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Oncotarget. 2017 Sep 21;8(60):102640-102652. doi: 10.18632/oncotarget.21123. eCollection 2017 Nov 24.

Apoptosis in the aging liver.

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Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China.
Department of Experimental Teaching Center, Nanchang University, Nanchang 330031, China.


Various changes in the liver during aging can reduce hepatic function and promote liver injury. Aging is associated with high morbidity and a poor prognosis in patients with various liver diseases, including nonalcoholic fatty liver disease, hepatitis C and liver cancer, as well as with surgeries such as partial hepatectomy and liver transplantation. In addition, apoptosis increases with liver aging. Because apoptosis is involved in regeneration, fibrosis and cancer prevention during liver aging, and restoration of the appropriate level of apoptosis can alleviate the adverse effects of liver aging, it is important to understand the mechanisms underlying this process. Herein, we elaborate on the causes of apoptosis during liver aging, with a focus on oxidative stress, genomic instability, lipotoxicity, endoplasmic reticulum stress, dysregulation of nutrient sensing, and liver stem/progenitor cell activity.


aging; apoptosis; genomic instability; liver; oxidative stress

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