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Items: 1 to 20 of 35


DSPE-PEG Modification of α-Conotoxin TxID.

Zhao W, Xiong Y, Zhangsun D, Luo S.

Mar Drugs. 2019 Jun 8;17(6). pii: E342. doi: 10.3390/md17060342.


The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain.

Wang H, Li X, Zhangsun D, Yu G, Su R, Luo S.

Mar Drugs. 2019 May 5;17(5). pii: E265. doi: 10.3390/md17050265.


Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets.

Liu Y, Qian J, Sun Z, Zhangsun D, Luo S.

Mar Drugs. 2019 Apr 28;17(5). pii: E256. doi: 10.3390/md17050256.


d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability.

Ren J, Zhu X, Xu P, Li R, Fu Y, Dong S, Zhangsun D, Wu Y, Luo S.

Mar Drugs. 2019 Feb 28;17(3). pii: E142. doi: 10.3390/md17030142.


Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor.

Ning J, Li R, Ren J, Zhangsun D, Zhu X, Wu Y, Luo S.

Mar Drugs. 2018 Dec 13;16(12). pii: E507. doi: 10.3390/md16120507.


Discovery Methodology of Novel Conotoxins from Conus Species.

Fu Y, Li C, Dong S, Wu Y, Zhangsun D, Luo S.

Mar Drugs. 2018 Oct 30;16(11). pii: E417. doi: 10.3390/md16110417. Review.


Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist.

Yu J, Zhu X, Harvey PJ, Kaas Q, Zhangsun D, Craik DJ, Luo S.

J Med Chem. 2018 Oct 25;61(20):9256-9265. doi: 10.1021/acs.jmedchem.8b00967. Epub 2018 Oct 9.


Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists.

Yu J, Zhu X, Zhang L, Kudryavtsev D, Kasheverov I, Lei Y, Zhangsun D, Tsetlin V, Luo S.

Neuropharmacology. 2018 Sep 1;139:226-237. doi: 10.1016/j.neuropharm.2018.07.019. Epub 2018 Jul 17.


Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor.

Ren J, Li R, Ning J, Zhu X, Zhangsun D, Wu Y, Luo S.

Mar Drugs. 2018 Jun 20;16(6). pii: E215. doi: 10.3390/md16060215.


Effects of serum, enzyme, thiol, and forced degradation on the stabilities of αO-Conotoxin GeXIVA[1,2] and GeXIVA [1,4].

Yu S, Wu Y, Xu P, Wang S, Zhangsun D, Luo S.

Chem Biol Drug Des. 2018 May;91(5):1030-1041. doi: 10.1111/cbdd.13167. Epub 2018 Jan 30.


Expression in Escherichia coli of fusion protein comprising α-conotoxin TxIB and preservation of selectivity to nicotinic acetylcholine receptors in the purified product.

Yu J, Zhu X, Yang Y, Luo S, Zhangsun D.

Chem Biol Drug Des. 2018 Feb;91(2):349-358. doi: 10.1111/cbdd.13104. Epub 2017 Sep 25.


α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.

Wu Y, Zhangsun D, Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S.

J Med Chem. 2017 Jul 13;60(13):5826-5833. doi: 10.1021/acs.jmedchem.7b00546. Epub 2017 Jun 21.


αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.

Zhangsun D, Zhu X, Kaas Q, Wu Y, Craik DJ, McIntosh JM, Luo S.

Neuropharmacology. 2017 Dec;127:243-252. doi: 10.1016/j.neuropharm.2017.04.015. Epub 2017 Apr 14.


From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR.

Lin B, Xu M, Zhu X, Wu Y, Liu X, Zhangsun D, Hu Y, Xiang SH, Kasheverov IE, Tsetlin VI, Wang X, Luo S.

Sci Rep. 2016 Mar 1;6:22349. doi: 10.1038/srep22349.


Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli.

Zhu X, Bi J, Yu J, Li X, Zhang Y, Zhangsun D, Luo S.

Mar Drugs. 2016 Jan 5;14(1):11. doi: 10.3390/md14010011.


Anti-hypersensitive effect of intramuscular administration of αO-conotoxin GeXIVA[1,2] and GeXIVA[1,4] in rats of neuropathic pain.

Li X, Hu Y, Wu Y, Huang Y, Yu S, Ding Q, Zhangsun D, Luo S.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Apr 3;66:112-9. doi: 10.1016/j.pnpbp.2015.12.005. Epub 2015 Dec 17.


Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, Craik DJ, McIntosh JM.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4026-35. doi: 10.1073/pnas.1503617112. Epub 2015 Jul 13.


Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.

Zhangsun D, Zhu X, Wu Y, Hu Y, Kaas Q, Craik DJ, McIntosh JM, Luo S.

J Biol Chem. 2015 Apr 10;290(15):9855-62. doi: 10.1074/jbc.M114.632646. Epub 2015 Feb 20.


Efficient expression of acetylcholine-binding protein from Aplysia californica in Bac-to-Bac system.

Lin B, Meng H, Bing H, Zhangsun D, Luo S.

Biomed Res Int. 2014;2014:691480. doi: 10.1155/2014/691480. Epub 2014 Jul 20.


Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA.

Wu Y, Wu X, Yu J, Zhu X, Zhangsun D, Luo S.

Molecules. 2014 Jan 15;19(1):966-79. doi: 10.3390/molecules19010966.

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