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Items: 1 to 20 of 45

1.

Steroid diversification by multicomponent reactions.

Reguera L, Attorresi CI, Ramírez JA, Rivera DG.

Beilstein J Org Chem. 2019 Jun 6;15:1236-1256. doi: 10.3762/bjoc.15.121. eCollection 2019. Review.

2.

Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis.

de la Torre AF, Scatena GS, Valdés O, Rivera DG, Paixão MW.

Beilstein J Org Chem. 2019 Jun 4;15:1210-1216. doi: 10.3762/bjoc.15.118. eCollection 2019.

3.

Multicomponent Reaction Toolbox for Peptide Macrocyclization and Stapling.

Reguera L, Rivera DG.

Chem Rev. 2019 Apr 16. doi: 10.1021/acs.chemrev.8b00744. [Epub ahead of print]

PMID:
30990310
4.

Introducing the Petasis Reaction for Late-Stage Multicomponent Diversification, Labeling, and Stapling of Peptides.

Ricardo MG, Llanes D, Wessjohann LA, Rivera DG.

Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2700-2704. doi: 10.1002/anie.201812620. Epub 2019 Jan 25.

PMID:
30589179
5.

A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge.

Vasco AV, Méndez Y, Porzel A, Balbach J, Wessjohann LA, Rivera DG.

Bioconjug Chem. 2019 Jan 16;30(1):253-259. doi: 10.1021/acs.bioconjchem.8b00906. Epub 2019 Jan 7.

PMID:
30575393
6.

Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics.

Méndez Y, De Armas G, Pérez I, Rojas T, Valdés-Tresanco ME, Izquierdo M, Alonso Del Rivero M, Álvarez-Ginarte YM, Valiente PA, Soto C, de León L, Vasco AV, Scott WL, Westermann B, González-Bacerio J, Rivera DG.

Eur J Med Chem. 2019 Feb 1;163:481-499. doi: 10.1016/j.ejmech.2018.11.074. Epub 2018 Dec 1.

PMID:
30544037
7.

A Peptide Backbone Stapling Strategy Enabled by the Multicomponent Incorporation of Amide N-Substituents.

Ricardo MG, Marrrero JF, Valdés O, Rivera DG, Wessjohann LA.

Chemistry. 2019 Jan 14;25(3):769-774. doi: 10.1002/chem.201805318. Epub 2018 Dec 13.

PMID:
30412333
8.

A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives.

Echemendía R, da Silva GP, Kawamura MY, de la Torre AF, Corrêa AG, Ferreira MAB, Rivera DG, Paixão MW.

Chem Commun (Camb). 2019 Jan 2;55(3):286-289. doi: 10.1039/c8cc06871b.

PMID:
30411110
9.

Diversity Driven Decoration and Ligation of Fullerene by Ugi and Passerini Multicomponent Reactions.

Ravanello BB, Seixas N, Rodrigues OED, da Silva RS, Villetti MA, Frolov A, Rivera DG, Westermann B.

Chemistry. 2018 Jul 11;24(39):9788-9793. doi: 10.1002/chem.201802414. Epub 2018 Jun 8.

PMID:
29882608
10.

Multicomponent Reactions in Ligation and Bioconjugation Chemistry.

Reguera L, Méndez Y, Humpierre AR, Valdés O, Rivera DG.

Acc Chem Res. 2018 Jun 19;51(6):1475-1486. doi: 10.1021/acs.accounts.8b00126. Epub 2018 May 25.

PMID:
29799718
11.

Multicomponent polysaccharide-protein bioconjugation in the development of antibacterial glycoconjugate vaccine candidates.

Méndez Y, Chang J, Humpierre AR, Zanuy A, Garrido R, Vasco AV, Pedroso J, Santana D, Rodríguez LM, García-Rivera D, Valdés Y, Vérez-Bencomo V, Rivera DG.

Chem Sci. 2018 Jan 19;9(9):2581-2588. doi: 10.1039/c7sc05467j. eCollection 2018 Mar 7.

12.

KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.

González-Bacerio J, Maluf SEC, Méndez Y, Pascual I, Florent I, Melo PMS, Budu A, Ferreira JC, Moreno E, Carmona AK, Rivera DG, Alonso Del Rivero M, Gazarini ML.

Bioorg Med Chem. 2017 Sep 1;25(17):4628-4636. doi: 10.1016/j.bmc.2017.06.047. Epub 2017 Jul 4.

PMID:
28728898
13.

Peptide Macrocyclization Assisted by Traceless Turn Inducers Derived from Ugi Peptide Ligation with Cleavable and Resin-Linked Amines.

Puentes AR, Morejón MC, Rivera DG, Wessjohann LA.

Org Lett. 2017 Aug 4;19(15):4022-4025. doi: 10.1021/acs.orglett.7b01761. Epub 2017 Jul 13.

PMID:
28704057
14.

A multicomponent macrocyclization strategy to natural product-like cyclic lipopeptides: synthesis and anticancer evaluation of surfactin and mycosubtilin analogues.

Morejón MC, Laub A, Kaluđerović GN, Puentes AR, Hmedat AN, Otero-González AJ, Rivera DG, Wessjohann LA.

Org Biomol Chem. 2017 May 3;15(17):3628-3637. doi: 10.1039/c7ob00459a.

PMID:
28406518
15.

One-Pot Assembly of Amino Acid Bridged Hybrid Macromulticyclic Cages through Multiple Multicomponent Macrocyclizations.

Wessjohann LA, Kreye O, Rivera DG.

Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3501-3505. doi: 10.1002/anie.201610801. Epub 2017 Feb 17.

PMID:
28211208
16.

Solution- and Solid-Phase Macrocyclization of Peptides by the Ugi-Smiles Multicomponent Reaction: Synthesis of N-Aryl-Bridged Cyclic Lipopeptides.

Morejón MC, Laub A, Westermann B, Rivera DG, Wessjohann LA.

Org Lett. 2016 Aug 19;18(16):4096-9. doi: 10.1021/acs.orglett.6b02001. Epub 2016 Aug 9.

PMID:
27505031
17.

Applications of Convertible Isonitriles in the Ligation and Macrocyclization of Multicomponent Reaction-Derived Peptides and Depsipeptides.

Wessjohann LA, Morejón MC, Ojeda GM, Rhoden CR, Rivera DG.

J Org Chem. 2016 Aug 5;81(15):6535-45. doi: 10.1021/acs.joc.6b01150. Epub 2016 Jul 14.

PMID:
27390908
18.

Multicomponent Synthesis of Cyclic Depsipeptide Mimics by Ugi Reaction Including Cyclic Hemiacetals Derived from Asymmetric Organocatalysis.

de la Torre AF, Rivera DG, Concepción O, Echemendia R, Correa AG, Paixão MW.

J Org Chem. 2016 Feb 5;81(3):803-9. doi: 10.1021/acs.joc.5b02158. Epub 2016 Jan 14.

PMID:
26720907
19.

Macrocyclization of Peptide Side Chains by the Ugi Reaction: Achieving Peptide Folding and Exocyclic N-Functionalization in One Shot.

Vasco AV, Pérez CS, Morales FE, Garay HE, Vasilev D, Gavín JA, Wessjohann LA, Rivera DG.

J Org Chem. 2015 Jul 2;80(13):6697-707. doi: 10.1021/acs.joc.5b00858. Epub 2015 Jun 17.

PMID:
26030840
20.

Aminocatalysis-Mediated on-Resin Ugi Reactions: Application in the Solid-Phase Synthesis of N-Substituted and Tetrazolo Lipopeptides and Peptidosteroids.

Morales FE, Garay HE, Muñoz DF, Augusto YE, Otero-González AJ, Reyes Acosta O, Rivera DG.

Org Lett. 2015 Jun 5;17(11):2728-31. doi: 10.1021/acs.orglett.5b01147. Epub 2015 May 21.

PMID:
25994574

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