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Items: 1 to 20 of 33


Metabolomics Provide Sensitive Insights into the Impacts of Low Level Environmental Contamination on Fish Health-A Pilot Study.

Long SM, Tull DL, De Souza DP, Kouremenos KA, Dayalan S, McConville MJ, Hassell KL, Pettigrove VJ, Gagnon MM.

Metabolites. 2020 Jan 6;10(1). pii: E24. doi: 10.3390/metabo10010024.


SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly.

Bitew MA, Hofmann J, De Souza DP, Wawegama NK, Newton HJ, Sansom FM.

Cell Microbiol. 2019 Dec 24:e13154. doi: 10.1111/cmi.13154. [Epub ahead of print]


Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome.

Kang Y, Anderson AJ, Jackson TD, Palmer CS, De Souza DP, Fujihara KM, Stait T, Frazier AE, Clemons NJ, Tull D, Thorburn DR, McConville MJ, Ryan MT, Stroud DA, Stojanovski D.

Elife. 2019 Nov 4;8. pii: e48828. doi: 10.7554/eLife.48828.


Metabolite Changes in an Estuarine Annelid Following Sublethal Exposure to a Mixture of Zinc and Boscalid.

Sinclair GM, O'Brien AL, Keough M, de Souza DP, Dayalan S, Kanojia K, Kouremenos K, Tull DL, Coleman RA, Jones OAH, Long SM.

Metabolites. 2019 Oct 15;9(10). pii: E229. doi: 10.3390/metabo9100229.


Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters.

Kuba M, Neha N, De Souza DP, Dayalan S, Newson JPM, Tull D, McConville MJ, Sansom FM, Newton HJ.

Biochem J. 2019 Oct 15;476(19):2851-2867. doi: 10.1042/BCJ20190504.


Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages.

De Souza DP, Achuthan A, Lee MK, Binger KJ, Lee MC, Davidson S, Tull DL, McConville MJ, Cook AD, Murphy AJ, Hamilton JA, Fleetwood AJ.

J Clin Invest. 2019 Oct 1;129(10):4239-4244. doi: 10.1172/JCI127597.


Using metabolomics to assess the sub-lethal effects of zinc and boscalid on an estuarine polychaete worm over time.

Sinclair GM, O'Brien AL, Keough M, De Souza DP, Dayalan S, Kanojia K, Kouremenos K, Tull DL, Coleman RA, Jones OAH, Long SM.

Metabolomics. 2019 Jul 31;15(8):108. doi: 10.1007/s11306-019-1570-x.


Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.

Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K, Whitney PG, Fernandez-Ruiz D, Dähling S, Kastenmüller W, Jönsson J, Gressier E, Lew AM, Perdomo C, Kupz A, Figgett W, Mackay F, Oleshansky M, Russ BE, Parish IA, Kallies A, McConville MJ, Turner SJ, Gebhardt T, Bedoui S.

Immunity. 2019 Aug 20;51(2):285-297.e5. doi: 10.1016/j.immuni.2019.06.002. Epub 2019 Jul 1.


Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome.

Simpfendorfer KR, Wang N, Tull DL, De Souza DP, Nahid A, Mu A, Hocking DM, Pedersen JS, Wijburg OLC, McConville MJ, Strugnell RA.

Mol Med. 2019 Apr 3;25(1):12. doi: 10.1186/s10020-019-0077-2.


Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis.

Grant LK, Ftouni S, Nijagal B, De Souza DP, Tull D, McConville MJ, Rajaratnam SMW, Lockley SW, Anderson C.

Sci Rep. 2019 Mar 14;9(1):4428. doi: 10.1038/s41598-019-40353-8.


De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever.

Bitew MA, Khoo CA, Neha N, De Souza DP, Tull D, Wawegama NK, Newton HJ, Sansom FM.

J Biol Chem. 2018 Nov 30;293(48):18636-18645. doi: 10.1074/jbc.RA118.005190. Epub 2018 Oct 12.


NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease.

Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Wilcox SA, Ogura Y, Corr SC, Kanojia K, Kouremenos KA, De Souza DP, McConville MJ, Flavell RA, Gerlic M, Kile BT, Papenfuss AT, Putoczki TL, Radford-Smith GL, Masters SL.

Nat Commun. 2018 Sep 13;9(1):3728. doi: 10.1038/s41467-018-06125-0.


Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages.

Boyce KJ, De Souza DP, Dayalan S, Pasricha S, Tull D, McConville MJ, Andrianopoulos A.

mSphere. 2018 Mar 21;3(2). pii: e00056-18. doi: 10.1128/mSphere.00056-18. eCollection 2018 Mar-Apr.


Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment.

Best SA, De Souza DP, Kersbergen A, Policheni AN, Dayalan S, Tull D, Rathi V, Gray DH, Ritchie ME, McConville MJ, Sutherland KD.

Cell Metab. 2018 Apr 3;27(4):935-943.e4. doi: 10.1016/j.cmet.2018.02.006. Epub 2018 Mar 8.


Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex.

Kang Y, Stroud DA, Baker MJ, De Souza DP, Frazier AE, Liem M, Tull D, Mathivanan S, McConville MJ, Thorburn DR, Ryan MT, Stojanovski D.

Mol Cell. 2017 Aug 3;67(3):457-470.e5. doi: 10.1016/j.molcel.2017.06.014. Epub 2017 Jul 14.


Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis.

Kowalski GM, Hamley S, Selathurai A, Kloehn J, De Souza DP, O'Callaghan S, Nijagal B, Tull DL, McConville MJ, Bruce CR.

Sci Rep. 2016 Jun 7;6:27541. doi: 10.1038/srep27541.


Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.

Sedger LM, Tull DL, McConville MJ, De Souza DP, Rupasinghe TW, Williams SJ, Dayalan S, Lanzer D, Mackie H, Lam TC, Boyages J.

PLoS One. 2016 May 16;11(5):e0154650. doi: 10.1371/journal.pone.0154650. eCollection 2016.


In vivo cardiac glucose metabolism in the high-fat fed mouse: Comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach.

Kowalski GM, De Souza DP, Risis S, Burch ML, Hamley S, Kloehn J, Selathurai A, Lee-Young RS, Tull D, O'Callaghan S, McConville MJ, Bruce CR.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):818-24. doi: 10.1016/j.bbrc.2015.06.019. Epub 2015 Jun 15.


Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse.

Kowalski GM, De Souza DP, Burch ML, Hamley S, Kloehn J, Selathurai A, Tull D, O'Callaghan S, McConville MJ, Bruce CR.

Biochem Biophys Res Commun. 2015 Jun 19;462(1):27-32. doi: 10.1016/j.bbrc.2015.04.096. Epub 2015 Apr 28.


A multi-platform metabolomics approach demonstrates changes in energy metabolism and the transsulfuration pathway in Chironomus tepperi following exposure to zinc.

Long SM, Tull DL, Jeppe KJ, De Souza DP, Dayalan S, Pettigrove VJ, McConville MJ, Hoffmann AA.

Aquat Toxicol. 2015 May;162:54-65. doi: 10.1016/j.aquatox.2015.03.009. Epub 2015 Mar 10.


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