Format

Send to

Choose Destination
Children (Basel). 2019 Apr 2;6(4). pii: E51. doi: 10.3390/children6040051.

Epinephrine in Neonatal Resuscitation.

Author information

1
UC Davis School of Medicine, Sacramento, CA 95817, USA. pvali@ucdavis.edu.
2
SUNY Buffalo, Buffalo, NY 14222, USA.
3
UC Davis School of Medicine, Sacramento, CA 95817, USA.

Abstract

Epinephrine is the only medication recommended by the International Liaison Committee on Resuscitation for use in newborn resuscitation. Strong evidence from large clinical trials is lacking owing to the infrequent use of epinephrine during neonatal resuscitation. Current recommendations are weak as they are extrapolated from animal models or pediatric and adult studies that do not adequately depict the transitioning circulation and fluid-filled lungs of the newborn in the delivery room. Many gaps in knowledge including the optimal dosing, best route and timing of epinephrine administration warrant further studies. Experiments on a well-established ovine model of perinatal asphyxial cardiac arrest closely mimicking the newborn infant provide important information that can guide future clinical trials.

KEYWORDS:

epinephrine; intramuscular; intraosseous; intravenous; newborn; resuscitation

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center