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Nutrients. 2014 Sep 15;6(9):3641-52. doi: 10.3390/nu6093641.

Vitamin E concentrations in adults with HIV/AIDS on highly active antiretroviral therapy.

Author information

1
Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. daniellinhait@yahoo.com.br.
2
Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. phcrondo@usp.br.
3
Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. lianialuzia@usp.br.
4
Department of Epidemiology, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. jmpsouza@usp.br.
5
Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. alinefir@gmail.com.
6
Department of Medicine, Center for Biological and Health Sciences, Federal University of São Carlos, Rodovia Washington Luís, km 235, CEP-13565-905 São Carlos, Brazil. sigridsantos@uol.com.br.

Abstract

HIV/AIDS patients are probably more predisposed to vitamin E deficiency, considering that they are more exposed to oxidative stress. Additionally, there are an extensive number of drugs in the highly active antiretroviral therapy (HAART) regimens that may interfere with vitamin E concentrations. The objective of this study was to compare serum concentrations of alpha-tocopherol in 182 HIV/AIDS patients receiving different HAART regimens. The patients were divided into three groups according to regimen: nucleoside analog reverse-transcriptase inhibitors (NRTIs) + non-nucleoside analog reverse-transcriptase inhibitors (NNRTIs); NRTIs + protease inhibitors + ritonavir; NRTIs + other classes. Alpha-tocopherol was assessed by high-performance liquid chromatography. Multiple linear regression analysis was used to evaluate the effects of HAART regimen, time of use, and compliance with the regimen on alpha-tocopherol concentrations. Alpha-tocopherol concentrations were on average 4.12 μmol/L lower for the NRTIs + other classes regimen when compared to the NRTIs + NNRTIs regimen (p = 0.037). A positive association (p < 0.001) was observed between alpha-tocopherol and cholesterol concentrations, a finding due, in part, to the relationship between liposoluble vitamins and lipid profile. This study demonstrated differences in alpha-tocopherol concentrations between patients using different HAART regimens, especially regimens involving the use of new drugs. Long-term prospective cohort studies are needed to monitor vitamin E status in HIV/AIDS patients since the beginning of treatment.

PMID:
25225815
PMCID:
PMC4179180
DOI:
10.3390/nu6093641
[Indexed for MEDLINE]
Free PMC Article

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