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Int J Mol Sci. 2019 Feb 22;20(4). pii: E967. doi: 10.3390/ijms20040967.

Taste Receptors: New Players in Sperm Biology.

Author information

1
Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy. alice.luddi@unisi.it.
2
Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy. laura.governini@unisi.it.
3
Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, 80539 Munich, Germany. d.wilmskoetter@web.de.
4
Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, 80539 Munich, Germany. Thomas.Gudermann@lrz.uni-muenchen.de.
5
Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, 80539 Munich, Germany. ingrid.boekhoff@lrz.uni-muenchen.de.
6
Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy. paola.piomboni@unisi.it.

Abstract

Taste receptors were first described as sensory receptors located on the tongue, where they are expressed in small clusters of specialized epithelial cells. However, more studies were published in recent years pointing to an expression of these proteins not only in the oral cavity but throughout the body and thus to a physiological role beyond the tongue. The recent observation that taste receptors and components of the coupled taste transduction cascade are also expressed during the different phases of spermatogenesis as well as in mature spermatozoa from mouse to humans and the overlap between the ligand spectrum of taste receptors with compounds in the male and female reproductive organs makes it reasonable to assume that sperm "taste" these different cues in their natural microenvironments. This assumption is assisted by the recent observations of a reproductive phenotype of different mouse lines carrying a targeted deletion of a taste receptor gene as well as the finding of a significant correlation between human male infertility and some polymorphisms in taste receptors genes. In this review, we depict recent findings on the role of taste receptors in male fertility, especially focusing on their possible involvement in mechanisms underlying spermatogenesis and post testicular sperm maturation. We also highlight the impact of genetic deletions of taste receptors, as well as their polymorphisms on male reproduction.

KEYWORDS:

SNP; acrosome reaction; apoptosis; cAMP; calcium; epididymal sperm maturation; knockout mice; reproduction; sperm; spermatogenesis; spontaneous activity of GPCRs; taste receptor

PMID:
30813355
PMCID:
PMC6413048
DOI:
10.3390/ijms20040967
[Indexed for MEDLINE]
Free PMC Article

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