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Items: 1 to 20 of 42


Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization.

Astakhova A, Chistyakov D, Thomas D, Geisslinger G, Brüne B, Sergeeva M, Namgaladze D.

Cells. 2019 Oct 1;8(10). pii: E1185. doi: 10.3390/cells8101185.


ER-Mitochondria Communication in Cells of the Innate Immune System.

Namgaladze D, Khodzhaeva V, Brüne B.

Cells. 2019 Sep 15;8(9). pii: E1088. doi: 10.3390/cells8091088. Review.


Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation.

Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, Fuhrmann D, Petcherski A, Heringdorf DMZ, Radeke HH, Brüne B.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep;1864(9):1235-1246. doi: 10.1016/j.bbalip.2019.05.008. Epub 2019 May 23.


Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.

Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, Brüne B.

Front Immunol. 2018 Dec 4;9:2858. doi: 10.3389/fimmu.2018.02858. eCollection 2018.


IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors.

Gupta S, Jain A, Syed SN, Snodgrass RG, Pflüger-Müller B, Leisegang MS, Weigert A, Brandes RP, Ebersberger I, Brüne B, Namgaladze D.

Oncoimmunology. 2018 Jul 30;7(10):e1494110. doi: 10.1080/2162402X.2018.1494110. eCollection 2018.


A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.

Snodgrass RG, Zezina E, Namgaladze D, Gupta S, Angioni C, Geisslinger G, Lütjohann D, Brüne B.

Front Immunol. 2018 Aug 24;9:1906. doi: 10.3389/fimmu.2018.01906. eCollection 2018.


Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.

Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP.

Nat Commun. 2018 Jun 12;9(1):2292. doi: 10.1038/s41467-018-04602-0.


AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages.

Kirchner J, Brüne B, Namgaladze D.

Sci Rep. 2018 May 17;8(1):7801. doi: 10.1038/s41598-018-26102-3.


Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses.

Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Apr;1863(4):433-446. doi: 10.1016/j.bbalip.2018.01.009.


Cancer cell and macrophage cross-talk in the tumor microenvironment.

Dehne N, Mora J, Namgaladze D, Weigert A, Brüne B.

Curr Opin Pharmacol. 2017 Aug;35:12-19. doi: 10.1016/j.coph.2017.04.007. Epub 2017 May 21. Review.


Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation.

Namgaladze D, Brüne B.

Biochim Biophys Acta. 2016 Nov;1861(11):1796-1807. doi: 10.1016/j.bbalip.2016.09.002. Epub 2016 Sep 7. Review.


AMPK-independent inhibition of human macrophage ER stress response by AICAR.

Boß M, Newbatt Y, Gupta S, Collins I, Brüne B, Namgaladze D.

Sci Rep. 2016 Aug 26;6:32111. doi: 10.1038/srep32111.


AMPK activates LXRα and ABCA1 expression in human macrophages.

Kemmerer M, Wittig I, Richter F, Brüne B, Namgaladze D.

Int J Biochem Cell Biol. 2016 Sep;78:1-9. doi: 10.1016/j.biocel.2016.06.014. Epub 2016 Jun 22.


Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy.

Derlet A, Rasper T, Roy Choudhury A, Bothur S, Rieger MA, Namgaladze D, Fischer A, Schürmann C, Brandes RP, Tschulena U, Steppan S, Assmus B, Dimmeler S, Zeiher AM, Seeger FH.

Stem Cells. 2016 Aug;34(8):2236-48. doi: 10.1002/stem.2394. Epub 2016 May 25.


Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress.

Snodgrass RG, Huang S, Namgaladze D, Jandali O, Shao T, Sama S, Brüne B, Hwang DH.

J Nutr Biochem. 2016 Jun;32:39-45. doi: 10.1016/j.jnutbio.2016.01.010. Epub 2016 Mar 8.


Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model.

Henke N, Ferreirós N, Geisslinger G, Ding MG, Essler S, Fuhrmann DC, Geis T, Namgaladze D, Dehne N, Brüne B.

Oncotarget. 2016 May 3;7(18):25915-29. doi: 10.18632/oncotarget.8297.


In vivo and ex vivo measurements: noninvasive assessment of alcoholic fatty liver using 1H-MR spectroscopy.

Keese D, Korkusuz H, Huebner F, Namgaladze D, Raschidi B, Vogl TJ.

Diagn Interv Radiol. 2016 Jan-Feb;22(1):13-21. doi: 10.5152/dir.2015.14331.


Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages.

Snodgrass RG, Boß M, Zezina E, Weigert A, Dehne N, Fleming I, Brüne B, Namgaladze D.

J Biol Chem. 2016 Jan 1;291(1):413-24. doi: 10.1074/jbc.M115.686709. Epub 2015 Nov 17.


AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages.

Namgaladze D, Snodgrass RG, Angioni C, Grossmann N, Dehne N, Geisslinger G, Brüne B.

J Biol Chem. 2015 Oct 2;290(40):24484-94. doi: 10.1074/jbc.M115.678243. Epub 2015 Aug 14.


AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.

Kemmerer M, Finkernagel F, Cavalcante MF, Abdalla DS, Müller R, Brüne B, Namgaladze D.

PLoS One. 2015 Jun 22;10(6):e0130893. doi: 10.1371/journal.pone.0130893. eCollection 2015.

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