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Items: 1 to 20 of 368

1.

Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds.

Craik DJ, Lee MH, Rehm FBH, Tombling B, Doffek B, Peacock H.

Bioorg Med Chem. 2017 Aug 8. pii: S0968-0896(17)30932-X. doi: 10.1016/j.bmc.2017.08.005. [Epub ahead of print]

PMID:
28818463
2.

Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins.

Agwa AJ, Huang YH, Craik DJ, Henriques ST, Schroeder CI.

Toxins (Basel). 2017 Aug 12;9(8). pii: E248. doi: 10.3390/toxins9080248.

3.

Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties.

Troeira Henriques S, Lawrence N, Chaousis S, Ravipati AS, Cheneval O, Benfield AH, Elliott AG, Kavanagh AM, Cooper MA, Chan LY, Huang YH, Craik DJ.

ACS Chem Biol. 2017 Aug 8. doi: 10.1021/acschembio.7b00459. [Epub ahead of print]

PMID:
28741926
4.

Cyclotides as Tools in Chemical Biology.

de Veer SJ, Weidmann J, Craik DJ.

Acc Chem Res. 2017 Jul 18;50(7):1557-1565. doi: 10.1021/acs.accounts.7b00157. Epub 2017 Jun 23.

PMID:
28644007
5.

Editorial Overview.

Craik DJ, Henriques ST.

Curr Opin Chem Biol. 2017 Jun;38:iv-vi. doi: 10.1016/j.cbpa.2017.05.012. No abstract available.

PMID:
28619206
6.

Kalata B1 and Kalata B2 Have a Surfactant-Like Activity in Phosphatidylethanolomine-Containing Lipid Membranes.

Cranfield CG, Henriques ST, Martinac B, Duckworth P, Craik DJ, Cornell B.

Langmuir. 2017 Jul 5;33(26):6630-6637. doi: 10.1021/acs.langmuir.7b01642. Epub 2017 Jun 21.

PMID:
28605904
7.

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.

Wu Y, Zhangsun D, Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S.

J Med Chem. 2017 Jul 13;60(13):5826-5833. doi: 10.1021/acs.jmedchem.7b00546. Epub 2017 Jun 21.

PMID:
28603989
8.

Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin.

Ravipati AS, Poth AG, Troeira Henriques S, Bhandari M, Huang YH, Nino J, Colgrave ML, Craik DJ.

J Nat Prod. 2017 May 26;80(5):1522-1530. doi: 10.1021/acs.jnatprod.7b00061. Epub 2017 May 4.

PMID:
28471681
9.

Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake.

Ojeda PG, Henriques ST, Pan Y, Nicolazzo JA, Craik DJ, Wang CK.

Biopolymers. 2017 Apr 29. doi: 10.1002/bip.23025. [Epub ahead of print]

PMID:
28459137
10.

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.

Zhangsun D, Zhu X, Kaas Q, Wu Y, Craik DJ, McIntosh JM, Luo S.

Neuropharmacology. 2017 Apr 14. pii: S0028-3908(17)30156-9. doi: 10.1016/j.neuropharm.2017.04.015. [Epub ahead of print]

PMID:
28416445
11.

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.

Grage SL, Sani MA, Cheneval O, Henriques ST, Schalck C, Heinzmann R, Mylne JS, Mykhailiuk PK, Afonin S, Komarov IV, Separovic F, Craik DJ, Ulrich AS.

Biophys J. 2017 Feb 28;112(4):630-642. doi: 10.1016/j.bpj.2016.12.040.

PMID:
28256223
12.

Cyclotides as drug design scaffolds.

Craik DJ, Du J.

Curr Opin Chem Biol. 2017 Jun;38:8-16. doi: 10.1016/j.cbpa.2017.01.018. Epub 2017 Feb 27. Review.

PMID:
28249194
13.

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.

Kubota T, Durek T, Dang B, Finol-Urdaneta RK, Craik DJ, Kent SB, French RJ, Bezanilla F, Correa AM.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1857-E1865. doi: 10.1073/pnas.1700453114. Epub 2017 Feb 15.

14.

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.

Agwa AJ, Lawrence N, Deplazes E, Cheneval O, Chen RM, Craik DJ, Schroeder CI, Henriques ST.

Biochim Biophys Acta. 2017 May;1859(5):835-844. doi: 10.1016/j.bbamem.2017.01.020. Epub 2017 Jan 20.

PMID:
28115115
15.

Cyclotide Structure and Function: The Role of Membrane Binding and Permeation.

Troeira Henriques S, Craik DJ.

Biochemistry. 2017 Feb 7;56(5):669-682. doi: 10.1021/acs.biochem.6b01212. Epub 2017 Jan 27. Review.

PMID:
28085267
16.

Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold.

Swedberg JE, Li CY, de Veer SJ, Wang CK, Craik DJ.

J Med Chem. 2017 Jan 26;60(2):658-667. doi: 10.1021/acs.jmedchem.6b01509. Epub 2017 Jan 18.

PMID:
28045523
17.

Isolation and Characterization of Cyclotides from Brazilian Psychotria: Significance in Plant Defense and Co-occurrence with Antioxidant Alkaloids.

Matsuura HN, Poth AG, Yendo AC, Fett-Neto AG, Craik DJ.

J Nat Prod. 2016 Dec 23;79(12):3006-3013. doi: 10.1021/acs.jnatprod.6b00492. Epub 2016 Nov 21.

PMID:
28006906
18.

Forward for ICCP2015 issue of Biopolymers Peptide Science.

Craik DJ, Wang CK.

Biopolymers. 2016 Nov;106(6):772-773. doi: 10.1002/bip.22989. No abstract available.

PMID:
27878993
19.

Characterization of a Bioactive Acyclotide from Palicourea rigida.

Pinto MF, Silva ON, Viana JC, Porto WF, Migliolo L, B da Cunha N, Gomes N Jr, Fensterseifer IC, Colgrave ML, Craik DJ, Dias SC, Franco OL.

J Nat Prod. 2016 Nov 23;79(11):2767-2773. Epub 2016 Nov 3.

PMID:
27809507
20.

Accurate de novo design of hyperstable constrained peptides.

Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D.

Nature. 2016 Oct 20;538(7625):329-335. doi: 10.1038/nature19791. Epub 2016 Sep 14.

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