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Items: 1 to 20 of 58


Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.

Hugelshofer M, Buzzi RM, Schaer CA, Richter H, Akeret K, Anagnostakou V, Mahmoudi L, Vaccani R, Vallelian F, Deuel JW, Kronen PW, Kulcsar Z, Regli L, Baek JH, Pires IS, Palmer AF, Dennler M, Humar R, Buehler PW, Kircher PR, Keller E, Schaer DJ.

J Clin Invest. 2019 Dec 2;129(12):5219-5235. doi: 10.1172/JCI130630.


Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland.

von Kempis J, Duetsch S, Reuschling N, Villiger R, Villiger PM, Vallelian F, Schaer DJ, Mueller RB.

Swiss Med Wkly. 2019 Mar 10;149:w20022. doi: 10.4414/smw.2019.20022. eCollection 2019 Feb 25.


Cell-Free Oxyhemoglobin in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage: Biomarker and Potential Therapeutic Target.

Hugelshofer M, Sikorski CM, Seule M, Deuel J, Muroi CI, Seboek M, Akeret K, Buzzi R, Regli L, Schaer DJ, Keller E.

World Neurosurg. 2018 Dec;120:e660-e666. doi: 10.1016/j.wneu.2018.08.141. Epub 2018 Aug 27.


Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease.

Yalamanoglu A, Deuel JW, Hunt RC, Baek JH, Hassell K, Redinius K, Irwin DC, Schaer DJ, Buehler PW.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L765-L774. doi: 10.1152/ajplung.00269.2018. Epub 2018 Jul 26.


Revisiting the putative role of heme as a trigger of inflammation.

Vallelian F, Schaer CA, Deuel JW, Ingoglia G, Humar R, Buehler PW, Schaer DJ.

Pharmacol Res Perspect. 2018 Mar 30;6(2):e00392. doi: 10.1002/prp2.392. eCollection 2018 Apr.


Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ.

BMC Biotechnol. 2018 Mar 15;18(1):15. doi: 10.1186/s12896-018-0424-3.


Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics.

Ferguson SK, Harral JW, Pak DI, Redinius KM, Stenmark KR, Schaer DJ, Buehler PW, Irwin DC.

Nitric Oxide. 2018 Jun 1;76:29-36. doi: 10.1016/j.niox.2018.03.005. Epub 2018 Mar 8.


Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.

Baek JH, Yalamanoglu A, Gao Y, Guenster R, Spahn DR, Schaer DJ, Buehler PW.

JCI Insight. 2017 May 4;2(9). pii: 93577. doi: 10.1172/jci.insight.93577. eCollection 2017 May 4.


Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis.

Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ.

Am J Respir Crit Care Med. 2016 May 15;193(10):1111-22. doi: 10.1164/rccm.201510-2058OC.


Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity.

Deuel JW, Vallelian F, Schaer CA, Puglia M, Buehler PW, Schaer DJ.

Free Radic Biol Med. 2015 Dec;89:931-43. doi: 10.1016/j.freeradbiomed.2015.09.016. Epub 2015 Oct 22.


Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex.

Vallelian F, Garcia-Rubio I, Puglia M, Kahraman A, Deuel JW, Engelsberger WR, Mason RP, Buehler PW, Schaer DJ.

Free Radic Biol Med. 2015 Aug;85:259-68. doi: 10.1016/j.freeradbiomed.2015.04.023. Epub 2015 Apr 28.


Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.

Gelderman MP, Baek JH, Yalamanoglu A, Puglia M, Vallelian F, Burla B, Vostal J, Schaer DJ, Buehler PW.

Haematologica. 2015 May;100(5):611-22. doi: 10.3324/haematol.2014.117325. Epub 2015 Jan 23.


Integrative proteome and transcriptome analysis of extramedullary erythropoiesis and its reversal by transferrin treatment in a mouse model of beta-thalassemia.

Vallelian F, Gelderman-Fuhrmann MP, Schaer CA, Puglia M, Opitz L, Baek JH, Vostal J, Buehler PW, Schaer DJ.

J Proteome Res. 2015 Feb 6;14(2):1089-100. doi: 10.1021/pr5010778. Epub 2015 Jan 23.


Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.

Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW.

Front Physiol. 2014 Oct 28;5:415. doi: 10.3389/fphys.2014.00415. eCollection 2014. Review.


Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.

Boretti FS, Baek JH, Palmer AF, Schaer DJ, Buehler PW.

Front Physiol. 2014 Oct 9;5:385. doi: 10.3389/fphys.2014.00385. eCollection 2014.


Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin.

Baek JH, Zhang X, Williams MC, Schaer DJ, Buehler PW, D'Agnillo F.

Toxins (Basel). 2014 Mar 31;6(4):1244-59. doi: 10.3390/toxins6041244.


Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent.

Schaer CA, Laczko E, Schoedon G, Schaer DJ, Vallelian F.

Oxid Med Cell Longev. 2013;2013:870472. doi: 10.1155/2013/870472. Epub 2013 Jun 11.


Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies.

Schaer DJ, Buehler PW.

Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433. Review.


Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ.

Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33. doi: 10.1089/ars.2012.5089. Epub 2013 Mar 28.


Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM.

Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Review.

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