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Polymers (Basel). 2019 May 7;11(5). pii: E814. doi: 10.3390/polym11050814.

Dual Interactions of Amphiphilic Gelatin Copolymer and Nanocurcumin Improving the Delivery Efficiency of the Nanogels.

Author information

1
Institute of Research and Development, Duy Tan University, Da Nang City 550000, Vietnam. trungnd.iams@gmail.com.
2
Institute of Applied Materials Science, VAST, TL29, ThanhLoc Ward, Dist. 12, Ho Chi Minh City 700000, Vietnam. trungnd.iams@gmail.com.
3
Institute of Applied Materials Science, VAST, TL29, ThanhLoc Ward, Dist. 12, Ho Chi Minh City 700000, Vietnam. thoaidinh106@yahoo.com.
4
Graduate University of Science and Technology, VAST, TL29, Thanh Loc Ward, Dist. 12, Ho Chi Minh City 700000, Vietnam. thoaidinh106@yahoo.com.
5
Institute of Applied Materials Science, VAST, TL29, ThanhLoc Ward, Dist. 12, Ho Chi Minh City 700000, Vietnam. lehadang0804@gmail.com.
6
School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City 700000, Vietnam. lehadang0804@gmail.com.
7
Institute of Research and Development, Duy Tan University, Da Nang City 550000, Vietnam. nguyendangnam@dtu.edu.vn.
8
NTT Hi-Tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, Ward 13, District 4, Ho Chi Minh City 700000, VietNam. blgiang@ntt.edu.vn.
9
Institute of Applied Materials Science, VAST, TL29, ThanhLoc Ward, Dist. 12, Ho Chi Minh City 700000, Vietnam. congtruc2205@gmail.com.
10
Department of Natural Science, Thu Dau Mot University, Thu Dau Mot City 590000, Vietnam. tramntb@tdmu.edu.vn.
11
Institute of Applied Materials Science, VAST, TL29, ThanhLoc Ward, Dist. 12, Ho Chi Minh City 700000, Vietnam. thulv81@yahoo.com.
12
School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City 700000, Vietnam. thulv81@yahoo.com.
13
Institute of Research and Development, Duy Tan University, Da Nang City 550000, Vietnam. tnquyen@iams.vast.vn.
14
Institute of Applied Materials Science, VAST, TL29, ThanhLoc Ward, Dist. 12, Ho Chi Minh City 700000, Vietnam. tnquyen@iams.vast.vn.
15
School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City 700000, Vietnam. tnquyen@iams.vast.vn.

Abstract

Herein, a new process to manufacture multicore micelles nanoparticles reinforced with co-assembly via hydrophobic interaction and electrostatic interaction under the help of ultrasonication was developed. The precise co-assembly between negative/hydrophobic drug and positive charged amphiphilic copolymer based pluronic platform allows the formation of complex micelles structures as the multicore motif with predefined functions. In this study, curcumin was selected as a drug model while positively charged copolymer was based on a pluronic-conjugated gelatin with different hydrophobicity length of Pluronic F87 and Pluronic F127. Under impact of dual hydrophobic and electrostatic interactions, the nCur-encapsulated core-shell micelles formed ranging from 40 nm to 70 nm and 40-100 nm by transmission electron microscopy (TEM) and Dynamic Light Scattering (DLS), respectively. It is found that the structures emerged depended on the relative lengths of the hydrophobic blocks in pluronic. Regarding g2(τ) behavior from DLS measurement, the nanogels showed a high stability in spherical form. Surprisingly, the release profiles showed a sustainable behavior of Cur from this system for drug delivery approaches. In vitro study exhibited that nCur-encapsulated complex micelles increased inhibitory activity against cancer cells growth with IC50 is 4.02 ± 0.11 mg/L (10.92 ± 0.3 µM) which is higher than of free curcumin at 9.40 ± 0.17 mg/L (25.54 ± 0.18 µM). The results obtained can provide the new method to generate the hierarchical assembly of copolymers with incorporated loading with the same property.

KEYWORDS:

delivery; nanocurcumin; nanogels; nanomaterials; pluronic conjugated gelatin (GP) nanogel

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