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CDK4/CDK6 inhibition as a novel strategy to suppress the growth and survival of BCR-ABL1T315I+ clones in TKI-resistant CML.

Schneeweiss-Gleixner M, Byrgazov K, Stefanzl G, Berger D, Eisenwort G, Lucini CB, Herndlhofer S, Preuner S, Obrova K, Pusic P, Witzeneder N, Greiner G, Hoermann G, Sperr WR, Lion T, Deininger M, Valent P, Gleixner KV.

EBioMedicine. 2019 Nov 21. pii: S2352-3964(19)30745-5. doi: 10.1016/j.ebiom.2019.11.004. [Epub ahead of print]


Physicochemical and Biological Properties of Gelatin Extracted from Marine Snail Rapana venosa.

Gaspar-Pintiliescu A, Stefan LM, Anton ED, Berger D, Matei C, Negreanu-Pirjol T, Moldovan L.

Mar Drugs. 2019 Oct 17;17(10). pii: E589. doi: 10.3390/md17100589.


Polyphenols extract from grape pomace. Characterization and valorisation through encapsulation into mesoporous silica-type matrices.

Brezoiu AM, Matei C, Deaconu M, Stanciuc AM, Trifan A, Gaspar-Pintiliescu A, Berger D.

Food Chem Toxicol. 2019 Nov;133:110787. doi: 10.1016/j.fct.2019.110787. Epub 2019 Aug 23.


Identification of a leukemia-initiating stem cell in human mast cell leukemia.

Eisenwort G, Sadovnik I, Schwaab J, Jawhar M, Keller A, Stefanzl G, Berger D, Blatt K, Hoermann G, Bilban M, Willmann M, Winding C, Sperr WR, Arock M, Rülicke T, Reiter A, Valent P.

Leukemia. 2019 Nov;33(11):2673-2684. doi: 10.1038/s41375-019-0460-6. Epub 2019 Apr 5.


A kinase profile-adapted drug combination elicits synergistic cooperative effects on leukemic cells carrying BCR-ABL1T315I in Ph+ CML.

Gleixner KV, Sadovnik I, Schneeweiss M, Eisenwort G, Byrgazov K, Stefanzl G, Berger D, Herrmann H, Hadzijusufovic E, Lion T, Valent P.

Leuk Res. 2019 Mar;78:36-44. doi: 10.1016/j.leukres.2018.12.013. Epub 2018 Dec 28.


Oral Biofilms: Development, Control, and Analysis.

Berger D, Rakhamimova A, Pollack A, Loewy Z.

High Throughput. 2018 Aug 31;7(3). pii: E24. doi: 10.3390/ht7030024. Review.


CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.

Mueller N, Wicklein D, Eisenwort G, Jawhar M, Berger D, Stefanzl G, Greiner G, Boehm A, Kornauth C, Muellauer L, Sehner S, Hoermann G, Sperr WR, Staber PB, Jaeger U, Zuber J, Arock M, Schumacher U, Reiter A, Valent P.

Blood. 2018 Nov 1;132(18):1936-1950. doi: 10.1182/blood-2018-02-833582. Epub 2018 Jul 17.


Hitting two oncogenic machineries in cancer cells: cooperative effects of the multi-kinase inhibitor ponatinib and the BET bromodomain blockers JQ1 or dBET1 on human carcinoma cells.

Bauer K, Berger D, Zielinski CC, Valent P, Grunt TW.

Oncotarget. 2018 May 29;9(41):26491-26506. doi: 10.18632/oncotarget.25474. eCollection 2018 May 29.


Phenotyping and Target Expression Profiling of CD34+/CD38- and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia.

Blatt K, Menzl I, Eisenwort G, Cerny-Reiterer S, Herrmann H, Herndlhofer S, Stefanzl G, Sadovnik I, Berger D, Keller A, Hauswirth A, Hoermann G, Willmann M, Rülicke T, Sill H, Sperr WR, Mannhalter C, Melo JV, Jäger U, Sexl V, Valent P.

Neoplasia. 2018 Jun;20(6):632-642. doi: 10.1016/j.neo.2018.04.004. Epub 2018 May 15.


Controlling drug release from mesoporous silica through an amorphous, nanoconfined 1-tetradecanol layer.

Mitran RA, Matei C, Berger D, Băjenaru L, Moisescu MG.

Eur J Pharm Biopharm. 2018 Jun;127:318-325. doi: 10.1016/j.ejpb.2018.02.020. Epub 2018 Mar 7.


The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosis.

Schneeweiss M, Peter B, Bibi S, Eisenwort G, Smiljkovic D, Blatt K, Jawhar M, Berger D, Stefanzl G, Herndlhofer S, Greiner G, Hoermann G, Hadzijusufovic E, Gleixner KV, Bettelheim P, Geissler K, Sperr WR, Reiter A, Arock M, Valent P.

Haematologica. 2018 May;103(5):799-809. doi: 10.3324/haematol.2017.179895. Epub 2018 Feb 8.


Evaluation of cooperative antileukemic effects of nilotinib and vildagliptin in Ph+ chronic myeloid leukemia.

Willmann M, Sadovnik I, Eisenwort G, Entner M, Bernthaler T, Stefanzl G, Hadzijusufovic E, Berger D, Herrmann H, Hoermann G, Valent P, Rülicke T.

Exp Hematol. 2018 Jan;57:50-59.e6. doi: 10.1016/j.exphem.2017.09.012. Epub 2017 Oct 12.


The pan-BCL-2-blocker obatoclax (GX15-070) and the PI3-kinase/mTOR-inhibitor BEZ235 produce cooperative growth-inhibitory effects in ALL cells.

Stefanzl G, Berger D, Cerny-Reiterer S, Blatt K, Eisenwort G, Sperr WR, Hoermann G, Lind K, Hauswirth AW, Bettelheim P, Sill H, Melo JV, Jäger U, Valent P.

Oncotarget. 2017 Jun 28;8(40):67709-67722. doi: 10.18632/oncotarget.18810. eCollection 2017 Sep 15.


Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia.

Gleixner KV, Schneeweiss M, Eisenwort G, Berger D, Herrmann H, Blatt K, Greiner G, Byrgazov K, Hoermann G, Konopleva M, Waliul I, Cumaraswamy AA, Gunning PT, Maeda H, Moriggl R, Deininger M, Lion T, Andreeff M, Valent P.

Haematologica. 2017 Sep;102(9):1519-1529. doi: 10.3324/haematol.2016.163436. Epub 2017 Jun 8.


The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma.

Keller A, Wingelhofer B, Peter B, Bauer K, Berger D, Gamperl S, Reifinger M, Cerny-Reiterer S, Moriggl R, Willmann M, Valent P, Hadzijusufovic E.

Vet Comp Oncol. 2018 Mar;16(1):55-68. doi: 10.1111/vco.12311. Epub 2017 Apr 11. Erratum in: Vet Comp Oncol. 2019 Sep;17(3):446-447.


Box-Behnken experimental design for chromium(VI) ions removal by bacterial cellulose-magnetite composites.

Stoica-Guzun A, Stroescu M, Jinga SI, Mihalache N, Botez A, Matei C, Berger D, Damian CM, Ionita V.

Int J Biol Macromol. 2016 Oct;91:1062-72. doi: 10.1016/j.ijbiomac.2016.06.070. Epub 2016 Jun 22.


The Validation of a Spanish Version of the Multidimensional Inventory of Religious/Spiritual Well-Being in Mexican College Students.

Berger D, Fink A, Perez Gomez MM, Lewis A, Unterrainer HF.

Span J Psychol. 2016 Feb 18;19:E3. doi: 10.1017/sjp.2016.9.


Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML.

Sadovnik I, Hoelbl-Kovacic A, Herrmann H, Eisenwort G, Cerny-Reiterer S, Warsch W, Hoermann G, Greiner G, Blatt K, Peter B, Stefanzl G, Berger D, Bilban M, Herndlhofer S, Sill H, Sperr WR, Streubel B, Mannhalter C, Holyoake TL, Sexl V, Valent P.

Clin Cancer Res. 2016 Apr 15;22(8):2051-61. doi: 10.1158/1078-0432.CCR-15-0767. Epub 2015 Nov 25.


Correlation of the intracellular reactive oxygen species levels with textural properties of functionalized mesostructured silica.

Bajenaru L, Berger D, Miclea L, Matei C, Nastase S, Andronescu C, Moisescu MG, Savopol T.

J Biomed Mater Res A. 2014 Dec;102(12):4435-42. doi: 10.1002/jbm.a.35131. Epub 2014 Feb 25.


Type 1 fimbriae contribute to catheter-associated urinary tract infections caused by Escherichia coli.

Reisner A, Maierl M, Jörger M, Krause R, Berger D, Haid A, Tesic D, Zechner EL.

J Bacteriol. 2014 Mar;196(5):931-9. doi: 10.1128/JB.00985-13. Epub 2013 Dec 13.

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