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Items: 1 to 20 of 126

1.

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer.

Vankova P, Salido E, Timson DJ, Man P, Pey AL.

Biomolecules. 2019 Nov 12;9(11). pii: E728. doi: 10.3390/biom9110728.

2.

Dynamic origins of substrate promiscuity in bacterial galactokinases.

McAuley M, Huang M, Timson DJ.

Carbohydr Res. 2019 Dec 1;486:107839. doi: 10.1016/j.carres.2019.107839. Epub 2019 Oct 17.

PMID:
31704571
3.

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model.

Eardley J, Dedi C, Dymond M, Hallsworth JE, Timson DJ.

Biotechnol Lett. 2019 Nov;41(11):1309-1318. doi: 10.1007/s10529-019-02737-8. Epub 2019 Sep 26.

PMID:
31559517
4.

Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.

Megarity CF, Timson DJ.

Biosci Rep. 2019 Sep 6;39(9). pii: BSR20191874. doi: 10.1042/BSR20191874. Print 2019 Sep 30.

5.

Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1).

Megarity CF, Abdel-Aal Bettley H, Caraher MC, Scott KA, Whitehead RC, Jowitt TA, Gutierrez A, Bryce RA, Nolan KA, Stratford IJ, Timson DJ.

Chembiochem. 2019 Nov 18;20(22):2841-2849. doi: 10.1002/cbic.201900313. Epub 2019 Sep 20.

PMID:
31165578
6.

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms.

Beaver SK, Mesa-Torres N, Pey AL, Timson DJ.

Biochim Biophys Acta Proteins Proteom. 2019 Jul - Aug;1867(7-8):663-676. doi: 10.1016/j.bbapap.2019.05.002. Epub 2019 May 12. Review.

PMID:
31091472
7.

Myosin Va and spermine synthase: partners in exosome transport.

Timson DJ.

Biosci Rep. 2019 Apr 30;39(4). pii: BSR20190326. doi: 10.1042/BSR20190326. Print 2019 Apr 30.

8.

Phosphorylation Mechanism of N-Acetyl-l-glutamate Kinase, a QM/MM Study.

McClory J, Hu GX, Zou JW, Timson DJ, Huang M.

J Phys Chem B. 2019 Apr 4;123(13):2844-2852. doi: 10.1021/acs.jpcb.9b00547. Epub 2019 Mar 21.

PMID:
30848915
9.

Fructose 1,6-bisphosphatase: getting the message across.

Timson DJ.

Biosci Rep. 2019 Mar 6;39(3). pii: BSR20190124. doi: 10.1042/BSR20190124. Print 2019 Mar 29.

10.

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study.

McClory J, Lin JT, Timson DJ, Zhang J, Huang M.

Org Biomol Chem. 2019 Feb 27;17(9):2423-2431. doi: 10.1039/c8ob03197e.

PMID:
30735219
11.

Characterization of Calcium-Binding Proteins from Parasitic Worms.

Thomas CM, Timson DJ.

Methods Mol Biol. 2019;1929:615-641. doi: 10.1007/978-1-4939-9030-6_39.

PMID:
30710301
12.

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places.

Pey AL, Megarity CF, Timson DJ.

Biosci Rep. 2019 Jan 3;39(1). pii: BSR20180459. doi: 10.1042/BSR20180459. Print 2019 Jan 31. Review.

13.

Type IV galactosemia.

Timson DJ.

Genet Med. 2019 Jun;21(6):1283-1285. doi: 10.1038/s41436-018-0359-z. Epub 2018 Nov 21. No abstract available.

PMID:
30459459
14.

The Mechanism of Action of Praziquantel: Six Hypotheses.

Thomas CM, Timson DJ.

Curr Top Med Chem. 2018;18(18):1575-1584. doi: 10.2174/1568026618666181029143214. Review.

PMID:
30370849
15.

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability.

McAuley M, Huang M, Timson DJ.

Bioorg Chem. 2018 Dec;81:649-657. doi: 10.1016/j.bioorg.2018.09.002. Epub 2018 Sep 19.

PMID:
30253338
16.

Water-mediated network in the resistance mechanism of fosfomycin.

McClory J, Lin JT, Timson DJ, Zhang J, Huang M.

Phys Chem Chem Phys. 2018 Aug 22;20(33):21660-21667. doi: 10.1039/c8cp02860e.

PMID:
30101239
17.

A galactokinase-like protein from the liver fluke Fasciola hepatica.

Zinsser VL, Cox C, McAuley M, Hoey EM, Trudgett A, Timson DJ.

Exp Parasitol. 2018 Sep;192:65-72. doi: 10.1016/j.exppara.2018.07.013. Epub 2018 Jul 21.

PMID:
30040960
18.

Calmodulins from Schistosoma mansoni: Biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels.

Thomas CM, Timson DJ.

Cell Calcium. 2018 Sep;74:1-13. doi: 10.1016/j.ceca.2018.05.006. Epub 2018 May 17.

PMID:
29802931
19.

Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.

McAuley M, Mesa-Torres N, McFall A, Morris S, Huang M, Pey AL, Timson DJ.

Chembiochem. 2018 May 18;19(10):1088-1095. doi: 10.1002/cbic.201800025. Epub 2018 Apr 26.

PMID:
29505688
20.

The tegumental allergen-like proteins of Schistosoma mansoni: A biochemical study of SmTAL4-TAL13.

Carson J, Thomas CM, McGinty A, Takata G, Timson DJ.

Mol Biochem Parasitol. 2018 Apr;221:14-22. doi: 10.1016/j.molbiopara.2018.02.002. Epub 2018 Feb 14.

PMID:
29453993

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