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J Med Food. 2018 Feb;21(2):159-166. doi: 10.1089/jmf.2017.4023. Epub 2018 Jan 3.

Deer Bone Extract Supplementation for Mild-to-Moderate Knee Osteoarthritis Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial.

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1 Nongshim Co. Ltd. , Seoul, Korea.
2 Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University , Seongnam, Korea.
3 Department of Food Science and Technology, Seoul National University of Science and Technology , Seoul, Korea.
4 WCU Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University , Seoul, Korea.


In this randomized, double-blind, placebo-controlled study, we evaluated the efficacy of deer bone extract (DBE) in participants with knee osteoarthritis (OA). We enrolled 50 participants aged 50-70 years, having knee OA with a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score ≥5.0. The participants were assigned to the placebo or DBE group (550 mg/day) for 12 weeks. The outcome measures were as follows: pain score on the visual analog scale (VAS); WOMAC score; and blood and urine biomarkers. In the DBE group, VAS scores, WOMAC total scores, and WOMAC subscores (for pain, stiffness, and physical function) improved significantly compared with the baseline values. However, there was no significant difference in outcomes between the DBE and placebo groups. The present findings suggest that DBE may mildly reduce joint pain and stiffness and improve joint function in patients with painful knee OA.


VAS pain score; WOMAC score; deer bone extract; osteoarthritis

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