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A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors.

Zdenek CN, Harris RJ, Kuruppu S, Youngman NJ, Dobson JS, Debono J, Khan M, Smith I, Yarski M, Harrich D, Sweeney C, Dunstan N, Allen L, Fry BG.

Toxins (Basel). 2019 Oct 16;11(10). pii: E600. doi: 10.3390/toxins11100600.


Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant.

Jin H, Sun Y, Li D, Lin MH, Lor M, Rustanti L, Harrich D.

MBio. 2019 Aug 27;10(4). pii: e01769-19. doi: 10.1128/mBio.01769-19.


Oxazole-Benzenesulfonamide Derivatives Inhibit HIV-1 Reverse Transcriptase Interaction with Cellular eEF1A and Reduce Viral Replication.

Rawle DJ, Li D, Wu Z, Wang L, Choong M, Lor M, Reid RC, Fairlie DP, Harris J, Tachedjian G, Poulsen SA, Harrich D.

J Virol. 2019 May 29;93(12). pii: e00239-19. doi: 10.1128/JVI.00239-19. Print 2019 Jun 15.


eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency.

Li D, Rawle DJ, Wu Z, Jin H, Lin MH, Lor M, Abbott CM, Harrich D.

Virology. 2019 Apr;530:65-74. doi: 10.1016/j.virol.2019.01.023. Epub 2019 Jan 29.


The eukaryotic translation elongation factor 1A regulation of actin stress fibers is important for infectious RSV production.

Snape N, Li D, Wei T, Jin H, Lor M, Rawle DJ, Spann KM, Harrich D.

Virol J. 2018 Nov 26;15(1):182. doi: 10.1186/s12985-018-1091-7.


Toward the "unravelling" of HIV: Host cell factors involved in HIV-1 core uncoating.

Rawle DJ, Harrich D.

PLoS Pathog. 2018 Oct 4;14(10):e1007270. doi: 10.1371/journal.ppat.1007270. eCollection 2018 Oct. No abstract available.


HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain.

Rawle DJ, Li D, Swedberg JE, Wang L, Soares DC, Harrich D.

MBio. 2018 Mar 27;9(2). pii: e00316-18. doi: 10.1128/mBio.00316-18.


RNA glycosidase and other agents target Tat to inhibit HIV-1 transcription.

Harrich D, Jin H.

Biochem J. 2018 Mar 20;475(6):1059-1062. doi: 10.1042/BCJ20170669.


Differential Effects of Strategies to Improve the Transduction Efficiency of Lentiviral Vector that Conveys an Anti-HIV Protein, Nullbasic, in Human T Cells.

Rustanti L, Jin H, Li D, Lor M, Sivakumaran H, Harrich D.

Virol Sin. 2018 Apr;33(2):142-152. doi: 10.1007/s12250-018-0004-7. Epub 2018 Mar 14.


A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes.

Rustanti L, Jin H, Lor M, Lin MH, Rawle DJ, Harrich D.

Virol J. 2017 Mar 14;14(1):52. doi: 10.1186/s12985-017-0705-9.


Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein.

Jin H, Li D, Sivakumaran H, Lor M, Rustanti L, Cloonan N, Wani S, Harrich D.

MBio. 2016 Jul 5;7(4). pii: e00518-16. doi: 10.1128/mBio.00518-16.


Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target.

Li D, Wei T, Rawle DJ, Qin F, Wang R, Soares DC, Jin H, Sivakumaran H, Lin MH, Spann K, Abbott CM, Harrich D.

PLoS Pathog. 2015 Dec 1;11(12):e1005289. doi: 10.1371/journal.ppat.1005289. eCollection 2015 Dec.


The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention.

Fulcher AJ, Sivakumaran H, Jin H, Rawle DJ, Harrich D, Jans DA.

Biochim Biophys Acta. 2016 Feb;1863(2):254-62. doi: 10.1016/j.bbamcr.2015.11.019. Epub 2015 Dec 2.


Binding of the eukaryotic translation elongation factor 1A with the 5'UTR of HIV-1 genomic RNA is important for reverse transcription.

Li D, Wei T, Jin H, Rose A, Wang R, Lin MH, Spann K, Harrich D.

Virol J. 2015 Aug 6;12:118. doi: 10.1186/s12985-015-0337-x.


A mutant tat protein inhibits HIV-1 reverse transcription by targeting the reverse transcription complex.

Lin MH, Apolloni A, Cutillas V, Sivakumaran H, Martin S, Li D, Wei T, Wang R, Jin H, Spann K, Harrich D.

J Virol. 2015 May;89(9):4827-36. doi: 10.1128/JVI.03440-14. Epub 2015 Feb 11.


A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.

Lin MH, Sivakumaran H, Jones A, Li D, Harper C, Wei T, Jin H, Rustanti L, Meunier FA, Spann K, Harrich D.

Retrovirology. 2014 Dec 14;11:121. doi: 10.1186/s12977-014-0121-9.


The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus.

Wei T, Li D, Marcial D, Khan M, Lin MH, Snape N, Ghildyal R, Harrich D, Spann K.

PLoS One. 2014 Dec 5;9(12):e114447. doi: 10.1371/journal.pone.0114447. eCollection 2014.


Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.

Dang NT, Sivakumaran H, Harrich D, Shaw PN, Davis-Poynter N, Coombes AG.

Eur J Pharm Biopharm. 2014 Oct;88(2):406-14. doi: 10.1016/j.ejpb.2014.05.018. Epub 2014 Jun 2.


Evaluation of polycaprolactone matrices for sustained vaginal delivery of nevirapine in the prevention of heterosexual HIV transmission.

Dang N, Sivakumaran H, Harrich D, Shaw PN, Coombes AGA.

J Pharm Sci. 2014 Jul;103(7):2107-2115. doi: 10.1002/jps.24030. Epub 2014 May 27.


An evaluation of polycaprolactone matrices for vaginal delivery of the antiviral, tenofovir, in preventing heterosexual transmission of HIV.

Dang NT, Sivakumaran H, Harrich D, Coombes AG.

J Pharm Sci. 2013 Oct;102(10):3725-35. doi: 10.1002/jps.23684. Epub 2013 Jul 31.


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