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Items: 1 to 20 of 171

1.

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors.

Svobodova B, Mezeiova E, Hepnarova V, Hrabinova M, Muckova L, Kobrlova T, Jun D, Soukup O, Jimeno ML, Marco-Contelles J, Korabecny J.

Biomolecules. 2019 Aug 19;9(8). pii: E379. doi: 10.3390/biom9080379.

PMID:
31430943
2.

Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease.

Hulcová D, Maříková J, Korábečný J, Hošťálková A, Jun D, Kuneš J, Chlebek J, Opletal L, De Simone A, Nováková L, Andrisano V, Růžička A, Cahlíková L.

Phytochemistry. 2019 Sep;165:112055. doi: 10.1016/j.phytochem.2019.112055. Epub 2019 Jun 28.

PMID:
31261031
3.

Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase.

de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, França TCC.

Chem Biol Interact. 2019 Aug 1;308:113-119. doi: 10.1016/j.cbi.2019.05.022. Epub 2019 May 14.

PMID:
31100275
4.

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier.

Chlebek J, Korábečný J, Doležal R, Štěpánková Š, Pérez DI, Hošťálková A, Opletal L, Cahlíková L, Macáková K, Kučera T, Hrabinová M, Jun D.

Molecules. 2019 Apr 5;24(7). pii: E1340. doi: 10.3390/molecules24071340.

5.

N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy.

Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J, Pham NL, Nguyen TD, Valis M, Kuca K.

Curr Alzheimer Res. 2019;16(4):333-343. doi: 10.2174/1567205016666190314163942.

PMID:
30873921
6.

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K.

Eur J Med Chem. 2019 Apr 15;168:491-514. doi: 10.1016/j.ejmech.2019.02.021. Epub 2019 Feb 27.

PMID:
30851693
7.

Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.

Hostalkova A, Marikova J, Opletal L, Korabecny J, Hulcova D, Kunes J, Novakova L, Perez DI, Jun D, Kucera T, Andrisano V, Siatka T, Cahlikova L.

J Nat Prod. 2019 Feb 22;82(2):239-248. doi: 10.1021/acs.jnatprod.8b00592. Epub 2019 Jan 31.

PMID:
30701972
8.

Oxime K203: a drug candidate for the treatment of tabun intoxication.

Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J.

Arch Toxicol. 2019 Mar;93(3):673-691. doi: 10.1007/s00204-018-2377-7. Epub 2018 Dec 18.

PMID:
30564897
9.

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

Dgachi Y, Martin H, Malek R, Jun D, Janockova J, Sepsova V, Soukup O, Iriepa I, Moraleda I, Maalej E, Carreiras MC, Refouvelet B, Chabchoub F, Marco-Contelles J, Ismaili L.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):163-170. doi: 10.1080/14756366.2018.1538136.

10.

Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.

Pospisilova M, Andrs M, Seifrtova M, Havelek R, Jun D, Tomsik P, Prchal L, Dolezal R, Tichy A, Kucera T, Korabecny J, Rezacova M.

Bioorg Chem. 2019 Feb;82:204-210. doi: 10.1016/j.bioorg.2018.10.001. Epub 2018 Oct 6.

PMID:
30326402
11.

Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS).

de Almeida JSFD, Dolezal R, Krejcar O, Kuca K, Musilek K, Jun D, França TCC.

Toxins (Basel). 2018 Sep 25;10(10). pii: E389. doi: 10.3390/toxins10100389.

12.

Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study.

Malinak D, Nepovimova E, Jun D, Musilek K, Kuca K.

Molecules. 2018 Sep 7;23(9). pii: E2291. doi: 10.3390/molecules23092291.

13.

Outcomes of underweight, overweight, and obese pediatric kidney transplant recipients.

Kaur K, Jun D, Grodstein E, Singer P, Castellanos L, Teperman L, Molmenti E, Fahmy A, Frank R, Infante L, Sethna CB.

Pediatr Nephrol. 2018 Dec;33(12):2353-2362. doi: 10.1007/s00467-018-4038-8. Epub 2018 Aug 22.

PMID:
30136105
14.

The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution.

Carlson ML, Young JW, Zhao Z, Fabre L, Jun D, Li J, Li J, Dhupar HS, Wason I, Mills AT, Beatty JT, Klassen JS, Rouiller I, Duong F.

Elife. 2018 Aug 15;7. pii: e34085. doi: 10.7554/eLife.34085.

15.

Purin-6-one and pyrrolo[2,3-d]pyrimidin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.

Andrs M, Pospisilova M, Seifrtova M, Havelek R, Tichy A, Vejrychova K, Polednikova M, Gorecki L, Jun D, Korabecny J, Rezacova M.

Future Med Chem. 2018 Sep 1;10(17):2029-2038. doi: 10.4155/fmc-2018-0086. Epub 2018 Aug 1.

PMID:
30067076
16.

Simultaneous determination of malondialdehyde and 3-nitrotyrosine in cultured human hepatoma cells by liquid chromatography-mass spectrometry.

Vanova N, Muckova L, Schmidt M, Herman D, Dlabkova A, Pejchal J, Jun D.

Biomed Chromatogr. 2018 Dec;32(12):e4349. doi: 10.1002/bmc.4349. Epub 2018 Aug 21.

PMID:
30051494
17.

Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.

Hamulakova S, Janovec L, Soukup O, Jun D, Janockova J, Hrabinova M, Sepsova V, Kuca K.

Curr Alzheimer Res. 2018;15(12):1096-1105. doi: 10.2174/1567205015666180711110750.

PMID:
29992880
18.

Vector Control and Insecticidal Resistance in the African Malaria Mosquito Anopheles gambiae.

Schmidt M, Hrabcova V, Jun D, Kuca K, Musilek K.

Chem Res Toxicol. 2018 Jul 16;31(7):534-547. doi: 10.1021/acs.chemrestox.7b00285. Epub 2018 Jun 15. Review.

PMID:
29847927
19.

Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site of human acetylcholinesterase.

de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, França TCC.

J Biomol Struct Dyn. 2019 May;37(8):2041-2048. doi: 10.1080/07391102.2018.1475259. Epub 2018 Nov 2.

PMID:
29749305
20.

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon.

Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q, Nepovimova E, França TCC.

Molecules. 2018 May 7;23(5). pii: E1103. doi: 10.3390/molecules23051103.

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