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Items: 1 to 20 of 38


Telomeres and Longevity: A Cause or an Effect?

Adwan Shekhidem H, Sharvit L, Leman E, Manov I, Roichman A, Holtze S, M Huffman D, Y Cohen H, Bernd Hildebrandt T, Shams I, Atzmon G.

Int J Mol Sci. 2019 Jul 1;20(13). pii: E3233. doi: 10.3390/ijms20133233.


Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells.

Morrison EJ, Champagne DP, Dzieciatkowska M, Nemkov T, Zimring JC, Hansen KC, Guan F, Huffman DM, Santambrogio L, D'Alessandro A.

Nutrients. 2019 Jun 14;11(6). pii: E1337. doi: 10.3390/nu11061337.


Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.

Farias Quipildor GE, Mao K, Hu Z, Novaj A, Cui MH, Gulinello M, Branch CA, Gubbi S, Patel K, Moellering DR, Tarantini S, Kiss T, Yabluchanskiy A, Ungvari Z, Sonntag WE, Huffman DM.

Geroscience. 2019 Apr;41(2):185-208. doi: 10.1007/s11357-019-00065-3. Epub 2019 May 10.


Unexpected systemic phenotypes result from focal combined deficiencies of forebrain insulin receptor/IGF-1 receptor signaling.

Gandy S, Huffman DM.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):5852-5854. doi: 10.1073/pnas.1901970116. Epub 2019 Mar 11. No abstract available.


Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans.

Walters RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Qiu Y, Shah H, Wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, Fontana L, Kurland IJ, Barzilai N, Cuervo AM, Promislow DEL, Huffman DM.

Cell Rep. 2018 Oct 16;25(3):663-676.e6. doi: 10.1016/j.celrep.2018.09.065.


Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging.

Choi J, Rakhilin N, Gadamsetty P, Joe DJ, Tabrizian T, Lipkin SM, Huffman DM, Shen X, Nishimura N.

Sci Rep. 2018 Jul 20;8(1):10989. doi: 10.1038/s41598-018-29230-y.


Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice.

Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, Barzilai N, Huffman DM.

Nat Commun. 2018 Jun 19;9(1):2394. doi: 10.1038/s41467-018-04805-5.


Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis.

Guan F, Tabrizian T, Novaj A, Nakanishi M, Rosenberg DW, Huffman DM.

Front Nutr. 2018 May 31;5:37. doi: 10.3389/fnut.2018.00037. eCollection 2018.


40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain.

Gubbi S, Quipildor GF, Barzilai N, Huffman DM, Milman S.

J Mol Endocrinol. 2018 Jul;61(1):T171-T185. doi: 10.1530/JME-18-0093. Epub 2018 May 8. Review.


Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons.

Andrew MS, Huffman DM, Rodriguez-Ayala E, Williams NN, Peterson RM, Bastarrachea RA.

Surg Obes Relat Dis. 2018 Jun;14(6):833-841. doi: 10.1016/j.soard.2018.03.004. Epub 2018 Mar 9.


A simplified characterization of S-adenosyl-l-methionine-consuming enzymes with 1-Step EZ-MTase: a universal and straightforward coupled-assay for in vitro and in vivo setting.

Burgos ES, Walters RO, Huffman DM, Shechter D.

Chem Sci. 2017 Sep 1;8(9):6601-6612. doi: 10.1039/c7sc02830j. Epub 2017 Jul 27.


Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis.

Tabrizian T, Wang D, Guan F, Hu Z, Beck AP, Delahaye F, Huffman DM.

Endocr Relat Cancer. 2017 Jun;24(6):253-265. doi: 10.1530/ERC-16-0536. Epub 2017 Mar 28.


Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience.

Huffman DM, Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1395-1406. Epub 2016 Aug 16.


The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research.

Milman S, Huffman DM, Barzilai N.

Cell Metab. 2016 Jun 14;23(6):980-989. doi: 10.1016/j.cmet.2016.05.014. Review.


Energetic interventions for healthspan and resiliency with aging.

Huffman DM, Schafer MJ, LeBrasseur NK.

Exp Gerontol. 2016 Dec 15;86:73-83. doi: 10.1016/j.exger.2016.05.012. Epub 2016 May 31. Review.


Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.

Chusyd DE, Wang D, Huffman DM, Nagy TR.

Front Nutr. 2016 Apr 19;3:10. doi: 10.3389/fnut.2016.00010. eCollection 2016. Review.


Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.

Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P.

Aging (Albany NY). 2016 Apr;8(4):796-809. doi: 10.18632/aging.100943.


Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline.

Huffman DM, Farias Quipildor G, Mao K, Zhang X, Wan J, Apontes P, Cohen P, Barzilai N.

Aging Cell. 2016 Feb;15(1):181-6. doi: 10.1111/acel.12415. Epub 2015 Nov 4.


Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.

Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N.

Aging Cell. 2014 Aug;13(4):769-71. doi: 10.1111/acel.12213. Epub 2014 Mar 12.


Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.

Huffman DM, Augenlicht LH, Zhang X, Lofrese JJ, Atzmon G, Chamberland JP, Mantzoros CS.

Cancer Prev Res (Phila). 2013 Mar;6(3):177-87. doi: 10.1158/1940-6207.CAPR-12-0414.

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