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Interaction of Structural Glycoprotein E2 of Classical Swine Fever Virus with Protein Phosphatase 1 Catalytic Subunit Beta (PPP1CB).

Vuono EA, Ramirez-Medina E, Holinka LG, Baker-Branstetter R, Borca MV, Gladue DP.

Viruses. 2019 Mar 29;11(4). pii: E307. doi: 10.3390/v11040307.


Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum.

Gladue DP, Largo E, Holinka LG, Ramirez-Medina E, Vuono EA, Berggren KA, Risatti GR, Nieva JL, Borca MV.

Viruses. 2018 Aug 28;10(9). pii: E460. doi: 10.3390/v10090460.


Phylodynamics of parapoxvirus genus in Mexico (2007-2011).

Velazquez-Salinas L, Ramirez-Medina E, Bracht AJ, Hole K, Brito BP, Gladue DP, Carrillo C.

Infect Genet Evol. 2018 Nov;65:12-14. doi: 10.1016/j.meegid.2018.07.005. Epub 2018 Jul 4.


The L83L ORF of African swine fever virus strain Georgia encodes for a non-essential gene that interacts with the host protein IL-1β.

Borca MV, O'Donnell V, Holinka LG, Ramírez-Medina E, Clark BA, Vuono EA, Berggren K, Alfano M, Carey LB, Richt JA, Risatti GR, Gladue DP.

Virus Res. 2018 Apr 2;249:116-123. doi: 10.1016/j.virusres.2018.03.017. Epub 2018 Mar 29.


CRISPR-Cas9, a tool to efficiently increase the development of recombinant African swine fever viruses.

Borca MV, Holinka LG, Berggren KA, Gladue DP.

Sci Rep. 2018 Feb 16;8(1):3154. doi: 10.1038/s41598-018-21575-8.


A partial deletion within foot-and-mouth disease virus non-structural protein 3A causes clinical attenuation in cattle but does not prevent subclinical infection.

Stenfeldt C, Arzt J, Pacheco JM, Gladue DP, Smoliga GR, Silva EB, Rodriguez LL, Borca MV.

Virology. 2018 Mar;516:115-126. doi: 10.1016/j.virol.2018.01.008. Epub 2018 Jan 12.


Mutation-induced changes of transmembrane pore size revealed by combined ion-channel conductance and single vesicle permeabilization analyses.

Largo E, Gladue DP, Torralba J, Aguilella VM, Alcaraz A, Borca MV, Nieva JL.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1015-1021. doi: 10.1016/j.bbamem.2018.01.012. Epub 2018 Jan 6.


Early protection events in swine immunized with an experimental live attenuated classical swine fever marker vaccine, FlagT4G.

Holinka LG, O'Donnell V, Risatti GR, Azzinaro P, Arzt J, Stenfeldt C, Velazquez-Salinas L, Carlson J, Gladue DP, Borca MV.

PLoS One. 2017 May 24;12(5):e0177433. doi: 10.1371/journal.pone.0177433. eCollection 2017.


Development of a fluorescent ASFV strain that retains the ability to cause disease in swine.

Borca MV, O'Donnell V, Holinka LG, Sanford B, Azzinaro PA, Risatti GR, Gladue DP.

Sci Rep. 2017 Apr 24;7:46747. doi: 10.1038/srep46747.


Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge.

O'Donnell V, Risatti GR, Holinka LG, Krug PW, Carlson J, Velazquez-Salinas L, Azzinaro PA, Gladue DP, Borca MV.

J Virol. 2016 Dec 16;91(1). pii: e01760-16. doi: 10.1128/JVI.01760-16. Print 2017 Jan 1.


Association of the Host Immune Response with Protection Using a Live Attenuated African Swine Fever Virus Model.

Carlson J, O'Donnell V, Alfano M, Velazquez Salinas L, Holinka LG, Krug PW, Gladue DP, Higgs S, Borca MV.

Viruses. 2016 Oct 22;8(10). pii: E291.


The Ep152R ORF of African swine fever virus strain Georgia encodes for an essential gene that interacts with host protein BAG6.

Borca MV, O'Donnell V, Holinka LG, Rai DK, Sanford B, Alfano M, Carlson J, Azzinaro PA, Alonso C, Gladue DP.

Virus Res. 2016 Sep 2;223:181-9. doi: 10.1016/j.virusres.2016.07.013. Epub 2016 Aug 3.


Selective Factors Associated with the Evolution of Codon Usage in Natural Populations of Arboviruses.

Velazquez-Salinas L, Zarate S, Eschbaumer M, Pereira Lobo F, Gladue DP, Arzt J, Novella IS, Rodriguez LL.

PLoS One. 2016 Jul 25;11(7):e0159943. doi: 10.1371/journal.pone.0159943. eCollection 2016.


African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge.

O'Donnell V, Holinka LG, Sanford B, Krug PW, Carlson J, Pacheco JM, Reese B, Risatti GR, Gladue DP, Borca MV.

Virus Res. 2016 Aug 2;221:8-14. doi: 10.1016/j.virusres.2016.05.014. Epub 2016 May 12.


Recoding structural glycoprotein E2 in classical swine fever virus (CSFV) produces complete virus attenuation in swine and protects infected animals against disease.

Velazquez-Salinas L, Risatti GR, Holinka LG, O'Donnell V, Carlson J, Alfano M, Rodriguez LL, Carrillo C, Gladue DP, Borca MV.

Virology. 2016 Jul;494:178-89. doi: 10.1016/j.virol.2016.04.007. Epub 2016 Apr 26.


African Swine Fever Virus Georgia 2007 with a Deletion of Virulence-Associated Gene 9GL (B119L), when Administered at Low Doses, Leads to Virus Attenuation in Swine and Induces an Effective Protection against Homologous Challenge.

O'Donnell V, Holinka LG, Krug PW, Gladue DP, Carlson J, Sanford B, Alfano M, Kramer E, Lu Z, Arzt J, Reese B, Carrillo C, Risatti GR, Borca MV.

J Virol. 2015 Aug;89(16):8556-66. doi: 10.1128/JVI.00969-15. Epub 2015 Jun 10.


African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus.

O'Donnell V, Holinka LG, Gladue DP, Sanford B, Krug PW, Lu X, Arzt J, Reese B, Carrillo C, Risatti GR, Borca MV.

J Virol. 2015 Jun;89(11):6048-56. doi: 10.1128/JVI.00554-15. Epub 2015 Mar 25.


The progressive adaptation of a georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major modifications of the viral genome.

Krug PW, Holinka LG, O'Donnell V, Reese B, Sanford B, Fernandez-Sainz I, Gladue DP, Arzt J, Rodriguez L, Risatti GR, Borca MV.

J Virol. 2015 Feb;89(4):2324-32. doi: 10.1128/JVI.03250-14. Epub 2014 Dec 10.


Interaction of CSFV E2 protein with swine host factors as detected by yeast two-hybrid system.

Gladue DP, Baker-Bransetter R, Holinka LG, Fernandez-Sainz IJ, O'Donnell V, Fletcher P, Lu Z, Borca MV.

PLoS One. 2014 Jan 8;9(1):e85324. doi: 10.1371/journal.pone.0085324. eCollection 2014.


Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function.

Largo E, Gladue DP, Huarte N, Borca MV, Nieva JL.

Antiviral Res. 2014 Jan;101:30-6. doi: 10.1016/j.antiviral.2013.10.015. Epub 2013 Nov 2.


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