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Items: 1 to 20 of 33

1.

Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model.

Villarreal DO, Svoronos N, Wise MC, Shedlock DJ, Morrow MP, Conejo-Garcia JR, Weiner DB.

Vaccine. 2015 Aug 20;33(35):4313-20. doi: 10.1016/j.vaccine.2015.03.086. Epub 2015 Apr 14.

2.

Synthetic DNA approach to cytomegalovirus vaccine/immune therapy.

Wu SJ, Villarreal DO, Shedlock DJ, Weiner DB.

Adv Exp Med Biol. 2015;848:131-48. doi: 10.1007/978-1-4939-2432-5_7. Review.

3.

A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection.

Choi JH, Jonsson-Schmunk K, Qiu X, Shedlock DJ, Strong J, Xu JX, Michie KL, Audet J, Fernando L, Myers MJ, Weiner D, Bajrovic I, Tran LQ, Wong G, Bello A, Kobinger GP, Schafer SC, Croyle MA.

Mol Pharm. 2015 Aug 3;12(8):2712-31. doi: 10.1021/mp500646d. Epub 2014 Nov 14.

4.

Co-Administration of Molecular Adjuvants Expressing NF-Kappa B Subunit p65/RelA or Type-1 Transactivator T-bet Enhance Antigen Specific DNA Vaccine-Induced Immunity.

Shedlock DJ, Tingey C, Mahadevan L, Hutnick N, Reuschel EL, Kudchodkar S, Flingai S, Yan J, Kim JJ, Ugen KE, Weiner DB, Muthumani K.

Vaccines (Basel). 2014 Mar 25;2(2):196-215. doi: 10.3390/vaccines2020196.

5.

Induction of broad cytotoxic T cells by protective DNA vaccination against Marburg and Ebola.

Shedlock DJ, Aviles J, Talbott KT, Wong G, Wu SJ, Villarreal DO, Myles DJ, Croyle MA, Yan J, Kobinger GP, Weiner DB.

Mol Ther. 2013 Jul;21(7):1432-44. doi: 10.1038/mt.2013.61. Epub 2013 May 14.

6.

Synthetic DNA vaccine strategies against persistent viral infections.

Villarreal DO, Talbott KT, Choo DK, Shedlock DJ, Weiner DB.

Expert Rev Vaccines. 2013 May;12(5):537-54. doi: 10.1586/erv.13.33. Review.

7.

Induction of intrahepatic HCV NS4B, NS5A and NS5B-specific cellular immune responses following peripheral immunization.

Lang Kuhs KA, Toporovski R, Yan J, Ginsberg AA, Shedlock DJ, Weiner DB.

PLoS One. 2012;7(12):e52165. doi: 10.1371/journal.pone.0052165. Epub 2012 Dec 21. Erratum in: PLoS One. 2013;8(1). doi:10.1371/annotation/c338fb0b-b632-487d-96dd-d3ea666e5e26. Yan, Jian [added].

8.

Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice.

Shedlock DJ, Talbott KT, Wu SJ, Wilson CM, Muthumani K, Boyer JD, Sardesai NY, Awasthi S, Weiner DB.

Hum Vaccin Immunother. 2012 Nov 1;8(11):1668-81. doi: 10.4161/hv.22447. Epub 2012 Nov 1.

9.

Peripheral immunization induces functional intrahepatic hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver.

Lang Kuhs KA, Toporovski R, Ginsberg AA, Olsen AL, Shedlock DJ, Morrow MP, Yan J, Wells RG, Weiner DB.

Hum Vaccin. 2011 Dec;7(12):1326-35. doi: 10.4161/hv.7.12.18279. Epub 2011 Dec 1.

10.

HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells.

Muthumani K, Shedlock DJ, Choo DK, Fagone P, Kawalekar OU, Goodman J, Bian CB, Ramanathan AA, Atman P, Tebas P, Chattergoon MA, Choo AY, Weiner DB.

J Immunol. 2011 Sep 15;187(6):2932-43. doi: 10.4049/jimmunol.1100594. Epub 2011 Aug 19.

11.

Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine.

Belisle SE, Yin J, Shedlock DJ, Dai A, Yan J, Hirao L, Kutzler MA, Lewis MG, Andersen H, Lank SM, Karl JA, O'Connor DH, Khan A, Sardesai N, Chang J, Aicher L, Palermo RE, Weiner DB, Katze MG, Boyer J.

PLoS One. 2011;6(6):e19681. doi: 10.1371/journal.pone.0019681. Epub 2011 Jun 20.

12.

A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates.

Mallilankaraman K, Shedlock DJ, Bao H, Kawalekar OU, Fagone P, Ramanathan AA, Ferraro B, Stabenow J, Vijayachari P, Sundaram SG, Muruganandam N, Sarangan G, Srikanth P, Khan AS, Lewis MG, Kim JJ, Sardesai NY, Muthumani K, Weiner DB.

PLoS Negl Trop Dis. 2011 Jan 11;5(1):e928. doi: 10.1371/journal.pntd.0000928.

13.

A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge.

Shedlock DJ, Talbott KT, Cress C, Ferraro B, Tuyishme S, Mallilankaraman K, Cisper NJ, Morrow MP, Wu SJ, Kawalekar OU, Khan AS, Sardesai NY, Muthumani K, Shen H, Weiner DB.

Vaccine. 2011 Sep 9;29(39):6755-62. doi: 10.1016/j.vaccine.2010.12.064. Epub 2011 Jan 14.

14.

DNA vaccines for targeting bacterial infections.

Ingolotti M, Kawalekar O, Shedlock DJ, Muthumani K, Weiner DB.

Expert Rev Vaccines. 2010 Jul;9(7):747-63. doi: 10.1586/erv.10.57. Review.

15.

IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques.

Morrow MP, Yan J, Pankhong P, Shedlock DJ, Lewis MG, Talbott K, Toporovski R, Khan AS, Sardesai NY, Weiner DB.

Mol Ther. 2010 Sep;18(9):1714-23. doi: 10.1038/mt.2010.118. Epub 2010 Jun 22.

16.

Chikungunya: a potentially emerging epidemic?

Thiboutot MM, Kannan S, Kawalekar OU, Shedlock DJ, Khan AS, Sarangan G, Srikanth P, Weiner DB, Muthumani K.

PLoS Negl Trop Dis. 2010 Apr 27;4(4):e623. doi: 10.1371/journal.pntd.0000623. Review.

17.

Antibody-mediated neutralization of Ebola virus can occur by two distinct mechanisms.

Shedlock DJ, Bailey MA, Popernack PM, Cunningham JM, Burton DR, Sullivan NJ.

Virology. 2010 Jun 5;401(2):228-35. doi: 10.1016/j.virol.2010.02.029. Epub 2010 Mar 20.

18.

Current strategies and limitations of HIV vaccines.

Kawalekar OU, Shedlock DJ, Weiner DB.

Curr Opin Investig Drugs. 2010 Feb;11(2):192-202. Review. Erratum in: Curr Opin Investig Drugs. 2010 Mar;11(3):365.

PMID:
20112169
19.

Ki-67 staining for determination of rhesus macaque T cell proliferative responses ex vivo.

Shedlock DJ, Talbott KT, Morrow MP, Ferraro B, Hokey DA, Muthumani K, Weiner DB.

Cytometry A. 2010 Mar;77(3):275-84. doi: 10.1002/cyto.a.20857.

20.

Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials.

Shedlock DJ, Silvestri G, Weiner DB.

Nat Rev Immunol. 2009 Oct;9(10):717-28. doi: 10.1038/nri2636. Review.

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