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Items: 1 to 20 of 32

1.

Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment.

Wang L, Guo C, Li X, Yu X, Li X, Xu K, Jiang B, Jia X, Li C, Shi D.

Eur J Med Chem. 2019 Sep 1;177:153-170. doi: 10.1016/j.ejmech.2019.05.044. Epub 2019 May 20.

PMID:
31132531
2.

Chalcone-analogue fluorescent probes for detecting thiophenols in seawater samples.

Liu H, Guo C, Guo S, Fan J, Wang L, Shi D.

Talanta. 2019 Aug 15;201:301-308. doi: 10.1016/j.talanta.2019.03.112. Epub 2019 Apr 3.

PMID:
31122427
3.

BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway.

Guo C, Wang L, Zhao Y, Jiang B, Luo J, Shi D.

Exp Ther Med. 2019 May;17(5):3848-3858. doi: 10.3892/etm.2019.7402. Epub 2019 Mar 18.

4.

Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents Through ROS-Mediated Apoptotic Pathway.

Xu K, Guo C, Shi D, Meng J, Tian H, Guo S.

Mar Drugs. 2019 Apr 2;17(4). pii: E207. doi: 10.3390/md17040207.

5.

Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.

Li C, Luo J, Guo S, Jia X, Guo C, Li X, Xu Q, Shi D.

Mol Pharm. 2019 May 6;16(5):1839-1850. doi: 10.1021/acs.molpharmaceut.8b01106. Epub 2019 Apr 18.

PMID:
30974944
6.

Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer.

Guo C, Wang L, Li X, Wang S, Yu X, Xu K, Zhao Y, Luo J, Li X, Jiang B, Shi D.

J Med Chem. 2019 Mar 28;62(6):3051-3067. doi: 10.1021/acs.jmedchem.8b01946. Epub 2019 Mar 19.

PMID:
30844273
7.

Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.

Li X, Xu Q, Li C, Luo J, Li X, Wang L, Jiang B, Shi D.

Eur J Med Chem. 2019 Mar 15;166:178-185. doi: 10.1016/j.ejmech.2019.01.057. Epub 2019 Jan 25.

PMID:
30711829
8.

Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells.

Liu H, Guo C, Guo S, Wang L, Shi D.

Molecules. 2019 Jan 21;24(2). pii: E375. doi: 10.3390/molecules24020375.

10.

Halogenated Compounds from Corals: Chemical Diversity and Biological Activities.

Zhang Y, Liu J, Shi D, Li Z.

Mini Rev Med Chem. 2018 Nov 13. doi: 10.2174/1389557518666181113124015. [Epub ahead of print]

PMID:
30421673
11.

Structural and Bioactive Studies of Halogenated Constituents from Sponges.

Li C, Shi D.

Curr Med Chem. 2018 Nov 11. doi: 10.2174/0929867325666181112092159. [Epub ahead of print]

PMID:
30417770
12.

Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1α/VEGF/Akt signaling pathway in human umbilical vein endothelial cells.

Guo C, Wang L, Jiang B, Shi D.

Anticancer Drugs. 2018 Nov;29(10):965-974. doi: 10.1097/CAD.0000000000000671.

PMID:
30335638
13.

Zinc-doped copper oxide nanocomposites reverse temozolomide resistance in glioblastoma by inhibiting AKT and ERK1/2.

Wu N, Zhang C, Wang C, Song L, Yao W, Gedanken A, Lin X, Shi D.

Nanomedicine (Lond). 2018 Jun;13(11):1303-1318. doi: 10.2217/nnm-2017-0359.

PMID:
29949469
14.

Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor.

Luo J, Xu Q, Jiang B, Zhang R, Jia X, Li X, Wang L, Guo C, Wu N, Shi D.

Br J Pharmacol. 2018 Jan;175(1):140-153. doi: 10.1111/bph.14080. Epub 2017 Dec 8.

15.

BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes.

Xu Q, Luo J, Wu N, Zhang R, Shi D.

Int J Biol Macromol. 2018 Jan;106:379-386. doi: 10.1016/j.ijbiomac.2017.08.042. Epub 2017 Aug 12.

PMID:
28811203
16.

A novel fluorinated thiosemicarbazone derivative- 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway.

Zhao Y, Guo C, Wang L, Wang S, Li X, Jiang B, Wu N, Guo S, Zhang R, Liu K, Shi D.

Biochem Biophys Res Commun. 2017 Sep 9;491(1):65-71. doi: 10.1016/j.bbrc.2017.07.042. Epub 2017 Jul 8.

PMID:
28698138
17.

Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity.

Zhang R, Song L, Jiang B, Wang L, Wu N, Guo S, Shi D.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2488-2492. doi: 10.1016/j.bmcl.2017.03.094. Epub 2017 Apr 2.

PMID:
28462838
18.

Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.

Zhang R, Yu R, Xu Q, Li X, Luo J, Jiang B, Wang L, Guo S, Wu N, Shi D.

Eur J Med Chem. 2017 Jul 7;134:24-33. doi: 10.1016/j.ejmech.2017.04.004. Epub 2017 Apr 4.

PMID:
28395151
19.

The Hot and Potential Targets of Type 2 Diabetes Mellitus Treatment in Recent Decade.

Xu Q, Wang L, Luo J, Shi D.

Curr Drug Targets. 2018;19(1):55-69. doi: 10.2174/1389450118666170307111714. Review.

PMID:
28270085
20.

The design strategy of selective PTP1B inhibitors over TCPTP.

Li X, Wang L, Shi D.

Bioorg Med Chem. 2016 Aug 15;24(16):3343-52. doi: 10.1016/j.bmc.2016.06.035. Epub 2016 Jun 18. Review.

PMID:
27353889

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