y, Smith KF, Kabb CP, Sebastian M, Moore GL, Schulze KD, Niemi S, Sawyer WG, Tran DD, Mitchell DA, Sumerlin BS, Flores CT, Angelini TE.

Nat Commun. 2019 Jul 10;10(1):3029. doi: 10.1038/s41467-019-10919-1.


Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition.

Karachi A, Yang C, Dastmalchi F, Sayour EJ, Huang J, Azari H, Long Y, Flores C, Mitchell DA, Rahman M.

Neuro Oncol. 2019 Jun 10;21(6):730-741. doi: 10.1093/neuonc/noz015.


RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors.

Pohl-GuimarĂ£es F, Yang C, Dyson KA, Wildes TJ, Drake J, Huang J, Flores C, Sayour EJ, Mitchell DA.

Mol Ther. 2019 Apr 10;27(4):837-849. doi: 10.1016/j.ymthe.2018.10.007. Epub 2018 Oct 17.


Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells.

Wildes TJ, Flores CT, Mitchell DA.

Stem Cells. 2019 Feb;37(2):166-175. doi: 10.1002/stem.2933. Epub 2018 Nov 12. Review.


Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.

Flores CT, Wildes TJ, Drake JA, Moore GL, Dean BD, Abraham RS, Mitchell DA.

Nat Commun. 2018 Oct 17;9(1):4313. doi: 10.1038/s41467-018-06182-5.


Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma.

Hoang-Minh LB, Siebzehnrubl FA, Yang C, Suzuki-Hatano S, Dajac K, Loche T, Andrews N, Schmoll Massari M, Patel J, Amin K, Vuong A, Jimenez-Pascual A, Kubilis P, Garrett TJ, Moneypenny C, Pacak CA, Huang J, Sayour EJ, Mitchell DA, Sarkisian MR, Reynolds BA, Deleyrolle LP.

EMBO J. 2018 Dec 3;37(23). pii: e98772. doi: 10.15252/embj.201798772. Epub 2018 Oct 15.


Immunotherapy for Brain Tumors.

Hoang-Minh LB, Mitchell DA.

Curr Treat Options Oncol. 2018 Oct 11;19(11):60. doi: 10.1007/s11864-018-0576-3. Review.


Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy.

Sayour EJ, Grippin A, De Leon G, Stover B, Rahman M, Karachi A, Wummer B, Moore G, Castillo-Caro P, Fredenburg K, Sarkisian MR, Huang J, Deleyrolle LP, Sahay B, Carrera-Justiz S, Mendez-Gomez HR, Mitchell DA.

Nano Lett. 2018 Oct 10;18(10):6195-6206. doi: 10.1021/acs.nanolett.8b02179. Epub 2018 Sep 27.


Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes.

Sayour EJ, Mendez-Gomez HR, Mitchell DA.

Int J Mol Sci. 2018 Sep 23;19(10). pii: E2890. doi: 10.3390/ijms19102890. Review.


Temozolomide for immunomodulation in the treatment of glioblastoma.

Karachi A, Dastmalchi F, Mitchell DA, Rahman M.

Neuro Oncol. 2018 Nov 12;20(12):1566-1572. doi: 10.1093/neuonc/noy072. Review.


Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma.

Wildes TJ, Grippin A, Dyson KA, Wummer BM, Damiani DJ, Abraham RS, Flores CT, Mitchell DA.

Clin Cancer Res. 2018 Aug 15;24(16):3955-3966. doi: 10.1158/1078-0432.CCR-17-3061. Epub 2018 Apr 30.


The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas.

Mu L, Long Y, Yang C, Jin L, Tao H, Ge H, Chang YE, Karachi A, Kubilis PS, De Leon G, Qi J, Sayour EJ, Mitchell DA, Lin Z, Huang J.

Front Mol Neurosci. 2018 Mar 28;11:82. doi: 10.3389/fnmol.2018.00082. eCollection 2018.


CD4+ and Perivascular Foxp3+ T Cells in Glioma Correlate with Angiogenesis and Tumor Progression.

Mu L, Yang C, Gao Q, Long Y, Ge H, DeLeon G, Jin L, Chang YE, Sayour EJ, Ji J, Jiang J, Kubilis PS, Qi J, Gu Y, Wang J, Song Y, Mitchell DA, Lin Z, Huang J.

Front Immunol. 2017 Nov 7;8:1451. doi: 10.3389/fimmu.2017.01451. eCollection 2017.


Translational nanoparticle engineering for cancer vaccines.

Grippin AJ, Sayour EJ, Mitchell DA.

Oncoimmunology. 2017 Feb 22;6(10):e1290036. doi: 10.1080/2162402X.2017.1290036. eCollection 2017. Review.


Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.

Reap EA, Suryadevara CM, Batich KA, Sanchez-Perez L, Archer GE, Schmittling RJ, Norberg PK, Herndon JE 2nd, Healy P, Congdon KL, Gedeon PC, Campbell OC, Swartz AM, Riccione KA, Yi JS, Hossain-Ibrahim MK, Saraswathula A, Nair SK, Dunn-Pirio AM, Broome TM, Weinhold KJ, Desjardins A, Vlahovic G, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Fecci PE, Mitchell DA, Sampson JH.

Cancer Res. 2018 Jan 1;78(1):256-264. doi: 10.1158/0008-5472.CAN-17-0469. Epub 2017 Nov 1.

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