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Front Aging Neurosci. 2017 May 18;9:146. doi: 10.3389/fnagi.2017.00146. eCollection 2017.

Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images.

Collaborators (3368)

Hariharan A, Vijayakumari AA, Aarabi MH, Aballi J, Nour AEAAM, Abdelaziz M, Abdolalizadeh A, Abdollahi M, Abdul Aziz SA, Salam AA, Abdulaziz N, Abdulkadir A, Abdullah S, Abdullah O, Abrigo J, Adachi N, Adamson C, Adduru V, Adduru V, Adel T, Aderghal K, Ades-Aron B, Adeyosoye M, Adlard P, Srinivasa A, Aganj I, Agarwal A, Agarwal A, Agarwal A, Aguero C, Aguiar P, Ahdidan J, Ahmad F, Ahmad R, Ahmadi H, Ahmed N, Sid FA, Ai E, Ai Q, Aicha B, Aitharaju S, Aiyer A, Akkus Z, Akodad S, Akramifard H, Aksman L, Aktas S, Al-Janabi O, Al-Nuaimi A, AlAila B, Alakwaa F, Alam S, Alam F, Alam Zaidi SF, Alan W, Alansari M, Alareqi E, Alberdi A, Albsoul M, Alderson T, Aleem H, Alex A, Alexander J, Alexopoulos P, Alfoldi J, Ali A, Ali I, Alimoradian S, Aljabar P, Aljabbouli H, Aljovic A, Allen G, Alliende LM, Almaguel F, Almgren H, Montes CA, Alowaisheq T, Alryalat SA, Alsado M, Alsaedi A, Alshehri H, Altaf T, Altendahl M, Altmann A, Alvand A, Filho MA, Alzubi R, Amaral R, Ambatipudi M, Amernath R, Amlien I, Amoroso N, Amri H, Anastasiou A, Anbarasi J, Anbarjafari G, Anderson W, Anderson J, Anderson V, Anderson L, Andonov J, Andova V, Andreopoulou I, Andrews KA, Andrews C, Angeles M, Anne-Laure A, Ansari GJ, Ansari S, Anstey K, Antunes A, Aoshuang Z, Aouf M, Aow Yong LY, Aporntewan C, Apostolova L, Appiah F, Apsvalka D, Arab A, Araque Caballero MÁ, Arbabyazd M, Arbelaez P, Archer K, Ardekani B, Aretouli E, Arfanakis K, Arisi I, Armentrout S, Arnold M, Arnold S, Arnold S, Arslan S, Artacho-Perula E, Arthofer C, Aruchamy S, Arya Z, Pizarro CA, Ashford W, Ashraf A, Askland K, Aslaksen P, Aslakson E, Aso T, Astphan M, Ataloglou D, Atay M, Athanas A, Atri R, Au A, Aurich M, Avants B, Awasthi N, Awate S, Ayaz A, Son YA, Aydogan DB, Ayhan M, Ayton S, Aziz A, Azmi MH, Ba M, Bach K, Badea A, Bag A, Bagewadi S, Bai X, Bai Z, Bai H, Baird G, Baiwen Z, Baker E, Baker J, Bakker A, Ball E, Ballén Galindo MÁ, Banaei A, Bandyopadhyay D, Bang KH, Bangen K, Banks S, Banning L, Bao WY, Barakat R, Barbará E, Barber P, Barber R, De Araujo FRB, Barnes J, Barredo J, Barret O, Barrett M, Barsamian B, Barsky A, Bartel F, Bartoszewicz J, Bartram-Shaw D, Barwood C, Basavaraj S, Basavaraj A, Basiouny A, Baskaran B, Basu A, Baths V, Bathula D, Batmanghelich NK, Bauer R, Bauer C, Bawa V, Bayley P, Bayram A, Bazi Y, Beach T, Beaudoin K, Beaulieu C, Becker C, Beckett L, Bedding A, Beer S, Beer J, Beg MF, Beg MF, Behfar Q, Behjat H, Behjat H, Behseta S, Bekris L, Suresh MB, Belichenko N, Bellio M, Belyaev M, Bemiller S, Ahmed OB, Ben Bouallègue F, Benedikt M, Benge J, Benitez A, Benlloch JM, Benn M, Benyoussef EM, Bergeron D, Bermudez E, Bessadok A, Betzel R, Bezuidenhoudt M, Bhagwat N, Bhalerao S, Bhandari A, Bhasin H, Bhati R, Bhatkoti P, Bhatt P, Bhatt P, Bhattacharjee D, Bhattacharyya S, Bi R, Bi J, Bi H, Biancardi A, Bidart R, Bilgel M, Billiet T, Binczyk F, Bingsheng H, Bird C, Bischof G, Bishnoi R, Biswas S, Bjelke D, Black S, Blackwood J, Blaese E, Blair J, Blanchard G, Bloom T, Blujus J, Blusztajn JK, Bo W, Bo J, Boda R, Boellaard R, Bogorodzki P, Bokde A, Bolhasani E, Bonakdarpour B, Bonazzoli M, Bône A, Borkowsky J, Borrajo D, Bos I, Bosco P, Bott N, Rodrigues RBML, Boughanmi A, Bougias H, Boulier T, Bourgeat P, Bouyagoub S, Bowes M, Boyes R, Bozoki A, Bradshaw T, Pereira JB, Brahami Y, Brambati SM, Bras J, Braskie M, Brecheisen R, Bregman N, Brewer J, Briassouli A, Brickman A, Bridges R, Brihmat N, Brinkmann B, Britschgi M, Broers T, Bron E, Brown J, Brown M, Brown A, Brown M, Brunberg J, Bu T, Bubbico G, Bubenik P, Bubu O, Buchanan D, Buchholz HG, Buchsbaum B, Buck K, Buckley R, Budgeon C, Buhl D, Sánchez MB, Bundela S, Bundela S, Burciu I, Burgos N, Burke S, Burn K, Burns J, Burns G, Burzykowski T, Bush S, Buss S, Butcher B, Butt V, Buxbaum J, Sandeep CS, Cabrera C, Cahyaningrum W, Cai ZN, Cai S, Cai E, Cajka T, Calamia M, Caligiuri ME, Calixte C, Calon F, Cameron B, Campbell R, Campbell R, Lopez JAC, Cao H, Cao J, Cao G, Cao B, Capizzano A, Capon D, Carmasin J, Carmichael O, Carr S, Carrier J, Carter G, Carvalho L, Carvalho J, Carvalho C, Casamitjana A, Casanova R, Casas JR, Cash D, Castelluccio P, Castiglioni I, Caswell C, Cattell L, Cauda F, Cepeda I, Çevik A, Cha J, Chakrabarti S, Chakraborty S, Chammam T, Chan C, Chand G, Chang C, Chang YM, Chang R, Chang H, Chang YC, Chang KJ, Chang CW, Chantrel S, Chao J, Chao L, Chapleau M, Charil A, Chatterjee P, Chatterjee S, Chaudhry Z, Chauhan H, Chehade A, Chekuri O, Cheloshkina K, Chen J, Chen G, Chen G, Chen TH, Chen YJ, Chen X, Chen TC, Chen G, Chen S, Chen J, Chen F, Chen K, Chen G, Chen J, Chen G, Chen YH, Chen MH, Chen C, Chen SY, Chen HH, Chen X, Chen K, Chen Y, Chen H, Chen R, Chen IJ, Chen X, Chen J, Chen J, Chen B, Cheng D, Cheng H, Cheng Y, Cheng Y, Cheng Z, Cheng WH, Chenhall T, Chepkoech JL, Cherukuri V, Chhibber A, Chi H, Chi CL, Chiang G, Chiesa P, Childress DM, Chilukuri Y, Fatt CC, Chincarini A, Ching C, Chiotis K, Cho SH, Cho Y, Cho S, Choi JS, Choi H, Choi Y, Choi S, Choi J, Choi E, Choo ILH, Chopra V, Chougrad H, Chouraki V, Christini A, Chu Y, Chuang TC, Chuanji L, Chuanjian Y, Chun M, Chun S, Chung A, Chung YM, Chung JC, Chung AW, Chung J, Chyzhyk D, Ciarleglio A, Cioli C, Cittanti C, Cives A, Clark M, Clayton D, Clement M, Clifft D, Climer S, Clouston S, Clunie D, Cohen P, Cohen T, Cole M, Cole J, Colletti P, Collingwood J, Comley R, Conklin B, Conner L, Conover J, Contardo-Berning I, Conway R, Copani A, Coppola G, Corbett S, Corlier F, Correia R, Cosman J, Costantino S, Costantino S, Coubard O, Coulson E, Couser E, Cox K, Coyle P, Cozzi B, Craddock C, Crawford K, Crawford K, Creese B, Cribben I, Crisostomo-Wynne T, Crossley N, Croteau E, Cruchaga C, Cuajungco M, Cui J, Cui S, Cullen N, Cuneo D, Cutanda V, Cynader M, Binu D, D'Avossa G, Dai T, Dai P, Dai H, Davied Hong DH, Dakovic M, Dalca A, Damiani S, Dammak M, Damoiseaux J, Dan Z, Dang XH, Dang S, Daniel Z, Danjou F, Darby E, Darby R, Dardzinska A, Darst B, Darvesh S, Das K, Das D, Das S, Das D, Datta S, Dauvillier J, Davatzikos C, Davidson I, De Boer R, De Bruijne M, De Buhan M, De Jager P, De La Concha Vega N, De Lange S, De Luis Garcia R, De Marco M, De Sitter A, Dean S, DeCarli C, Decker S, Del Gaizo J, Demir Z, Denby C, Deng Y, Deng W, Denisova K, Denney W, Depue B, DeRamus T, Desikan R, Desplats P, Desrosiers C, Devadas V, Devanarayan V, Devarajan S, Devenyi G, Dezhina Z, Dhami D, Dharsee M, Dhillon P, Di X, Di Mauro N, Diah K, Diamond S, Diaz-Asper C, Diciotti S, Dickerson B, Dickie DA, Dickinson P, Dicks E, Diedrich K, Dieumegarde L, Dill V, Dilliott A, Ding Z, Ding S, Ding Y, Ding X, Ding X, Dinov I, Dinu V, Diouf I, Dmitriev P, Dobromyslin V, Dodge H, Dodge H, Dolui S, Dona O, Dondelinger F, Dong W, Dong HM, Kehoe PD, Donohue M, Dore V, Dougherty C, Doughty M, Dowling NM, Doyle S, Doyle A, Dragan M, Draganski B, Draghici S, Dragomir A, Drake D, Drake E, Drd S, Dronkers N, Drozdowski M, Du C, Du Y, Du L, Du G, Du X, Du C, Duan F, Duan Y, Duan K, Duchesne S, Duchesne S, Duggento A, Dukart J, Dumont M, Dunn R, Duong V, Duraisamy B, Duran T, Durrleman S, Dutta J, Dyrba M, Dyvorne H, R AE, Eads J, Eastman J, Eaton S, Edlund C, Edmonds E, Edmondson M, Ehsan F, El-Gabalawy F, Elander A, Elander A, Elango VE, Eldeeb G, Elgamal F, Rodrigues YE, Elman J, Elrakaiby N, Emahazion T, Emami B, Embrechts J, Emran Khan Emon MA, Emrani S, Emrani A, Emri M, Engelhardt B, Engle B, Epstein N, Er F, Erhardt E, Eriksson O, Omay ZE, Escudero J, Eshleman J, Eskildsen S, Espinosa L, Essex R, Esteban O, Estrada K, Ethell D, Ethridge K, Ettehadi S, Eva B, Evenden D, Evtikheeve R, Ewert S, Fague S, Fahmi R, Faizal S, Falahati F, Fan L, Fan Z, Fan Y, Fan M, Fan Y, Fan S, Fan Z, Fan R, Fang C, Fang X, Fanjul-Vélez F, Fanti A, Far B, Farah M, Farahani N, Farahibozorg S, Farahnak F, Farajpour M, Fardo D, Farkhani S, Farnsworth B, Farooq H, Farooq A, Farouk Y, Farrar D, Farrer L, Fatemehh F, Fatemizadeh E, Fatfat K, Fatima S, Faux N, Favan-Niven A, Favary C, Fazlollahi A, Fei G, Feingold F, Feizi S, Félix E, Femminella GD, Feng Z, Feng A, Feng B, Feng X, Feng Z, Feragen A, Fereidouni M, Fernandes M, Fernández V, Ferrari R, Ferraris S, Ferreira F, Ferreira LK, Ferreira H, Fiecas M, Fieremans E, Fiford C, Figurski M, Filippi M, Filshtein T, Findley C, Finger E, Firth N, Fischer C, Fischer F, Fitall S, Fleet B, Fleishman G, Flokas L, Flores A, Focke N, Fok WY, Foldi N, Fôlego G, Forero A, Fornage M, Fos Guarinos B, Founshtein G, Franc B, Francois C, Franke K, Fraser M, Frasier M, Frederick B, Freitas F, Escalin FJ, Freudenberg-Hua Y, Friedman B, Friedmann T, Friedrich CM, Frings L, Frisoni G, Fritzsche K, Frolov A, Frost R, Fu L, Fu Z, Fudao K, Fuentes E, Fuentes E, Fujishima M, Fujiwara K, Fukami T, Funk C, Furcila D, Fuselier J, Nagarjuna Reddy G, Gaasterland T, Gabelle A, Gahm J, Gaiteri C, Gajawelli N, Galantino A, Galarza Hernández J, Galasko D, Galea L, Galisot G, Sánchez AJG, Gallins P, Gamberger D, Gan HS, Gan G, Ganapathi S, Gancayco C, Gangishetti U, Ganzetti M, Gao F, Gao J, Gao L, Gao F, Gao L, Gao T, Gao Y, Gao X, Garani R, Garbarino S, Garcia I, Garcia X, Garcia J, Garcia T, Garcia Arias HF, De La Garza AG, Gaig MG, Novoa JG, Valero MG, Garcia-Ojalvo J, García-Polo P, Garg R, Garg G, Garg D, Garibotto V, Garvey M, Garza-Villarreal E, Gaubert M, Gauthier S, Gavett B, Gavidia G, Gavtash B, Gawryluk J, Gbah M, Ge T, Geerts H, Geisser N, Geng J, Gentili C, Gess F, Ghaderi H, Ghahari S, Ghanbari Y, Ghazi-Saidi L, Ghodrati M, Ghorbani B, Ghoreishiamiri R, Ghosal S, Ghosh S, Ghosh S, Ghosh S, Ghoshal A, Giannicola G, Gibert K, Gibson G, Gieschke R, Gil Valencia JM, Gillen D, Giordani A, Giraldo D, Gispert JD, Gitelman D, Giuffrida MV, Madhu GK, Glass J, Glazier B, Gleason C, Glerean E, Glozman T, Godbey M, Goettlich M, Gogoi M Dr, Gola K, Golbabaei S, Golden D, Goldstein F, Gomes C, De Olivera RGD, Gomez I, Gomez Gonzalez JP, Gomez-Verdejo V, Gong W, Gong E, Gong K, Gonneaud J, Gonzalez C, Gonzalez E, Gonzalez G, Moreira EG, Goodman J, Gopinath S, Gopu A, Gordon B, Gordon D, Gordon M, Gorriz JM, Gors D, Göttler J, Gounari X, Goyal D, Graf J, Graff A, Graham L, Graham J, Grajski K, Grami M, Grand'Maison M, Grant K, Grassi E, Gray K, Grecchi E, Green R, Green E, Greenberg J, Greening S, Greenwood B, Gregori J, Gregory M, Greicius M, Greve D, Griffin J, Grill J, Grodner K, Grolmusz V, Groot P, Groothuis I, Gross A, Grundstad A, Grundy E, Grzegorczyk T, Nandith GS, Gu D, Gu J, Gu J, Gu Y, Gu G, Guan S, Guan Y, Guennel T, Guerin L, Guerrero R, Guerrier L, Guevara P, Guggari S, Roy AG, Guidotti R, Guillon J, Gulcher J, Gulia S, Gumedze F, Gunawardena N, Gunn R, Guo M, Guo X, Guo X, Guo Y, Kai ZG, Zhao MG, Gupta N, Gupta A, Gupta I, Guren O, Gurnani A, Gurol ME, Guzman G, Gyy G, Rajanna VH, Ha S, Haacke E, Haaksma M, Habadi M, Habeck C, Habes M, Hackspiel Zarate MM, Hadimani R, Hahn W, Hahn T, Haight T, Hair N, Haixing W, Hajarolasvadi N, Hajjar I, Hajjo R, Halchenko Y, Hall A, Hallock K, Hamdi SM, Hameed F, Hamidian H, Han D, Han Y, Han HB, Han Q, Han B, Han D, Han S, Han X, Han P, Han JY, Han DS, Handsaker R, Hanna-Pladdy B, Hanseeuw B, Hansson B, Hao Y, Hao J, Happ C, Harischandra D, Haritaoglu E, Harris R, Harris B, Hart B, Hartzell J, Harvey D, Hashimoto T, Hasooni H, Hassan M, Hassan M, Hassanzadeh HR, Hassanzadeh O, Hatton S, Hawchar J, Hayashi T, Hayashi N, Hayes J, Hayete B, Haynor D, He L, He Y, He Y, He H, Heegaard N, Hefny M, Heil J, Heindel W, Henderson S, Henf J, Henriquez C, Herholz K, Hermessi H, Hernandez M, Herrera L, Hibar D, Hidane M, Higuchi S, Hind J, Hives F, Hoang M, Hobel Z, Hoffman J, Hofmeister J, Hohman T, Holder D, Holguin J Otd Not PhD, Holmes R, Hong J, Hongliang Z, Hongyu G, Hopkins P, Hor S, Hornbeck R, Horng A, Horton W, Hosny K, Hosseini E, Hosseini H, Hosseini Z, Hosseini Z, Asl EH, Hou B, Hou B, Houghton R, Houghton K, Householder E, Howlett J, Hsiao J, Hsiao IT, Hsu CC, Hu X, Hu L, Hu N, Hu K, Hu T, Hu L, Hu X, Hua F, Huang M, Huang Q, Huang M, Huang C, Huang J, Huang X, Huang Y, Huang SH, Huang S, Huang P, Huang CC, Huang Z, Huang M, Huang Z, Hubrich M, Huestis M, Huey E, Hufton A, Huijbers W, Huisman S, Hung J, Hunsaker N, Hunt F, Huppertz HJ, Huser V, Hussain L, Hutchison RM, Hutton A, Huyck E, Hwang J, Hyun J, Iakovakis D, Ibañez V, Ide K, Igarashi T, Iglesias JE, Muñoz LI, Iidaka T, Ikeuchi T, Ikhena J, Ikuta T, Im HJ, Insausti A, Insel P, Invernizzi A, Iosif AM, Ip N, Irizarry S, Irmak E, Irwin D, Isaza M, Ishii M, Ishii K, Islam J, Israel A, Isufi E, Ito K, Ito M, Izquierdo W, Alphin J, Akhila JA, Jaberzadeh A, Jackowiak E, Jackson E, Jackson C, Jackson J, Jacob S, Jacobsen N, Jacobsen J, Jacquemont T, Jacques N, Jaeger R, Jafari T, Jafari-Khouzani K, Jagadish AK, Jagtap P, Jagust W, Jahr J, Jain S, Jain S, Jaiswal A, Jaiswal A, Jait A, Jakkoju C, Jakobsson A, James O, James O, Jamlai M, Jammeh E, Janardhana L, Jang J, Jang JW, Jang J, Jang H, Janghel RR, Jawahar S, Jean K, Jean-Baptiste S, Jedynak B, Jefferson A, Jennings D, Jennings D, Jeon S, Jeong Y, Jester C, Jethwa K, Jha D, Ji GJ, Ji C, Ji J, Jia B, Jiacheng L, Jiajia G, Jian W, Jiang S, Jiang C, Jianhua G, Jiao Z, Jiao Z, Jiao D, Jimenez Alaniz JR, Gomez CJ, Jiménez-Huete A, Jimura K, Jin Y, Jin Z, Jin Y, Jogia J, Johansson P, John K, Johnsen S, Johnson L, Johnson S, Johnson S, Johnson K, Johnston J, Johnston S, Jomeiri A, Jonas K, Jones R, Jones-Davis D, Jönsson L, Joseph J, Joshi H, Joshi S, Joshi A, Joyce K, Juengling F, Jung Y, Junker V, Junwei D, Jyothi S, Jyotiyana M, Sarthaj K, Kachouane M, Kadian A, Kaewaramsri Y, Kaicheng L, Kaiser M, Kakinami L, Kalra S, Kam HJ, Kamarudin NS, Kaminker J, Kandel B, Kandiah N, Kaneko T, Kang YS, Kang JH, Kang H, Kang J, Kansal A, Kaouache M, Kaplan A, Kottaram AK, Karim F, Karimi-Mostowfi N, Karjoo M, Karlin D, Karp J, Karray C, Kartsonis N, Karu N, Kasa J, Kasiri K, Katako A, Kato R, Katsonis P, Katti H, Kaur P, Kauwe J, Kawaguchi A, Kazemi S, Kazemi Y, Rijan KC, Kechin A, Kelkhoff D, Kelleher T, Kellner-Weldon F, Kennion O, Kerr D, Kesler S, Kesselman C, Kessler D, Keuken M, Keyvanfard F, Khademi A, Khajehnejad M, Khan W, Khan T, Khan H, Khan A, Khan H, Khan S, Khanmohammadi S, Khasanova T, Khazaee A, Khazan L, Kherif F, Khl A, KHlif MS, Khondoker M, Khoo SK, Khosrowabadi R, Khurshid K, Kianfard R, Kida S, Kiddle S, Kikuchi M, Killiany R, Kim J, Kim JH, Kim H, Kim J, Kim YJ, Kim JJ, Kim HR, Kim J, Kim KH, Kim J, Kim J, Kim Y, Kim M, Kim J, Kim B, Kim T, Kim H, Kim S, Kim N, Kim B, Kim C, Kim J, Kim SY, Kim S, Kingery L, Kinnunen K, Kinomes M, Kirchner JH, Caldwell JK, Kirwan B, Kitamura C, Kitty K, Kiviat D, Kiyasova V, Klein R, Klein A, Klein G, Klein J, Klein R, Kleinman A, Kling M, Klinger J, Klinger R, Klink K, Kocaturk M, Koch PJ, Kochova E, Koenig L, Koh N, Köhler JE, Koikkalainen J, Koini M, Kolachalama V, Koncz R, Kong XZ, Kong V, Kong X, Kong D, Kong L, Konukoglu E, Kopeinigg D, Kopera K, Koppers S, Korb M, Korfiatis P, Korolev I, Korolev S, Korostyshevskiy V, Koshiya H, Kost J, Kotari V, Koutra D, Koychev I, Kruthika KR, Krahnke T, Krause M, Kraybill M, Kriebel M, Hari Krishna M, Krohn S, Kruggel F, Kuceyeski A, Kuhl D, Kulshreshtha D, Kumar S, Kumar S, Kumar K, Kumar A, Kumar A, Kumar A, Kumar S, Kumar A, Kumar A, Kumar D, Kumar R, Kumarasinghe J, Kundu S, Kung TH, Kuo LW, Kuo P, Channappa UK, Kuriakose E, Kurian P, Kwan K, Kwasigroch A, Kwon YH, Kyeong S, Fleur C, Wungo S, Labbe T, Lacombe D, Lad M, Lahoti G, Lai YL, Lai C, Lai D, Laird D, Lakatos A, Lam A, Lama R, Lama R, Lambert C, Landau S, Landman B, Landre V, Lane E, Lange C, Langenieux A, Lareau C, Larson K, Latif G, Lauber R, Lawliet ZH, Lawrence E, Lazar A, Le N, Le TK, Le M, Guen YL, Scouiller SL, Leandrou S, Leatherday C, Leavitt M, Ledbetter C, Lee H, Lee W, Lee A, Lee J, Lee D, Lee J, Lee ST, Lee KJ, Lee S, Lee J, Lee C, Lee G, Lee S, Lee E, Lee Y, Lee SG, Lee S, Lee PJ, Lee H, Lee CH, Lee H, Lee MR, Lee I, Lee Q, Lefterov I, Leger C, Lehallier B, Lei B, Lei S, Lei H, Lei H, Leong TY, Leong S, Leoutsakos JM, Lepore N, Lerch O, Leung YS, Leung YY, Leung S, Leung HC, Leung MY, Levakov G, Levine A, Li C, Li M, Li H, Li J, Li X, Li Y, Li J, Li T, Li Y, Li X, Li Y, Li T, Li Y, Li F, Li F, Li S, Li Z, Li X, Li R, Li R, Li YU, Li K, Li Z, Li Z, Li Q, Li W, Li Y, Li J, Li G, Li M, Li Y, Li Y, Li T, Li Z, Li Y, Li M, Li X, Li YJ, Li CS, Li Y, Li XW, Li Y, Li L, Li YJ, Li Y, Li X, Li X, Li XW, Li C, Li C, Li J, Li J, Li T, Li W, Li X, Li N, Li C, Li Y, Liang C, Liang N, Liang J, Liang S, Liang X, Liang X, Liang S, Liang Y, Liberman S, Libon D, Liébana S, Liedes H, Lim WK, Lim YY, Lin Y, Lin K, Lin M, Lin AL, Lin CH, Lin B, Lin L, Lin JM, Lin WM, Lin CT, Lin L, Lin J, Lindberg O, Linesch P, Linn K, Lippert C, Litovka N, Little G, Liu MY, Liu J, Liu CF, Liu Z, Liu E, Liu W, Liu KE, Liu HC, Liu J, Liu R, Liu D, Liu V, Liu W, Liu T, Liu X, Liu Y, Liu L, Liu D, Liu X, Liu M, Liu CS, Liu Y, Liu Y, Liu X, Liu H, Liu CL, Liu S, Liu J, Liu Y, Liu T, Liu T, Liu N, Liu L, Liuyu L, Lizarraga G, 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Abstract

Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups. In this study, 158 subjects (72 NC, 46 sMCI, and 40 cMCI) were selected from the Alzheimer's Disease Neuroimaging Initiative. A sparse-constrained regression model based on the l2-1-norm was introduced to reduce the feature dimensionality and retrieve essential features for the discrimination of the three groups by using a support vector machine (SVM). An optimized strategy of feature addition based on the weight of each feature was adopted for the SVM classifier in order to achieve the best classification performance. The baseline cortical features combined with the longitudinal measurements for 2 years of follow-up data yielded prominent classification results. In particular, the cortical thickness produced a classification with 98.84% accuracy, 97.5% sensitivity, and 100% specificity for the sMCI-cMCI comparison; 92.37% accuracy, 84.78% sensitivity, and 97.22% specificity for the cMCI-NC comparison; and 93.75% accuracy, 92.5% sensitivity, and 94.44% specificity for the sMCI-NC comparison. The best performances obtained by the SVM classifier using the essential features were 5-40% more than those using all of the retained features. The feasibility of the cortical features for the recognition of anatomical patterns was certified; thus, the proposed method has the potential to improve the clinical diagnosis of sub-types of MCI and predict the risk of its conversion to Alzheimer's disease.

KEYWORDS:

classification; conversion; cortical feature; feature reduction; mild cognitive impairment; sparse-constrained regression

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