Format

Send to

Choose Destination
J Asian Nat Prod Res. 2017 Feb;19(2):194-200. doi: 10.1080/10286020.2016.1196671. Epub 2016 Jun 22.

Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae).

Author information

1
a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.
2
b Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Sam Ratulangi , Manado 95115 , Indonesia.
3
c Faculty of Science, Department of Chemistry , University of Malaya , Kuala Lumpur 59100 , Malaysia.
4
d Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences , Osaka Prefecture University , Osaka 599-8531 , Japan.

Abstract

A new lanostane-type triterpenoid, 3β-hydroxy-25-ethyl-lanost-9(11),24(24')-diene (1), along with 3β-hydroxy-lanost-7-ene (2) and β-sitosterol-3-O-acetate (3) was isolated from the stem bark of C. cumingianus. The chemical structure of the new compound was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 μg/ml, respectively.

KEYWORDS:

Chisocheton cumingianus; Lanostane-type triterpenoid; Meliaceae; cytotoxic activity

PMID:
27329305
DOI:
10.1080/10286020.2016.1196671
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center