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Items: 1 to 20 of 51


Human antibodies neutralizing diphtheria toxin in vitro and in vivo.

Wenzel EV, Bosnak M, Tierney R, Schubert M, Brown J, Dübel S, Efstratiou A, Sesardic D, Stickings P, Hust M.

Sci Rep. 2020 Jan 17;10(1):571. doi: 10.1038/s41598-019-57103-5.


A Cell Line for Detection of Botulinum Neurotoxin Type B.

Rust A, Doran C, Hart R, Binz T, Stickings P, Sesardic D, Peden AA, Davletov B.

Front Pharmacol. 2017 Nov 9;8:796. doi: 10.3389/fphar.2017.00796. eCollection 2017.


The European AntibotABE Framework Program and Its Update: Development of Innovative Botulinum Antibodies.

Rasetti-Escargueil C, Avril A, Miethe S, Mazuet C, Derman Y, Selby K, Thullier P, Pelat T, Urbain R, Fontayne A, Korkeala H, Sesardic D, Hust M, Popoff MR.

Toxins (Basel). 2017 Oct 2;9(10). pii: E309. doi: 10.3390/toxins9100309. Review.


SiMa Cells for a Serotype Specific and Sensitive Cell-Based Neutralization Test for Botulinum Toxin A and E.

Bak N, Rajagopal S, Stickings P, Sesardic D.

Toxins (Basel). 2017 Jul 20;9(7). pii: E230. doi: 10.3390/toxins9070230.


Assessment of ELISA as endpoint in neuronal cell-based assay for BoNT detection using hiPSC derived neurons.

Pellett S, Tepp WH, Johnson EA, Sesardic D.

J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):1-6. doi: 10.1016/j.vascn.2017.04.013. Epub 2017 Apr 29.


Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindström M, Lista F, Lúquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC.

Toxins (Basel). 2017 Jan 18;9(1). pii: E38. doi: 10.3390/toxins9010038. Review.


Collaborative study for the calibration of a replacement International Standard for diphtheria toxoid for use in flocculation test.

Coombes L, Rigsby P, Sesardic D, Stickings P.

Biologicals. 2016 Nov;44(6):556-566. doi: 10.1016/j.biologicals.2016.07.005. Epub 2016 Sep 30.


Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody.

Derman Y, Selby K, Miethe S, Frenzel A, Liu Y, Rasetti-Escargueil C, Avril A, Pelat T, Urbain R, Fontayne A, Thullier P, Sesardic D, Lindström M, Hust M, Korkeala H.

Toxins (Basel). 2016 Sep 12;8(9). pii: E257. doi: 10.3390/toxins8090257.


Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B.

Miethe S, Mazuet C, Liu Y, Tierney R, Rasetti-Escargueil C, Avril A, Frenzel A, Thullier P, Pelat T, Urbain R, Fontayne A, Sesardic D, Hust M, Popoff MR.

PLoS One. 2016 Aug 25;11(8):e0161446. doi: 10.1371/journal.pone.0161446. eCollection 2016.


Recommended Immunological Strategies to Screen for Botulinum Neurotoxin-Containing Samples.

Simon S, Fiebig U, Liu Y, Tierney R, Dano J, Worbs S, Endermann T, Nevers MC, Volland H, Sesardic D, Dorner MB.

Toxins (Basel). 2015 Nov 26;7(12):5011-34. doi: 10.3390/toxins7124860.


Development of Human-Like scFv-Fc Neutralizing Botulinum Neurotoxin E.

Miethe S, Rasetti-Escargueil C, Avril A, Liu Y, Chahboun S, Korkeala H, Mazuet C, Popoff MR, Pelat T, Thullier P, Sesardic D, Hust M.

PLoS One. 2015 Oct 6;10(10):e0139905. doi: 10.1371/journal.pone.0139905. eCollection 2015.


Isolation of nanomolar scFvs of non-human primate origin, cross-neutralizing botulinum neurotoxins A1 and A2 by targeting their heavy chain.

Avril A, Miethe S, Popoff MR, Mazuet C, Chahboun S, Rasetti-Escargueil C, Sesardic D, Thullier P, Hust M, Pelat T.

BMC Biotechnol. 2015 Sep 17;15:86. doi: 10.1186/s12896-015-0206-0.


Development of human-like scFv-Fc antibodies neutralizing Botulinum toxin serotype B.

Rasetti-Escargueil C, Avril A, Chahboun S, Tierney R, Bak N, Miethe S, Mazuet C, Popoff MR, Thullier P, Hust M, Pelat T, Sesardic D.

MAbs. 2015;7(6):1161-77. doi: 10.1080/19420862.2015.1082016. Epub 2015 Sep 18.


Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library.

Miethe S, Rasetti-Escargueil C, Liu Y, Chahboun S, Pelat T, Avril A, Frenzel A, Schirrmann T, Thullier P, Sesardic D, Hust M.

MAbs. 2014 Mar-Apr;6(2):446-59. doi: 10.4161/mabs.27773. Epub 2014 Jan 9.


Calibration and commutability assessment of the 1st International Standard for Diphtheria Antitoxin Human.

Stickings P, Rigsby P, Coombes L, von Hunolstein C, Ralli L, Pinto A, Sesardic D.

Biologicals. 2013 Nov;41(6):384-92. doi: 10.1016/j.biologicals.2013.08.001. Epub 2013 Sep 5.


Synthetic self-assembling clostridial chimera for modulation of sensory functions.

Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B.

Bioconjug Chem. 2013 Oct 16;24(10):1750-9. doi: 10.1021/bc4003103. Epub 2013 Sep 20.


In vitro antigen ELISA for quality control of tetanus vaccines.

Coombes L, Tierney R, Rigsby P, Sesardic D, Stickings P.

Biologicals. 2012 Nov;40(6):466-72. doi: 10.1016/j.biologicals.2012.07.011. Epub 2012 Aug 13.


A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice.

Tierney R, Nakai T, Parkins CJ, Caposio P, Fairweather NF, Sesardic D, Jarvis MA.

Vaccine. 2012 Apr 26;30(20):3047-52. doi: 10.1016/j.vaccine.2012.02.043. Epub 2012 Mar 10.


A functional dual-coated (FDC) microtiter plate method to replace the botulinum toxin LD50 test.

Liu YY, Rigsby P, Sesardic D, Marks JD, Jones RG.

Anal Biochem. 2012 Jun 1;425(1):28-35. doi: 10.1016/j.ab.2012.02.038. Epub 2012 Mar 6.


Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin.

Chahboun S, Hust M, Liu Y, Pelat T, Miethe S, Helmsing S, Jones RG, Sesardic D, Thullier P.

BMC Biotechnol. 2011 Nov 23;11:113. doi: 10.1186/1472-6750-11-113.

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