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Items: 1 to 20 of 83

1.

Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates.

Lamut A, Cruz CD, Skok Ž, Barančoková M, Zidar N, Zega A, Mašič LP, Ilaš J, Tammela P, Kikelj D, Tomašič T.

Bioorg Chem. 2019 Dec 23;95:103550. doi: 10.1016/j.bioorg.2019.103550. [Epub ahead of print]

PMID:
31911309
2.

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity.

Fois B, Skok Ž, Tomašič T, Ilaš J, Zidar N, Zega A, Peterlin Mašič L, Szili P, Draskovits G, Nyerges Á, Pál C, Kikelj D.

ChemMedChem. 2019 Nov 13. doi: 10.1002/cmdc.201900607. [Epub ahead of print]

PMID:
31721445
3.

Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets.

Skok Ž, Zidar N, Kikelj D, Ilaš J.

J Med Chem. 2019 Oct 21. doi: 10.1021/acs.jmedchem.9b00726. [Epub ahead of print]

PMID:
31592646
4.

Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques.

Campos LE, Garibotto FM, Angelina E, Kos J, Tomašič T, Zidar N, Kikelj D, Gonec T, Marvanova P, Mokry P, Jampilek J, Alvarez SE, Enriz RD.

Bioorg Chem. 2019 Oct;91:103125. doi: 10.1016/j.bioorg.2019.103125. Epub 2019 Jul 12.

PMID:
31401373
5.

New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors.

Zidar N, Macut H, Tomašič T, Peterlin Mašič L, Ilaš J, Zega A, Tammela P, Kikelj D.

Medchemcomm. 2019 May 20;10(6):1007-1017. doi: 10.1039/c9md00224c. eCollection 2019 Jun 1.

PMID:
31303999
6.

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria.

Lamut A, Peterlin Mašič L, Kikelj D, Tomašič T.

Med Res Rev. 2019 Nov;39(6):2460-2504. doi: 10.1002/med.21591. Epub 2019 Apr 19. Review.

PMID:
31004360
7.

An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.

Tiz DB, Skok Ž, Durcik M, Tomašič T, Mašič LP, Ilaš J, Zega A, Draskovits G, Révész T, Nyerges Á, Pál C, Cruz CD, Tammela P, Žigon D, Kikelj D, Zidar N.

Eur J Med Chem. 2019 Apr 1;167:269-290. doi: 10.1016/j.ejmech.2019.02.004. Epub 2019 Feb 10.

PMID:
30776691
8.

ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents.

Durcik M, Tomašič T, Zidar N, Zega A, Kikelj D, Mašič LP, Ilaš J.

Expert Opin Ther Pat. 2019 Mar;29(3):171-180. doi: 10.1080/13543776.2019.1575362. Epub 2019 Feb 6. Review.

PMID:
30686070
9.

Analogues of the Lignan Pinoresinol as Novel Lead Compounds for P-glycoprotein (P-gp) Inhibitors.

Laiolo J, Tomašič T, Vera DMA, González ML, Lanza PA, Gancedo SN, Hodnik Ž, Peterlin Mašič L, Kikelj D, Carpinella MC.

ACS Med Chem Lett. 2018 Nov 21;9(12):1186-1192. doi: 10.1021/acsmedchemlett.8b00324. eCollection 2018 Dec 13.

10.

Inhibition of Hepatitis C Replication by Targeting the Molecular Chaperone Hsp90: Synthesis and Biological Evaluation of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazole Derivatives.

Lillsunde KE, Tomašič T, Schult P, Lohmann V, Kikelj D, Tammela P.

ChemMedChem. 2019 Feb 5;14(3):334-342. doi: 10.1002/cmdc.201800724. Epub 2019 Jan 22.

PMID:
30548820
11.

Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity.

Žula A, Będziak I, Kikelj D, Ilaš J.

Mar Drugs. 2018 Oct 27;16(11). pii: E413. doi: 10.3390/md16110413.

12.

Recent progress in the discovery and development of DNA gyrase B inhibitors.

Barančoková M, Kikelj D, Ilaš J.

Future Med Chem. 2018 May 1;10(10):1207-1227. doi: 10.4155/fmc-2017-0257. Epub 2018 May 22. Review.

PMID:
29787300
13.

New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.

Durcik M, Lovison D, Skok Ž, Durante Cruz C, Tammela P, Tomašič T, Benedetto Tiz D, Draskovits G, Nyerges Á, Pál C, Ilaš J, Peterlin Mašič L, Kikelj D, Zidar N.

Eur J Med Chem. 2018 Jun 25;154:117-132. doi: 10.1016/j.ejmech.2018.05.011. Epub 2018 May 10.

14.

Overcoming problems of poor drug penetration into bacteria: challenges and strategies for medicinal chemists.

Benedetto Tiz D, Kikelj D, Zidar N.

Expert Opin Drug Discov. 2018 Jun;13(6):497-507. doi: 10.1080/17460441.2018.1455660. Epub 2018 Mar 23. Review.

PMID:
29566560
15.

Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors.

Tomašič T, Barančoková M, Zidar N, Ilaš J, Tammela P, Kikelj D.

Arch Pharm (Weinheim). 2018 Jan;351(1). doi: 10.1002/ardp.201700333. Epub 2017 Dec 14.

PMID:
29239018
16.

Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors.

Durcik M, Tammela P, Barančoková M, Tomašič T, Ilaš J, Kikelj D, Zidar N.

ChemMedChem. 2018 Jan 22;13(2):186-198. doi: 10.1002/cmdc.201700549. Epub 2018 Jan 8.

PMID:
29206345
17.

Benzothiazole-based Compounds in Antibacterial Drug Discovery.

Gjorgjieva M, Tomašič T, Kikelj D, Mašič LP.

Curr Med Chem. 2018;25(38):5218-5236. doi: 10.2174/0929867324666171009103327. Review.

PMID:
28990510
18.

Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.

Zidar N, Žula A, Tomašič T, Rogers M, Kirby RW, Tytgat J, Peigneur S, Kikelj D, Ilaš J, Mašič LP.

Eur J Med Chem. 2017 Oct 20;139:232-241. doi: 10.1016/j.ejmech.2017.08.015. Epub 2017 Aug 7.

PMID:
28802123
19.

Design, Synthesis, and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors.

Cotman AE, Trampuž M, Brvar M, Kikelj D, Ilaš J, Peterlin-Mašič L, Montalvão S, Tammela P, Frlan R.

Arch Pharm (Weinheim). 2017 Aug;350(8). doi: 10.1002/ardp.201700087. Epub 2017 Jun 16.

PMID:
28621824
20.

Marine alkaloid oroidin analogues with antiviral potential: A novel class of synthetic compounds targeting the cellular chaperone Hsp90.

Lillsunde KE, Tomašič T, Kikelj D, Tammela P.

Chem Biol Drug Des. 2017 Dec;90(6):1147-1154. doi: 10.1111/cbdd.13034. Epub 2017 Jul 3.

PMID:
28580714

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