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Items: 1 to 20 of 40

1.

Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia.

Funken M, Malan D, Sasse P, Bruegmann T.

Front Physiol. 2019 Apr 24;10:498. doi: 10.3389/fphys.2019.00498. eCollection 2019.

2.

Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision.

Makowka P, Bruegmann T, Dusend V, Malan D, Beiert T, Hesse M, Fleischmann BK, Sasse P.

Nat Commun. 2019 Mar 20;10(1):1281. doi: 10.1038/s41467-019-09322-7.

3.

Optical control of L-type Ca2+ channels using a diltiazem photoswitch.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D.

Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16.

PMID:
30013061
4.

Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation.

Rehnelt S, Malan D, Juhasz K, Wolters B, Doerr L, Beckler M, Kettenhofen R, Bohlen H, Bruegmann T, Sasse P.

Int J Mol Sci. 2017 Dec 6;18(12). pii: E2634. doi: 10.3390/ijms18122634.

5.

Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes.

Lapp H, Bruegmann T, Malan D, Friedrichs S, Kilgus C, Heidsieck A, Sasse P.

Sci Rep. 2017 Aug 29;7(1):9629. doi: 10.1038/s41598-017-09760-7.

6.

EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival.

Jara-Avaca M, Kempf H, Rückert M, Robles-Diaz D, Franke A, de la Roche J, Fischer M, Malan D, Sasse P, Solodenko W, Dräger G, Kirschning A, Martin U, Zweigerdt R.

Stem Cell Reports. 2017 Feb 14;8(2):305-317. doi: 10.1016/j.stemcr.2016.12.012. Epub 2017 Jan 12.

7.

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice.

Monnerat G, Alarcón ML, Vasconcellos LR, Hochman-Mendez C, Brasil G, Bassani RA, Casis O, Malan D, Travassos LH, Sepúlveda M, Burgos JI, Vila-Petroff M, Dutra FF, Bozza MT, Paiva CN, Carvalho AB, Bonomo A, Fleischmann BK, de Carvalho ACC, Medei E.

Nat Commun. 2016 Nov 24;7:13344. doi: 10.1038/ncomms13344.

8.

Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.

Malan D, Zhang M, Stallmeyer B, Müller J, Fleischmann BK, Schulze-Bahr E, Sasse P, Greber B.

Basic Res Cardiol. 2016 Mar;111(2):14. doi: 10.1007/s00395-016-0530-0. Epub 2016 Jan 23.

9.

Differential Expression Levels of Integrin α6 Enable the Selective Identification and Isolation of Atrial and Ventricular Cardiomyocytes.

Wiencierz AM, Kernbach M, Ecklebe J, Monnerat G, Tomiuk S, Raulf A, Christalla P, Malan D, Hesse M, Bosio A, Fleischmann BK, Eckardt D.

PLoS One. 2015 Nov 30;10(11):e0143538. doi: 10.1371/journal.pone.0143538. eCollection 2015.

10.

Integrin Based Isolation Enables Purification of Murine Lineage Committed Cardiomyocytes.

Tarnawski L, Xian X, Monnerat G, Macaulay IC, Malan D, Borgman A, Wu SM, Fleischmann BK, Jovinge S.

PLoS One. 2015 Aug 31;10(8):e0135880. doi: 10.1371/journal.pone.0135880. eCollection 2015.

11.

Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy.

Friedrichs S, Malan D, Voss Y, Sasse P.

J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102.

12.

Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B.

Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964.

13.

Systemic gene transfer enables optogenetic pacing of mouse hearts.

Vogt CC, Bruegmann T, Malan D, Ottersbach A, Roell W, Fleischmann BK, Sasse P.

Cardiovasc Res. 2015 May 1;106(2):338-43. doi: 10.1093/cvr/cvv004. Epub 2015 Jan 12.

PMID:
25587047
14.

Human Connexin43E42K mutation from a sudden infant death victim leads to impaired ventricular activation and neonatal death in mice.

Lübkemeier I, Bosen F, Kim JS, Sasse P, Malan D, Fleischmann BK, Willecke K.

Circ Cardiovasc Genet. 2015 Feb;8(1):21-9. doi: 10.1161/CIRCGENETICS.114.000793. Epub 2014 Dec 10.

PMID:
25504652
15.

MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization.

Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T, Boettger T.

PLoS One. 2014 Nov 21;9(11):e113449. doi: 10.1371/journal.pone.0113449. eCollection 2014.

16.

Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling.

Kadari A, Mekala S, Wagner N, Malan D, Köth J, Doll K, Stappert L, Eckert D, Peitz M, Matthes J, Sasse P, Herzig S, Brüstle O, Ergün S, Edenhofer F.

Stem Cell Rev. 2015 Aug;11(4):560-9. doi: 10.1007/s12015-014-9564-6.

17.

FACS-based isolation, propagation and characterization of mouse embryonic cardiomyocytes based on VCAM-1 surface marker expression.

Pontén A, Walsh S, Malan D, Xian X, Schéele S, Tarnawski L, Fleischmann BK, Jovinge S.

PLoS One. 2013 Dec 30;8(12):e82403. doi: 10.1371/journal.pone.0082403. eCollection 2013.

18.

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system.

Becker N, Stoelzle S, Göpel S, Guinot D, Mumm P, Haarmann C, Malan D, Bohlen H, Kossolov E, Kettenhofen R, George M, Fertig N, Brüggemann A.

J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):82-7. doi: 10.1016/j.vascn.2013.03.009. Epub 2013 Apr 6.

PMID:
23567076
19.

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.

Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K.

Basic Res Cardiol. 2013 May;108(3):348. doi: 10.1007/s00395-013-0348-y. Epub 2013 Apr 5.

20.

Ultrasound-mediated stimulation of microbubbles after acute myocardial infarction and reperfusion ameliorates left-ventricular remodelling in mice via improvement of borderzone vascularization.

Dörner J, Struck R, Zimmer S, Peigney C, Duerr GD, Dewald O, Kim SC, Malan D, Bettinger T, Nickenig G, Ghanem A.

PLoS One. 2013;8(2):e56841. doi: 10.1371/journal.pone.0056841. Epub 2013 Feb 20.

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