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Items: 1 to 20 of 146


Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified drinking water.

Johnson TB, Langin LM, Zhao J, Weimer JM, Pearce DA, Kovács AD.

Sci Rep. 2019 Oct 18;9(1):14962. doi: 10.1038/s41598-019-51488-z.


Biogeographical patterns in soil bacterial communities across the Arctic region.

Malard LA, Anwar MZ, Jacobsen CS, Pearce DA.

FEMS Microbiol Ecol. 2019 Sep 1;95(9). pii: fiz128. doi: 10.1093/femsec/fiz128.


Microbial community drivers of PK/NRP gene diversity in selected global soils.

Borsetto C, Amos GCA, da Rocha UN, Mitchell AL, Finn RD, Laidi RF, Vallin C, Pearce DA, Newsham KK, Wellington EMH.

Microbiome. 2019 May 22;7(1):78. doi: 10.1186/s40168-019-0692-8.


Spatial Variability of Antarctic Surface Snow Bacterial Communities.

Malard LA, Šabacká M, Magiopoulos I, Mowlem M, Hodson A, Tranter M, Siegert MJ, Pearce DA.

Front Microbiol. 2019 Mar 26;10:461. doi: 10.3389/fmicb.2019.00461. eCollection 2019.


Therapeutic landscape for Batten disease: current treatments and future prospects.

Johnson TB, Cain JT, White KA, Ramirez-Montealegre D, Pearce DA, Weimer JM.

Nat Rev Neurol. 2019 Mar;15(3):161-178. doi: 10.1038/s41582-019-0138-8. Review.


Characterization of a novel N-acylhomoserine lactonase, AidP, from Antarctic Planococcus sp.

See-Too WS, Convey P, Pearce DA, Chan KG.

Microb Cell Fact. 2018 Nov 17;17(1):179. doi: 10.1186/s12934-018-1024-6.


Searching for novel biomarkers using a mouse model of CLN3-Batten disease.

Timm D, Cain JT, Geraets RD, White KA, Koh SY, Kielian T, Pearce DA, Hastings ML, Weimer JM.

PLoS One. 2018 Aug 7;13(8):e0201470. doi: 10.1371/journal.pone.0201470. eCollection 2018.


Microbial diversity and biogeography in Arctic soils.

Malard LA, Pearce DA.

Environ Microbiol Rep. 2018 Dec;10(6):611-625. doi: 10.1111/1758-2229.12680. Epub 2018 Aug 20. Review.


Toxic Cyanobacteria in Svalbard: Chemical Diversity of Microcystins Detected Using a Liquid Chromatography Mass Spectrometry Precursor Ion Screening Method.

Kleinteich J, Puddick J, Wood SA, Hildebrand F, Laughinghouse HD IV, Pearce DA, Dietrich DR, Wilmotte A.

Toxins (Basel). 2018 Apr 3;10(4). pii: E147. doi: 10.3390/toxins10040147.


Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis.

Grünewald B, Lange MD, Werner C, O'Leary A, Weishaupt A, Popp S, Pearce DA, Wiendl H, Reif A, Pape HC, Toyka KV, Sommer C, Geis C.

Elife. 2017 Nov 14;6. pii: e28685. doi: 10.7554/eLife.28685.


Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease.

Nelson T, Pearce DA, Kovács AD.

Biosci Rep. 2017 Nov 23;37(6). pii: BSR20171229. doi: 10.1042/BSR20171229. Print 2017 Dec 22.


Complete genome of Arthrobacter alpinus strain R3.8, bioremediation potential unraveled with genomic analysis.

See-Too WS, Ee R, Lim YL, Convey P, Pearce DA, Mohidin TBM, Yin WF, Chan KG.

Stand Genomic Sci. 2017 Sep 6;12:52. doi: 10.1186/s40793-017-0264-0. eCollection 2017.


Extenuating Circumstances: Data Sharing: Leading Data-Driven Population Health.

Griese ER, Hsu BS, Pearce DA.

S D Med. 2017 Aug;70(8):374-375. No abstract available.


Pharmacological Effects on Ceroid Lipofuscin and Neuronal Structure in Cln3 ∆ex7/8 Mouse Brain Cultures.

Brenneman DE, Pearce DA, Kovacs A, DeFrees S.

J Mol Neurosci. 2017 Sep;63(1):100-114. doi: 10.1007/s12031-017-0962-5. Epub 2017 Aug 15.


Genetic ataxia telangiectasia porcine model phenocopies the multisystemic features of the human disease.

Beraldi R, Meyerholz DK, Savinov A, Kovács AD, Weimer JM, Dykstra JA, Geraets RD, Pearce DA.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2862-2870. doi: 10.1016/j.bbadis.2017.07.020. Epub 2017 Jul 23.


Detailed Clinical Phenotype and Molecular Genetic Findings in CLN3-Associated Isolated Retinal Degeneration.

Ku CA, Hull S, Arno G, Vincent A, Carss K, Kayton R, Weeks D, Anderson GW, Geraets R, Parker C, Pearce DA, Michaelides M, MacLaren RE, Robson AG, Holder GE, Heon E, Raymond FL, Moore AT, Webster AR, Pennesi ME.

JAMA Ophthalmol. 2017 Jul 1;135(7):749-760. doi: 10.1001/jamaophthalmol.2017.1401.


Characterisation of Arctic Bacterial Communities in the Air above Svalbard.

Cuthbertson L, Amores-Arrocha H, Malard LA, Els N, Sattler B, Pearce DA.

Biology (Basel). 2017 May 6;6(2). pii: E29. doi: 10.3390/biology6020029.


A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies.

Geraets RD, Langin LM, Cain JT, Parker CM, Beraldi R, Kovacs AD, Weimer JM, Pearce DA.

PLoS One. 2017 May 2;12(5):e0176526. doi: 10.1371/journal.pone.0176526. eCollection 2017.


Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity.

Cárcel-Trullols J, Kovács AD, Pearce DA.

J Cell Biochem. 2017 Nov;118(11):3883-3890. doi: 10.1002/jcb.26039. Epub 2017 May 23.


AidP, a novel N-Acyl homoserine lactonase gene from Antarctic Planococcus sp.

See-Too WS, Ee R, Lim YL, Convey P, Pearce DA, Yin WF, Chan KG.

Sci Rep. 2017 Feb 22;7:42968. doi: 10.1038/srep42968.

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