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Relation of Serum Plasmalogens and APOE Genotype to Cognition and Dementia in Older Persons in a Cross-Sectional Study.

Goodenowe DB, Senanayake V.

Brain Sci. 2019 Apr 24;9(4). pii: E92. doi: 10.3390/brainsci9040092.


Serum Metabolite Profiling for the Detection of Pancreatic Cancer: Results of a Large Independent Validation Study.

Akita H, Ritchie SA, Takemasa I, Eguchi H, Pastural E, Jin W, Yamazaki Y, Goodenowe DB, Nagano H, Monden M, Mori M, Doki Y.

Pancreas. 2016 Nov;45(10):1418-1423.


Improved specificity of serum phosphatidylcholine detection based on side-chain losses during negative electrospray ionization tandem mass spectrometry.

Ritchie SA, Jayasinge D, Wang L, Goodenowe DB.

Anal Bioanal Chem. 2016 Nov;408(27):7811-7823. Epub 2016 Aug 25.


Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study.

Senanayake VK, Jin W, Mochizuki A, Chitou B, Goodenowe DB.

BMC Neurol. 2015 Aug 27;15:154. doi: 10.1186/s12883-015-0411-4.


Pancreatic cancer serum biomarker PC-594: Diagnostic performance and comparison to CA19-9.

Ritchie SA, Chitou B, Zheng Q, Jayasinghe D, Jin W, Mochizuki A, Goodenowe DB.

World J Gastroenterol. 2015 Jun 7;21(21):6604-12. doi: 10.3748/wjg.v21.i21.6604.


Metabolic system alterations in pancreatic cancer patient serum: potential for early detection.

Ritchie SA, Akita H, Takemasa I, Eguchi H, Pastural E, Nagano H, Monden M, Doki Y, Mori M, Jin W, Sajobi TT, Jayasinghe D, Chitou B, Yamazaki Y, White T, Goodenowe DB.

BMC Cancer. 2013 Sep 12;13:416. doi: 10.1186/1471-2407-13-416.


Coupling deep transcriptome analysis with untargeted metabolic profiling in Ophiorrhiza pumila to further the understanding of the biosynthesis of the anti-cancer alkaloid camptothecin and anthraquinones.

Yamazaki M, Mochida K, Asano T, Nakabayashi R, Chiba M, Udomson N, Yamazaki Y, Goodenowe DB, Sankawa U, Yoshida T, Toyoda A, Totoki Y, Sakaki Y, Góngora-Castillo E, Buell CR, Sakurai T, Saito K.

Plant Cell Physiol. 2013 May;54(5):686-96. doi: 10.1093/pcp/pct040. Epub 2013 Mar 15.


Low-serum GTA-446 anti-inflammatory fatty acid levels as a new risk factor for colon cancer.

Ritchie SA, Tonita J, Alvi R, Lehotay D, Elshoni H, Myat S, McHattie J, Goodenowe DB.

Int J Cancer. 2013 Jan 15;132(2):355-62. doi: 10.1002/ijc.27673. Epub 2012 Jun 26.


Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease.

Wood PL, Smith T, Lane N, Khan MA, Ehrmantraut G, Goodenowe DB.

Lipids Health Dis. 2011 Dec 5;10:227. doi: 10.1186/1476-511X-10-227.


Cellular diamine levels in cancer chemoprevention: modulation by ibuprofen and membrane plasmalogens.

Wood PL, Khan MA, Smith T, Goodenowe DB.

Lipids Health Dis. 2011 Nov 16;10:214. doi: 10.1186/1476-511X-10-214.


In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor.

Wood PL, Khan MA, Smith T, Ehrmantraut G, Jin W, Cui W, Braverman NE, Goodenowe DB.

Lipids Health Dis. 2011 Oct 18;10:182. doi: 10.1186/1476-511X-10-182.


Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction.

Wood PL, Smith T, Pelzer L, Goodenowe DB.

Lipids Health Dis. 2011 Jun 17;10:102. doi: 10.1186/1476-511X-10-102.


Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity.

Ritchie SA, Jayasinghe D, Davies GF, Ahiahonu P, Ma H, Goodenowe DB.

J Exp Clin Cancer Res. 2011 May 17;30:59. doi: 10.1186/1756-9966-30-59.


Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age.

Ritchie SA, Heath D, Yamazaki Y, Grimmalt B, Kavianpour A, Krenitsky K, Elshoni H, Takemasa I, Miyake M, Sekimoto M, Monden M, Tomonaga T, Matsubara H, Sogawa K, Matsushita K, Nomura F, Goodenowe DB.

BMC Gastroenterol. 2010 Nov 29;10:140. doi: 10.1186/1471-230X-10-140.


Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study.

Mankidy R, Ahiahonu PW, Ma H, Jayasinghe D, Ritchie SA, Khan MA, Su-Myat KK, Wood PL, Goodenowe DB.

Lipids Health Dis. 2010 Jun 14;9:62. doi: 10.1186/1476-511X-9-62.


Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection.

Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB.

BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.


Circulating plasmalogen levels and Alzheimer Disease Assessment Scale-Cognitive scores in Alzheimer patients.

Wood PL, Mankidy R, Ritchie S, Heath D, Wood JA, Flax J, Goodenowe DB.

J Psychiatry Neurosci. 2010 Jan;35(1):59-62.


Novel plasma phospholipid biomarkers of autism: mitochondrial dysfunction as a putative causative mechanism.

Pastural E, Ritchie S, Lu Y, Jin W, Kavianpour A, Khine Su-Myat K, Heath D, Wood PL, Fisk M, Goodenowe DB.

Prostaglandins Leukot Essent Fatty Acids. 2009 Oct;81(4):253-64. doi: 10.1016/j.plefa.2009.06.003. Epub 2009 Jul 15.


Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia.

Goodenowe DB, Cook LL, Liu J, Lu Y, Jayasinghe DA, Ahiahonu PW, Heath D, Yamazaki Y, Flax J, Krenitsky KF, Sparks DL, Lerner A, Friedland RP, Kudo T, Kamino K, Morihara T, Takeda M, Wood PL.

J Lipid Res. 2007 Nov;48(11):2485-98. Epub 2007 Jul 30.


Triterpenoids from leaves of Elaeophorbia drupifera.

Ahiahonu PW, Goodenowe DB.

Fitoterapia. 2007 Jul;78(5):337-41. Epub 2007 Apr 11.


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